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Pattern of Nodal Metastasis in Relation to Size of the Primary Tumour in Well-Differentiated Thyroid Carcinoma

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

This study was conducted to see the pattern of neck node metastasis in relation to the size of primary tumour in Well-differentiated thyroid cancer. A prospective study on 50 patients was carried out in the Department of Head and Neck Surgery, Dr B. Borooah Cancer Institute from 1st August, 2018 to 31st July, 2019. All new cases who had not previously received treatment were included which were histopathogically proven. Residual and recurrent cases were not taken into account. Most common age-group affected was 21–30 years (24%). It was more common in females (84%). Papillary thyroid cancer has been found to be the most common histological type of WDTC (88%), out of which the classical variant of PTC constitute 72%. 46% of them had tumour size > 4 cm 88% cases had cervical neck node metastases, out of which 72% were unilateral and 16% were bilateral. The commonest level involved was level VI. There is a definite correlation (clinical and histological) between increased involvement of positivity of lymph node in relation to size of the primary tumour in well-differentiated thyroid carcinoma.

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References

  1. Sipos JA, Mazzaferri EL (2010) Thyroid cancer epidemiology and pognostic variables. J Clin Oncol 22(6):395–404

    Article  CAS  Google Scholar 

  2. Tuttle RM, Leboeuf R (2008) Follow up approaches in thyroid cancer: a risk adapted paradigm. J Clin Endocrinol Metab 37(2):419–435

    Article  Google Scholar 

  3. Sippel RS, Chen H (2009) Controversies in the surgical management of newly diagnosed and recurrent/residual thyroid cancer. Thyroid 19(12):1373–1380

    Article  PubMed  Google Scholar 

  4. McHenry CR, Phitayakorn R (2010) Difficult problems in thyroid cancer surgery. Minerva Chir 65(1):83–93

    CAS  PubMed  Google Scholar 

  5. Sadowski BM, Snyder SK, Lairmore TC (2009) Routine bilateral central lymph node clearance for papillary thyroid cancer. Surgery 146(4):696–703

    Article  PubMed  Google Scholar 

  6. Senyurek YG, Tunca F, Boztepe H, Alagöl F, Terzioglu T, Tezelman S (2009) The long term outcome of papillary thyroid carcinoma patients without primary central lymph node dissection: expected improvement of routine dissection. Surgery 146(6):1188–1195

    Article  Google Scholar 

  7. Qubain SW, Nakano S, Baba M, Takao S, Aikou T (2002) Distribution of lymph node micrometastasis in pN0 well-differentiated thyroid carcinoma. Surgery 131(3):249–256

    Article  PubMed  Google Scholar 

  8. Leboulleux S, Rubino C, Baudin E et al (2005) Prognostic factors for persistent or recurrent disease of papillary thyroid carcinoma with neck lymph node metastases and/or tumor extension beyond the thyroid capsule at initial diagnosis. J Clin Endocrinol Metab 90(10):5723–5729

    Article  CAS  PubMed  Google Scholar 

  9. Lundgren CI, Hall P, Dickman PW, Zedenius J (2006) Clinically significant prognostic factors for differentiated thyroid carcinoma: a populationed-based, nested case-control study. Cancer 106(3):524–531

    Article  PubMed  Google Scholar 

  10. Mazzaferri EL, Jhiang SM (1994) Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med 97:418–428

    Article  CAS  PubMed  Google Scholar 

  11. Shaha AR (2004) Prognostic factors in papillary thyroid carcinoma and implications of large nodal metastasis. Surgery 135:237–239

    Article  PubMed  Google Scholar 

  12. Ortega J, Sala C, Flor B, Lledo S (2004) Efficacy and cost–effectiveness of the ultracision harmonic scalpel in thyroid surgery: an analysis of 200 cases in a randomized trial. J Laparoendosc Adv Surg Tech A 14:9–12

    Article  PubMed  Google Scholar 

  13. Davies L, Welch HG (2006) Increasing incidence of thyroid cancer in the united states, 1973–2002. JAMA 295:2164–2167

    Article  CAS  PubMed  Google Scholar 

  14. Crile GJ (1956) The pattern of metastasis of carcinoma of the thyroid. Ann Surg 143(5):580–587

    Article  PubMed  PubMed Central  Google Scholar 

  15. Kupferman ME, Patterson M, Mandel SJ, LiVolsi V, Weber RS (2004) Patterns of lateral neck metastasis in papillary thyroid carcinoma. Arch Otolaryngol Head Neck Surg 130:857–860

