Skip to main content

Advertisement

SpringerLink
Log in

The Effect of Platelet-Rich Plasma on the Healing of Nasal Mucosa After Surgery of the Nose: A Randomized Clinical Trial

  • Original Article
  • Published:
Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Purpose

To investigate the effect of platelet-rich plasma (PRP) on the healing of nasal mucosa after surgery of the nose.

Methods

This prospective, randomized, Comparative Analytic study was conducted on 40 patients. Patients were randomly allocated into two groups: Group A, subjected to PRP, and Group B, who were not subjected to PRP after nasal surgery. The outcome of both Techniques was analyzed and compared.

Results

Significant differences were found in dryness, encrustations, and postoperative healing days in the PRP group. However, no significant differences between the two groups were observed in primary bleeding, secondary bleeding, nasal synechiae, pain, healing time, return to physical activity, and patient satisfaction.

Conclusion

Our study detects the potential hopeful effect of PRP on postoperative wound healing of nasal mucosa, dryness, and nasal crustations. According to these results, the application of PRP post-nasal surgery can be considered an effective method for maintaining post-nasal surgery Mucosa.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Andia I, Abate M (2013) Platelet-rich plasma: underlying biology and clinical correlates. Regen Med 8:645–658

    Article  CAS  PubMed  Google Scholar 

  2. Magalon J, Chateau AL, Bertrand B et al (2016) DEPA classification: a proposal for standardising PRP use and a retrospective application of available devices. BMJ Open Sport Exerc Med 2:e000060

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Kütük SG, Topuz MF, Güvey A, AÇIKGÖZ Ç (2021) The effectiveness of platelet rich plasma therapy in chronic sinusitis patients with odor disorder undergoing endoscopic sinus surgery. Eur Res J

  4. Kuzucu I, Beriat GK, Ezerarslan H et al (2017) Effects of the autologous platelet-rich plasma in nasal pack on postoperative quality of life. J Craniofac Surg 28:e299–e302

    Article  PubMed  Google Scholar 

  5. Kumar MM (2017) Role of platelet-rich plasma on nasal mucociliary clearance after septoplasty–a randomized clinical study. Int J Sci Stud 5:71–75

    Google Scholar 

  6. Chicharro-Alcántara D, Rubio-Zaragoza M, Damiá-Giménez E et al (2018) Platelet rich plasma: new insights for cutaneous wound healing management. J Funct Biomater 9:10

    Article  PubMed  PubMed Central  Google Scholar 

  7. Verma R, Kumar S, Garg P, Verma YK (2023) Platelet-rich plasma: a comparative and economical therapy for wound healing and tissue regeneration. Cell Tissue Bank 24:285–306

    Article  PubMed  Google Scholar 

  8. Zabaglo M, Sharman T (2020) Postoperative wound infection

  9. Sivabalaji K, Ali A, Ashwini BN et al (2021) Management of nasal synechiae with kshara Sutra-A case report. J Ayurveda Integr Med 12:540–543

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Tevis SE, Kennedy GD (2013) Postoperative complications and implications on patient-centered outcomes. J Surg Res 181:106–113

    Article  PubMed  PubMed Central  Google Scholar 

  11. Garimella V, Cellini C (2013) Postoperative pain control. Clin Colon Rectal Surg 26:191–196

    Article  PubMed  PubMed Central  Google Scholar 

  12. Apfelbaum JL, Chen C, Mehta SS, Gan TJ (2003) Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg 97:534–540

    Article  PubMed  Google Scholar 

  13. Geneen LJ, Moore RA, Clarke C et al (2017) Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews. Cochrane Database Syst Rev

  14. Salaheldin AH, Hussein A (2012) Effect of platelet-rich plasma on nasal mucociliary clearance after submucous diathermy of inferior turbinate. Egypt J Ear Nose Throat Allied Sci 13:71–75

    Article  Google Scholar 

  15. Saad Setta H, Elshahat A, Elsherbiny K, Massoud K, Safe I (2011) Platelet-rich plasma versus platelet-poor plasma in the management of chronic diabetic foot ulcers: a comparative study. Int Wound J 8(3):307–312. https://doi.org/10.1111/j.1742-481X.2011.00797.xEpub 2011 Apr 7. PMID: 21470370; PMCID: PMC7950579

    Article  PubMed  PubMed Central  Google Scholar 

  16. Ogundipe OK, Ugboko VI, Owotade FJ (2011) Can autologous platelet-rich plasma gel enhance healing after surgical extraction of mandibular third molars? J Oral Maxillofac Surg 69:2305–2310

    Article  PubMed  Google Scholar 

  17. Boztug CY, Karaagac Akyol T, Benlice C et al (2021) Platelet-rich plasma treatment improves postoperative recovery in patients with pilonidal sinus disease: a randomized controlled clinical trial. BMC Surg 21:1–9

    Article  Google Scholar 

  18. Ford RD, Schmitt WP, Lineberry K, Luce P (2015) A retrospective comparison of the management of recalcitrant lateral elbow tendinosis: platelet-rich plasma injections versus surgery. Hand 10:285–291

    Article  PubMed  Google Scholar 

  19. Carter MJ, Fylling CP, Parnell LK (2011) Use of platelet rich plasma gel on wound healing: a systematic review and meta-analysis. Eplasty 11

  20. Xu P, Wu Y, Zhou L et al (2020) Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization. Burns Trauma 8:tkaa028

    Article  PubMed  PubMed Central  Google Scholar 

  21. Subramanian P, Ramasamy S, Ng KH et al (2016) Pain experience and satisfaction with postoperative pain control among surgical patients. Int J Nurs Pract 22:232–238

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

None.

Funding

None.

Author information

Authors and Affiliations

  1. Professor of Otorhinolaryngology, Faculty of Medicine, Al-Azhar University, Assiut, MD, Egypt

    Yousry Othman Abd Elrahman

  2. Lecturer of Otorhinolaryngology, Faculty of Medicine, Al-Azhar University, Assiut, MD, Egypt

    Hussein Magdy Abdelkader

  3. Lecturer of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Assiut, MD, Egypt

    Mohamed Ahmed Bashir Ahmed

  4. Resident doctor at Otorhinolaryngology Department, Faculty of Medicine, Al-Azhar University, Assiut, MBChB, Egypt

    Alaa Abd El Wahab Eldarawy & Ahmed Selim

  5. Medical Research Group of Egypt (MRGE), Negida Academy, Arlington, MA, USA

    Ahmed Selim

Authors
  1. Yousry Othman Abd Elrahman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hussein Magdy Abdelkader
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mohamed Ahmed Bashir Ahmed
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alaa Abd El Wahab Eldarawy
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ahmed Selim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Alaa Abd El Wahab Eldarawy.

Ethics declarations

Conflict of interest

None.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Elrahman, Y.O.A., Abdelkader, H.M., Ahmed, M.A.B. et al. The Effect of Platelet-Rich Plasma on the Healing of Nasal Mucosa After Surgery of the Nose: A Randomized Clinical Trial. Indian J Otolaryngol Head Neck Surg (2024). https://doi.org/10.1007/s12070-024-04683-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12070-024-04683-y

Keywords

Search

Navigation