Hepatology International

, Volume 2, Issue 2, pp 250–257 | Cite as

Metabolic profiles in patients with chronic hepatitis C: a case–control study

  • Ching-Sheng Hsu
  • Chun-Jen Liu
  • Chen-Hua Liu
  • Chi-Ling Chen
  • Ming-Yang Lai
  • Pei-Jer Chen
  • Ding-Shinn Chen
  • Jia-Horng KaoEmail author
Original Article



The clinical implications of metabolic profiles in patients with chronic hepatitis C remain controversial. To study the association of metabolic abnormalities with chronic hepatitis C, we conducted a case–control study with special emphasis on serum lipid pattern, fasting blood glucose, and adiponectin.


We enrolled 500 patients with chronic hepatitis C and 536 sex and age-matched controls. Unadjusted and adjusted associations of demographic and metabolic variables were estimated.


Chronic hepatitis C patients had higher alanine aminotransferase (ALT) and high-density lipoprotein-cholesterol levels, but lower total cholesterol (TC), triglyceride (TG), and low-density lipoprotein-cholesterol levels than controls. Stratifying ALT level according to its upper limit of normal, HCV infection was associated with younger age, female gender, and higher TC levels in chronic hepatitis C patients with normal ALT levels, but with lower TC and lower TG levels in those with abnormal ALT levels. By using multiple linear regression analyses for subjects with available adiponectin data, presence of HCV infection was independently associated with higher serum adiponectin levels.


Metabolic profiles of chronic hepatitis C patients are affected by age, gender, serum adiponectin, and ALT levels. Further longitudinal studies are needed to clarify the complex interplay between HCV infection and metabolic profiles.


Hepatitis C virus ALT Adiponectin Lipid profile Blood glucose 



Hepatitis C virus


Alanine aminotransferase




Total cholesterol


High-density lipoprotein-cholesterol


Low-density lipoprotein-cholesterol


Upper limit of normal





This work was supported by grants from the National Taiwan University Hospital, the Department of Heath, and the National Science Council, Executive Yuan, Taiwan. We thank Dr. Huang SP at the Health Management Center of National Taiwan University Hospital for providing data of non-HCV controls.


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Copyright information

© Asian Pacific Association for the Study of the Liver 2008

Authors and Affiliations

  • Ching-Sheng Hsu
    • 1
    • 2
  • Chun-Jen Liu
    • 3
  • Chen-Hua Liu
    • 3
  • Chi-Ling Chen
    • 4
  • Ming-Yang Lai
    • 3
    • 5
  • Pei-Jer Chen
    • 3
    • 4
    • 5
  • Ding-Shinn Chen
    • 3
    • 4
  • Jia-Horng Kao
    • 3
    • 4
    • 5
    • 6
    Email author
  1. 1.Division of GastroenterologyBuddhist Tzu Chi General HospitalTaipeiTaiwan, ROC
  2. 2.Department of Internal MedicineBuddhist Tzu Chi General HospitalTaipeiTaiwan, ROC
  3. 3.Department of Internal MedicineNational Taiwan University College of Medicine and National Taiwan University HospitalTaipeiTaiwan, ROC
  4. 4.Graduate Institute of Clinical MedicineNational Taiwan University College of Medicine and National Taiwan University HospitalTaipeiTaiwan, ROC
  5. 5.Department of Medical ResearchNational Taiwan University College of Medicine and National Taiwan University HospitalTaipeiTaiwan, ROC
  6. 6.Hepatitis Research CenterNational Taiwan University HospitalTaipeiTaiwan, ROC

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