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The Value of Ultrasound-guided Core Needle Biopsy in Differentiating Benign from Malignant Salivary Gland Lesions

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

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Abstract

Purpose

In recent years, core needle biopsy (CNB) technique has received much attention, being used as alternative method of tissue sampling for surgical biopsy of salivary gland tumors (SGTs). The present study aimed to evaluate the value of CNB in differentiating benign from malignant SGTs.

Materials and methods

Patients with suspected benign or malignant SGTs in imaging were enrolled in this study. All core needle biopsies were performed under ultrasound guidance, i.e. ultrasound-guided Core Needle Biopsy (USCNB). Histological examination of the specimen after surgical excision was regarded as gold standard test and set as reference standard to assess USCNB accuracy for discriminating between ultrasound-visible benign and malignant SGTs.

Results

Based on USCNB results, from 36 participants (14 women and 22 men) with SGTs, 44.4% of detected tumors were benign and 55.5% were malignant. Twenty-two patients underwent surgery and postoperative specimen histological examination showed that 59% of excised lesions were benign and 41% were malignant. USCNB and surgical biopsy (SB) findings were completely compatible for 21 patients. Sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of USCNB were 100% in differentiating malignant from benign lesions.

Conclusion

USCNB is a valuable and accurate method of diagnosis with high sensitivity and specificity in distinguishing benign from malignant ultrasound-visible SGTs.

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Data Availability

The datasets generated during the current study are available from the corresponding author on reasonable request.

References

  1. Singh Nanda KD, Mehta A, Nanda J (2012 Jan) Fine-needle aspiration cytology: a reliable tool in the diagnosis of salivary gland lesions. J oral Pathol Med 41(1):106–112

  2. Schmidt RL, Hall BJ, Wilson AR, Layfield LJ (2011) A systematic review and meta-analysis of the diagnostic accuracy of fine-needle aspiration cytology for parotid gland lesions. Am J Clin Pathol 136:45–59

    Article  PubMed  Google Scholar 

  3. Kim BY, Hyeon J, Ryu G et al (2013) Diagnostic accuracy of fine needle aspiration cytology for high-grade salivary gland tumors. Ann Surg Oncol 20:2380–2387

    Article  PubMed  Google Scholar 

  4. Tryggvason G, Gailey MP, Hulstein SL et al (2013) Accuracy of fine-needle aspiration and imaging in the preoperative workup of salivary gland mass lesions treated surgically. Laryngoscope 123:158–163

    Article  PubMed  Google Scholar 

  5. Nguansangiam S, Jesdapatarakul S, Dhanarak N, Sosrisakorn K (2012) Accuracy of fine needle aspiration cytology of salivary gland lesions: routine diagnostic experience in Bangkok, Thailand. Asian Pac J Cancer Prev 13:1583–1588

    Article  PubMed  Google Scholar 

  6. Huang YT, Jung SM, Ko SF et al (2012) Diagnostic efficacy of ultrasonography-guided fine needle aspiration biopsy in evaluating salivary gland malignancy. Chang Gung Med J 35:62–69

    PubMed  Google Scholar 

  7. Kechagias N, Ntomouchtsis A, Valeri R et al (2012) Fine-needle aspiration cytology of salivary gland tumours: a 10-year retrospective analysis. Oral Maxillofac Surg 16:35–40

    Article  PubMed  Google Scholar 

  8. Piccioni LO, Fabiano B, Gemma M, Sarandria D, Bussi M (2011) Fine-needle aspiration cytology in the diagnosis of parotid lesions. Acta Otorhinolaryngol Ital 31:1–4

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Cho HW, Kim J, Choi J et al (2011) Sonographically guided fine-needle aspiration biopsy of major salivary gland masses: a review of 245 cases. AJR Am J Roentgenol 196:1160–1163

    Article  PubMed  Google Scholar 

  10. Schmidt RL, Hall BJ, Layfield LJ et al (2011) A systematic review and meta-analysis of the diagnostic accuracy of ultrasound-guided core needle biopsy for salivary gland lesions. Am J Clin Pathol 136:516–526

    Article  PubMed  Google Scholar 

  11. Novoa E, Gurtler N, Arnoux A, Kraft M (2012) Role of ultrasound-guided core-needle biopsy in the assessment of head and neck lesions: a meta-analysis and systematic review of the literature. Head Neck 34:1497–1503

    Article  PubMed  Google Scholar 

  12. Pfeiffer J, Ridder GJ (2012) Diagnostic value of ultrasound-guided core needle biopsy in patients with salivary gland masses. Int J Oral Maxillofac Surg 41:437–443

    Article  CAS  PubMed  Google Scholar 

  13. Huang YC, Wu CT, Lin G, Chuang WY, Yeow KM, Wan YL (2012) Comparison of ultrasonographically guided fine-needle aspiration and core needle biopsy in the diagnosis of parotid masses. J Clin Ultrasound 40:189–194

    Article  PubMed  Google Scholar 

  14. Vander Poorten V, Bradley PJ, Takes RP, Rinaldo A, Woolgar JA, Ferlito A (2012) Diagnosis and management of parotid carcinoma with a special focus on recent advances in molecular biology. Head Neck 34(3):429–440

