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Ropivacaine: A Novel Local Anaesthetic Drug to Use in Otorhinolaryngology Practice

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Abstract

Ropivacaine is a long-acting amide local anaesthetic agent which has a significant vasoconstrictive property, long duration of action, least central nervous system and cardiac complications due to the pure (S)-enantiomer property by reversible inhibition of sodium ion influx in nerve fibres. By using additives the duration of analgesia may be prolonged. Ropivacaine has been used routinely in our otorhinolaryngology procedures since 2010 (10 years). The present article details the clinical applications of ropivacaine and its current place as a local anaesthetic in otorhinolaryngology practice.

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References

  1. Hansen TG (2004) Ropivacaine: a pharmacological review. Expert Rev Neurother 4(5):781–791. https://doi.org/10.1586/14737175.4.5.781

    Article  CAS  PubMed  Google Scholar 

  2. McClellan KJ, Faulds D (2000) Ropivacaine. Drugs 60:1065–1093. https://doi.org/10.2165/00003495-200060050-00007

    Article  CAS  PubMed  Google Scholar 

  3. Kindler CH, Paul M, Zou H et al (2003) Amide local anesthetics potently inhibit the human tandem pore domain background K+ channel TASK-2 (KCNK5). J PharmacolExpTher 306(1):84–92. https://doi.org/10.1124/jpet.103.049809

    Article  CAS  Google Scholar 

  4. Graf BM, Abraham I, Eberbach N, Kunst G, Stowe DF, Martin E (2002) Differences in cardiotoxicity of bupivacaine and ropivacaine are the result of physicochemical and stereoselective properties. Anesthesiology 96(6):1427–1434. https://doi.org/10.1097/00000542-200206000-00023

    Article  CAS  PubMed  Google Scholar 

  5. Dony P, Dewinde V, Vanderick B et al (2000) The comparative toxicity of ropivacaine and bupivacaine at equipotent doses in rats. AnesthAnalg 91(6):1489–1492. https://doi.org/10.1097/00000539-200012000-00036

    Article  CAS  Google Scholar 

  6. Knudsen K, Beckman Suurküla M, Blomberg S, Sjövall J, Edvardsson N (1997) Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers. Br J Anaesth 78(5):507–514. https://doi.org/10.1093/bja/78.5.507

    Article  CAS  PubMed  Google Scholar 

  7. Porter J, Crowe B, Cahill M, Shorten G (2001) The effects of ropivacaine hydrochloride on platelet function: an assessment using the platelet function analyser (PFA-100). Anaesthesia 56(1):15–18. https://doi.org/10.1046/j.1365-2044.2001.01760.x

    Article  CAS  PubMed  Google Scholar 

  8. Bátai I, Kerényi M, Falvai J, Szabó G (2002) Bacterial growth in ropivacaine hydrochloride. AnesthAnalg 94(3):729–731. https://doi.org/10.1097/00000539-200203000-00046

    Article  Google Scholar 

  9. Kampe S, Poetter C, Buzello S, Wenchel HM, Paul M, Kiencke P et al (2003) Ropivacaine 01% with sufentanil 1 microg/mL inhibits in vitro growth of Pseudomonas aeruginosa and does not promote multiplication of Staphylococcus aureus. AnesthAnalg 97:409–411

    CAS  Google Scholar 

  10. Simpson D, Curran MP, Oldfield V, Keating GM (2005) Ropivacaine: a review of its use in regional anaesthesia and acute pain management. Drugs 65(18):2675–2717. https://doi.org/10.2165/00003495-200565180-00013

    Article  CAS  PubMed  Google Scholar 

  11. Burm AG, Stienstra R, Brouwer RP, Emanuelsson BM, van Kleef JW (2000) Epidural infusion of ropivacaine for postoperative analgesia after major orthopedic surgery: pharmacokinetic evaluation. Anesthesiology 93(2):395–403. https://doi.org/10.1097/00000542-200008000-00017

    Article  CAS  PubMed  Google Scholar 

  12. Ekström G, Gunnarsson UB (1996) Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P4501A and 3A in human liver microsomes. Drug MetabDispos 24(9):955–961

    Google Scholar 

  13. Lee A, Fagan D, Lamont M, Tucker GT, Halldin M, Scott DB (1989) Disposition kinetics of ropivacaine in humans. AnesthAnalg 69(6):736–738

    CAS  Google Scholar 

  14. Berde CB, Strichartz GR (2010) Local anesthetics. In: Miller RD, Eriksson LI, Fleisher LA, Wiener-Kronish JP, Young WL (eds) Miller’s anesthesia, 7th edn. Churchill-Livingstone, Philadelphia, PA, pp 917–918

    Google Scholar 

  15. Scott DB, Lee A, Fagan D, Bowler GM, Bloomfield P, Lundh R (1989) Acute toxicity of ropivacaine compared with that of bupivacaine. AnesthAnalg 69(5):563–569