    Article  PubMed  Google Scholar 

  16. Pingpank JF Jr, Sasson AR, Hanlon AL, Friedman CD, Ridge JA (2002) Tumor above the spinal accessory nerve in papillary thyroid cancer that involves lateral neck nodes: a common occurrence. Arch Otolaryngol Head Neck Surg 128:1275–1278

    Article  PubMed  Google Scholar 

  17. Stell & Maran’s (2011) Textbook of head and neck surgery and oncology, CRC Press, Boca Raton

  18. Goropoulos A, Karamoshos K, Christodoulou A, et al. (2004) Value of the cervical compartments in the surgical treatment of papillary thyroid carcinoma.World J. Surg. 28(12):1275–1281.

  19. Gimm O, Rath FW, Dralle H (1998) Pattern of lymph node metastases in papillary thyroid carcinoma. Br J Surg 85(2):252–254

    Article  CAS  PubMed  Google Scholar 

  20. Machens A, Hinze R, Thomusch O, Dralle H (2002) Pattern of nodal metastasis for primary and reoperative thyroid cancer. World J Surg 26(1):22–28

    Article  PubMed  Google Scholar 

  21. Mirallie E, Visset J, Sagan C, Hamy A, Le Bodic MF, Paineau J (1999) Localization of cervical node metastasis of papillary thyroid carcinoma. World J. Surg. 23(9):970–973

    Article  CAS  PubMed  Google Scholar 

  22. Machens A, Holzhausen H-J, Dralle H (2004) Skip metastases in thyroid cancer leaping the central lymph node compartment. Arch Surg 139(1):43–45

    Article  PubMed  Google Scholar 

  23. Reddy RM, Grigsby PW, Moley JF, Hall BL (2006) Lymph node metastases in differentiated thyroid cancer under 2 cm. Surgery 140:1050–1054

    Article  PubMed  Google Scholar 

  24. Shah JP, Loree TR, Dharker D, Strong EW, Begg C, Vlamis V (1992) Prognostic factors in differentiated carcinoma of the thyroid gland. Am J Surg 164:62–66

    Article  Google Scholar 

  25. Machens A, Holzhausen HJ, Dralle H (2005) The prognostic value of primary tumour size in papillary and follicular thyroid carcinoma. Cancer 103:2269–2273

    Article  PubMed  Google Scholar 

  26. Russel RCG, Williums NS, Bulstrode CJK (2004) The thyroid gland and the thyroglossal tract. Arnold, London, baily & loves short practice of surgery, pp 716–804

    Google Scholar 

  27. Takashima S, Takayama F, Wang Q, Kobayashi T, Horii A, Yoshida JI (1998) Papillary thyroid carcinoma: mr diagnosis of lymph node metastases. Am J Neuroradiol 19:509–513

    CAS  PubMed  PubMed Central  Google Scholar 

  28. Sakorafas GH, Christodoulou S, Lappas C, Safioleas M (2009) Preoperative detection of cervical lmph node metastases in papillary thyroid cancer: a surgical perspective. Onkologie 32:762–766

    Article  PubMed  Google Scholar 

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  1. Department of Head and Neck Surgery, B Borooah Cancer Institute, House No 10, Gopal Phukan Path, Ajanta Path, Beltola, Guwahati, Assam, 781028, India

    Rajjyoti Das, Tashnin Rahman, Ashok Kumar Das, Kishore Das, Anupam Das, Kaberi Kakati & Rupjyoti Das

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  1. Rajjyoti Das
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  2. Tashnin Rahman
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Das, R., Rahman, T., Das, A.K. et al. Pattern of Nodal Metastasis in Relation to Size of the Primary Tumour in Well-Differentiated Thyroid Carcinoma. Indian J Otolaryngol Head Neck Surg 74 (Suppl 2), 2435–2439 (2022). https://doi.org/10.1007/s12070-020-02167-3

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