    Article  PubMed  Google Scholar 

  15. Song IH, Song JS, Sung CO, Roh JL, Choi SH, Nam SY, Kim SY, Lee JH, Baek JH, Cho KJ (2015 Mar) Accuracy of core needle biopsy versus fine needle aspiration cytology for diagnosing salivary gland tumors. J Pathol translational Med 49(2):136

  16. Huang YC, Wu CT, Lin G, Chuang WY, Yeow KM, Wan YL (2012 May) Comparison of ultrasonographically guided fine-needle aspiration and core needle biopsy in the diagnosis of parotid masses. J Clin Ultrasound 40(4):189–194

  17. Eom HJ, Lee JH, Ko MS, Choi YJ, Yoon RG, Cho KJ, Nam SY, Baek JH (2015 Jun) Comparison of fine-needle aspiration and core needle biopsy under ultrasonographic guidance for detecting malignancy and for the tissue-specific diagnosis of salivary gland tumors. Am J Neuroradiol 1(6):1188–1193

  18. Witt BL, Schmidt RL (2014 Mar) Ultrasound-guided core needle biopsy of salivary gland lesions: A systematic review and meta‐analysis. Laryngoscope 124(3):695–700

  19. Kim HJ, Kim JS (2018 Jan) Ultrasound-guided core needle biopsy in salivary glands: A meta‐analysis. Laryngoscope 128(1):118–125

  20. Wan YL, Chan SC, Chen YL, Cheung YC, Lui KW, Wong HF, Hsueh C, See LC Ultrasonography-guided core-needle biopsy of parotid gland masses.American journal of neuroradiology. 2004 Oct1; 25(9):1608–12

  21. Li G, Zhang Z, Zhang J, Jin T, Liang H, Gong L, Cui G, Yang H, He S, Zhang Y, Gao G (2014 Dec) Occipital anaplastic oligodendroglioma with multiple organ metastases after a short clinical course: a case report and literature review. Diagn Pathol 9(1):17

  22. Dhouib H, Hammami B, Sellami M, Mnif L, Boudawara T, Ghorbel A (2010) Xanthogranulome parotidien de l’adulte [Xanthogranuloma of the parotid gland in adults]. Rev Stomatol Chir Maxillofac 111(5–6):337–339

    Article  CAS  PubMed  Google Scholar 

  23. Li G, Zhang Z, Zhang J, Jin T, Liang H, Gong L, Cui G, Yang H, He S, Zhang Y, Gao G (2014 Dec) Occipital anaplastic oligodendroglioma with multiple organ metastases after a short clinical course: a case report and literature review. Diagn Pathol 9(1):1–6

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Acknowledgements

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Funding

There was no financial support from any institution.

Author information

Authors and Affiliations

  1. Department of Radiology, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Mohammad Ali Kazemi, Farzaneh Amini & Hashem Sharifian

  2. Department of radiology, Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Medical Imaging Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran

    Mohammad Ali Kazemi, Hashem Sharifian & Behnaz Moradi

  3. Faculty of medicine, Islamic Azad University Tehran Medical Sciences, Tehran, Iran

    Bita Kargar

  4. Department of Pathology, Amiralam Hospital Complexes, Tehran University of Medical Sciences, Tehran, Iran

    Maryam Lotfi

  5. Otorhinolaryngology research center, Tehran University of Medical Sciences, Tehran, Iran

    Keyvan Aghazadeh

  6. Department of Radiology, Women’ Yas Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Behnaz Moradi

  7. Department of Radiology, Faculty of Medicine, Kashan University of Medical Sciences, Shahid Beheshti Hospital, Qotb Ravandi Blvd, 8715981151, Kashan, Iran

    Javid Azadbakht

Authors
  1. Mohammad Ali Kazemi
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  2. Farzaneh Amini
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  3. Bita Kargar
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  4. Maryam Lotfi
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  5. Keyvan Aghazadeh
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  6. Hashem Sharifian
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  7. Behnaz Moradi
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  8. Javid Azadbakht
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Mohammad Ali Kazemi, Farzane Amini, Behnaz Moradi, Bita Kargar, Maryam Lotfi, Keyvan Aghazadeh, and Hashem Sharifian. The first draft of the manuscript was written by Mohammad Ali Kazemi, Behnaz Moradi, and Javid Azadbakht. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Javid Azadbakht.

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Competing Interests

The authors declare no conflict of interest.

Ethical Approval

This article does not contain any studies with animals performed by any of the authors. All procedures performed in this study involving human participant was in accordance with with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Ethics committee of Tehran University of Medical Sciences approved this study.

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Kazemi, M.A., Amini, F., Kargar, B. et al. The Value of Ultrasound-guided Core Needle Biopsy in Differentiating Benign from Malignant Salivary Gland Lesions. Indian J Otolaryngol Head Neck Surg 75, 266–270 (2023). https://doi.org/10.1007/s12070-022-03148-4

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  • DOI: https://doi.org/10.1007/s12070-022-03148-4

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