Metabolic profiles in patients with chronic hepatitis C: a case–control study
- 91 Downloads
The clinical implications of metabolic profiles in patients with chronic hepatitis C remain controversial. To study the association of metabolic abnormalities with chronic hepatitis C, we conducted a case–control study with special emphasis on serum lipid pattern, fasting blood glucose, and adiponectin.
We enrolled 500 patients with chronic hepatitis C and 536 sex and age-matched controls. Unadjusted and adjusted associations of demographic and metabolic variables were estimated.
Chronic hepatitis C patients had higher alanine aminotransferase (ALT) and high-density lipoprotein-cholesterol levels, but lower total cholesterol (TC), triglyceride (TG), and low-density lipoprotein-cholesterol levels than controls. Stratifying ALT level according to its upper limit of normal, HCV infection was associated with younger age, female gender, and higher TC levels in chronic hepatitis C patients with normal ALT levels, but with lower TC and lower TG levels in those with abnormal ALT levels. By using multiple linear regression analyses for subjects with available adiponectin data, presence of HCV infection was independently associated with higher serum adiponectin levels.
Metabolic profiles of chronic hepatitis C patients are affected by age, gender, serum adiponectin, and ALT levels. Further longitudinal studies are needed to clarify the complex interplay between HCV infection and metabolic profiles.
KeywordsHepatitis C virus ALT Adiponectin Lipid profile Blood glucose
Hepatitis C virus
Upper limit of normal
This work was supported by grants from the National Taiwan University Hospital, the Department of Heath, and the National Science Council, Executive Yuan, Taiwan. We thank Dr. Huang SP at the Health Management Center of National Taiwan University Hospital for providing data of non-HCV controls.
- 21.Fumeron F, Aubert R, Siddiq A, et al. Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study. Diabetes. 2004;53:1150–7.PubMedCrossRefGoogle Scholar
- 30.Diagnosis and classification of diabetes mellitus. Diabetes Care. 2006;29 Suppl 1:S43–8.Google Scholar