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Hepatology International

, Volume 2, Issue 2, pp 209–212 | Cite as

Advanced hepatic fibrosis and cirrhosis due to nonalcoholic fatty liver disease in Sri Lankan children: a preliminary report

  • S. RajindrajithEmail author
  • A. S. Dassanayake
  • J. Hewavisenthi
  • H. J. de Silva
NASH (NAFLD), PHT, Hepatic Failure and Others

Abstract

Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases and may progress to advanced hepatic fibrosis and cirrhosis in some patients. Cirrhosis due to NAFLD is considered extremely rare in children in the Asia–Pacific region. We report the characteristics of 5 children with advanced hepatic fibrosis and cirrhosis due to NAFLD. Four of them were obese, and all of them had high alanine transaminase levels and ultrasonographic evidence of fatty liver. None had diabetes mellitus or hyperlipidemia. The calculated HOMA-IR was more than two in all five cases. Liver biopsy showed stage III fibrosis in 2 patients and stage IV fibrosis (cirrhosis) in 3.

Keywords

Nonalcoholic steatohepatits Nonalcoholic fatty liver disease Childhood cirrhosis 

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Copyright information

© Asian Pacific Association for the Study of the Liver 2008

Authors and Affiliations

  • S. Rajindrajith
    • 1
    Email author
  • A. S. Dassanayake
    • 2
  • J. Hewavisenthi
    • 3
  • H. J. de Silva
    • 4
  1. 1.Department of Paediatrics, Faculty of MedicineUniversity of KelaniyaRagamaSri Lanka
  2. 2.Department of Pharmacology, Faculty of MedicineUniversity of KelaniyaRagamaSri Lanka
  3. 3.Department of Pathology, Faculty of MedicineUniversity of KelaniyaRagamaSri Lanka
  4. 4.Department of Medicine, Faculty of MedicineUniversity of KelaniyaRagamaSri Lanka

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