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Pathologically Negative Excision for Biopsy-Proven Early Glottic Carcinoma

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Abstract

In certain instances, patients who underwent endoscopic laser excision (ELE) for biopsy-proven early glottic carcinoma do not show any evidence of carcinomatous cells on histopathologic analysis. Our study aims to determine the incidence of this phenomenon. A retrospective analysis of patients with biopsy-proven early glottic squamous cell carcinoma who underwent ELE was conducted. 121 patients with a mean age of 68.2 ± 10.7 were included in this study. Initial biopsy showed carcinoma in situ in 38 patients, (31.4%), T1a in 41 patients (33.9%), and T1b in 42 patients (34.7%). Following ELE, a pathologically negative excision was seen in 26 patients (21.5%). Disease recurrence occurred in 3 patients who had a pathologically negative excision (11.5%). Following repeat ELE, all patients remained disease free. A significant number of early glottic carcinoma present with small volume disease which may be eradicated with diagnostic biopsy alone.

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No funding received for this study.

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Authors and Affiliations

  1. Department of Otolaryngology Head and Neck Surgery, Westmead Hospital, Sydney, Australia

    Richard Tjahjono & Faruque Riffat

  2. Department of Head and Neck Surgery, Chris O’Brien Lifehouse Joint Head of ENT – HNS, University of Sydney, 119-143 Missenden Rd, Camperdown, Sydney, NSW, 2050, Australia

    Navid Ahmadi, Faruque Riffat & Carsten E. Palme

  3. Department of Otolaryngology Head and Neck Surgery, Royal Prince Alfred Hospital, Sydney, Australia

    Navid Ahmadi

  4. Department of Head and Neck Surgical Oncology, Cytecare Cancer Hospitals, Bengaluru, Karnataka, India

    Akshay Kudpaje

  5. Faculty of Medicine, University of Sydney, Sydney, Australia

    Richard Tjahjono, Faruque Riffat & Carsten E. Palme

  6. Faculty of Medicine, University of New South Wales, Sydney, Australia

    Navid Ahmadi

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  1. Richard Tjahjono
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  2. Navid Ahmadi
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  5. Carsten E. Palme
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Correspondence to Carsten E. Palme.

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Tjahjono, R., Ahmadi, N., Riffat, F. et al. Pathologically Negative Excision for Biopsy-Proven Early Glottic Carcinoma. Indian J Otolaryngol Head Neck Surg 75, 278–281 (2023). https://doi.org/10.1007/s12070-022-03232-9

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  • DOI: https://doi.org/10.1007/s12070-022-03232-9

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