Skip to main content
Log in

A Rare Case of Nodular Lymphocyte Predominance Hodgkin’s Lymphoma of the Parotid Gland: Diagnostic Pitfall in Fine Needle Aspiration Cytology

  • Clinical Report
  • Published:
Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Primary malignant lymphoma of the salivary glands is a very rare entity, and primary parotid Hodgkin’s Lymphoma (HL) is even rarer. It is rare in the initial evaluation to suspect a parotid tumor. Thus, it is important to keep lymphomatous involvement in mind when facing parotid masses in differential diagnosis. This study presented a case of a 56-year-old male with a 5-month history of left cheek enlargement. Fine Needle Aspiration (FNA) biopsy was performed with no suspicion for lymphoma. Parotidectomy was also done and nodular lymphocyte predominance HL within the parotid gland was confirmed by immunohistochemical study. The Nodular Lymphocyte Predominance Hodgkin’s Lymphoma has been defined as a specific histopathological subtype of HL. The initial diagnostic approach is usually carried out through FNA, obtaining high sensitivity and specificity, which allows establishing an adjusted for co-correct diagnosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Von Stritzky M, Wereldsma JC, Pegels JG (1998) Parotid mass as first symptom of a maligmant lymphoma. J Surg Oncol 67:25–27

    Article  Google Scholar 

  2. Ihrler S, Adam P, Guntinas-Lichius O et al (2009) Pattern recognition in the differential diagnosis of salivary lymphoepithelial lesions. Pathologe 31:432–441

    Article  Google Scholar 

  3. Swerdlow SH, Campo E, Harris NL et al (eds) (2008) WHO classification of tumours of haematopoietic and lymphoid tissues, 4th edn. International Agency of Research in Cancer, Lyon, p 439

    Google Scholar 

  4. Azarpira N, Ashraf MJ, Khademi B (2007) Primary Hodgkin’s lymphoma of the parotid gland: a case report. MJIRI 20(4):212–214

    Google Scholar 

  5. Agaimy A et al (2015) Intraparotid classical and nodular Lymphocyte predominant Hodgkin lymphoma, pattern analysis with emphasis on associated Lymphadenoma-like proliferations. Am J Surg Pathol 39(9):1206–1212

    Article  Google Scholar 

  6. MezeiI T et al (2018) The value of fine needle aspiration cytology in the clinical management of rare salivary gland tumors. J Appl Oral Sci 26:e20170267

    Article  Google Scholar 

  7. Biswajit D (2016) A rare cytological diagnosis of primary non-Hodgkin lymphoma of the parotid gland. J Cytol 33(2):108

    Article  Google Scholar 

  8. Faquin WC, Rossi ED (eds) (2018) The Milan system for reporting salivary gland cytopathology. Springer Science+Business Media, New York, NY

    Google Scholar 

  9. Subhawong AP et al (2012) Nodular lymphocyte-predominant Hodgkin lymphoma, Cytopathologic correlates on fine-needle aspiration. Cancer Cytopathol 120:254–260

    Article  Google Scholar 

Download references

Acknowledgements

The authors would like to thank Ms. A. Keivanshekouh at the Research Improvement Center of Shiraz University of Medical Sciences for improving the use of English in the manuscript.

Author information

Authors and Affiliations

Authors

Contributions

MJA performed the histological examination of the parotid gland. AM performed and analyzed IHC study. NT analyzed and interpreted the patient data. BKH performed surgery and followed up the patient.

Corresponding author

Correspondence to Negar Taheri.

Ethics declarations

Conflict of interests

The authors declare that they have no competing interests.

Consent to Participate

There was no need for the patient’s consent based on our university policy, because this study did not contain any identifiable information related to the patient.

Ethics Approval

There was no need for the patient’s consent based on our university policy, because this study did not contain any identifiable information related to the patient.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ashraf, M.J., Monabati, A., Taheri, N. et al. A Rare Case of Nodular Lymphocyte Predominance Hodgkin’s Lymphoma of the Parotid Gland: Diagnostic Pitfall in Fine Needle Aspiration Cytology. Indian J Otolaryngol Head Neck Surg 74 (Suppl 3), 6129–6133 (2022). https://doi.org/10.1007/s12070-021-02776-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12070-021-02776-6

Keywords

Navigation