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Hepatology International

, Volume 2, Issue 2, pp 202–208 | Cite as

Comparative redox status in alcoholic liver disease and nonalcoholic fatty liver disease

  • Payal Bhardwaj
  • Kaushal Madan
  • Sandeep Thareja
  • Yogendra Kumar Joshi
  • Anoop SarayaEmail author
NASH (NAFLD), PHT, Hepatic Failure and Others

Abstract

Purpose

Altered redox status has been implicated in pathogenesis of alcoholic liver disease (ALD) as well as in nonalcoholic fatty liver disease (NAFLD). This study was planned to find the relative role of redox status in these two diseases.

Methods

A total of 44 patients with ALD and 32 patients with NAFLD and 25 apparently healthy controls were included in the study. Redox status was estimated by measuring oxidative stress (superoxide dismutase (SOD) and lipid peroxidation products as thiobarbituric acid reactive substances (TBARS)) and antioxidant status (ferric reducing ability of plasma (FRAP) and vitamin C).

Results

TBARS level was raised significantly in both ALD (3.5 (2.3–9.4) vs. 1.8 (0.5–4.1) nmol/ml; P = 0.0001) and NAFLD (5.1 (1–10.2) vs. 1.82 (0.51–4.1) nmol/ml; P = 0.0001) as compared with controls, but was not different between ALD and NAFLD. SOD was significantly higher in ALD as compared to NAFLD (2.4 (1.3–7.8) vs. 0.68 (0.05–19.1) U/ml; P = 0.0001) and controls (1.12 (0.01–3.5) U/ml; P = 0.001). FRAP was lower in ALD as compared with NAFLD (345.4 (56–615.9) vs. 434.1 (197.6–733.3) μmol of Fe+2 liberated; P = 0.001) but similar to that of controls (340.9 (141.5–697.5) μmol of Fe+2 liberated).

Conclusions

ALD patients have a higher degree of redox imbalance as compared with NAFLD patients

Keywords

Alcoholic liver disease Antioxidant status Nonalcoholic fatty liver disease Oxidative stress 

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Copyright information

© Asian Pacific Association for the Study of the Liver 2008

Authors and Affiliations

  • Payal Bhardwaj
    • 1
  • Kaushal Madan
    • 1
  • Sandeep Thareja
    • 1
  • Yogendra Kumar Joshi
    • 1
  • Anoop Saraya
    • 1
    Email author
  1. 1.Department of Gastroenterology and Human Nutrition UnitAll India Institute of Medical SciencesNew DelhiIndia

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