    CAS  Google Scholar 

  16. Gunter JB (2002) Benefit and risks of local anesthetics in infants and children. Paediatr Drugs 4(10):649–672. https://doi.org/10.2165/00128072-200204100-00003

    Article  PubMed  Google Scholar 

  17. Karaman E, Gungor G, Alimoglu Y et al (2011) The effect of lidocaine, bupivacaine and ropivacaine in nasal packs on pain and hemorrhage after septoplasty. Eur Arch Otorhinolaryngol 268(5):685–689. https://doi.org/10.1007/s00405-010-1432-7

    Article  PubMed  Google Scholar 

  18. Gencer ZK, Ozkiriş M, Gencer M, Saydam L (2013) Comparison of ropivacaine, bupivacaine, prilocaine, and lidocaine in the management of pain and hemorrhage during nasal pack removal. Am J Rhinol Allergy 27(5):423–425. https://doi.org/10.2500/ajra.2013.27.3945

    Article  PubMed  Google Scholar 

  19. Shaffer AD, Jabbour N, Visoiu M, Yang CI, Yellon RF (2016) Paravertebral nerve block for donor site pain in stage I microtia reconstruction: a pilot study. Otolaryngol Head Neck Surg 154(5):898–901. https://doi.org/10.1177/0194599816629395

    Article  PubMed  Google Scholar 

  20. Byram SC, Bialek SE, Husak VA et al (2020) Distinct neurotoxic effects of select local anesthetics on facial nerve injury and recovery. RestorNeurolNeurosci 38(2):173–183. https://doi.org/10.3233/RNN-190987

    Article  CAS  Google Scholar 

  21. Ozkiriş M, Kapusuz Z, Saydam L (2012) Comparison of ropivacaine, bupivacaine and lidocaine in the management of post-tonsillectomy pain. Int J PediatrOtorhinolaryngol 76(12):1831–1834. https://doi.org/10.1016/j.ijporl.2012.09.011

    Article  Google Scholar 

  22. Giannoni C, White S, Enneking FK, Morey T (2001) Ropivacaine with or without clonidine improves pediatric tonsillectomy pain. Arch Otolaryngol Head Neck Surg 127(10):1265–1270. https://doi.org/10.1001/archotol.127.10.1265

    Article  CAS  PubMed  Google Scholar 

  23. Ponstein NA, Kim TW, Hsia J, Goode R, Borges P, Mariano ER (2013) Continuous lesser palatine nerve block for postoperative analgesia after uvulopalatopharyngoplasty. Clin J Pain 29(12):e35–e38. https://doi.org/10.1097/AJP.0b013e3182971887

    Article  PubMed  Google Scholar 

  24. Catterall WA, Mackie K (2018) Local anesthetics. In: Brunton LL, Hilal-Dandan R, Knollman BC (eds) Goodman and Gilman’s the pharmacological basis of therapeutics, 13th edn. McGraw-Hill, New York, pp 405–420

    Google Scholar 

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Acknowledgements

We would like to thank all patients who had undergone surgical procedure with the use of local anesthetic ropivacaine, this encouraged us to share and submit the manuscript for publication in a scientific research journal.

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Authors and Affiliations

  1. Ahilasamy ENT Centre, Chennai, Tamil Nadu, 600 042, India

    Nagalingeswaran Ahilasamy

  2. Department of ENT and Head-Neck Surgery, Rajarajeswari Medical College and Hospital, Bengaluru, Karnataka, 560074, India

    Rajendran Dinesh Kumar, K. R. Vaibhavi & Vishakha Modak

  3. Prashanth Super Specialty Hospital, Velachery, Chennai, 600042, India

    Hem Anand Nayagam & Omprakash Shanmuganandam

Authors
  1. Nagalingeswaran Ahilasamy
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  2. Rajendran Dinesh Kumar
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  3. Hem Anand Nayagam
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  4. Omprakash Shanmuganandam
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  5. K. R. Vaibhavi
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  6. Vishakha Modak
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Contributions

AN: Chief Operating surgeon, Substantial contributions to the conception of the work; acquisition, analysis and interpretation of data for the work. A continuous source of inspiration, encouragement, motivation for submission for publication. RDK: Drafting the work or revising it critically for important intellectual content. HAN: Review of literature, Drafting the article and revising it critically for important intellectual content. OS: Review of literature and Manuscript. KRV: Review of the Literature and Manuscript. VM: Review of Literature

Corresponding author

Correspondence to Rajendran Dinesh Kumar.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from individual participant included in the study.

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Ahilasamy, N., Dinesh Kumar, R., Nayagam, H.A. et al. Ropivacaine: A Novel Local Anaesthetic Drug to Use in Otorhinolaryngology Practice. Indian J Otolaryngol Head Neck Surg 73, 267–270 (2021). https://doi.org/10.1007/s12070-020-02309-7

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  • DOI: https://doi.org/10.1007/s12070-020-02309-7

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