Kimura’s Disease: A Diagnostic and Therapeutic Challenge


Kimura’s disease, also known as Eosinophilic Granuloma, is a rare chronic condition seen mainly in Oriental population. It presents with subcutaneous nodules, lymphadenopathy, salivary gland hypertrophy with peripheral eosinophilia and raised serum IgE levels; rarely renal involvement may also be present. Its etiology mainly remains unknown. We present a case series of two patients. Our first case is a middle aged female which presented with a parotid swelling, mimicking a parotid neoplasm. Further investigations revealed associated intra-parotid and cervical lymphadenopathy. An excisional biopsy in the form of Superficial Parotidectomy with lymph node excision was done. Histopathological examination of the excised specimen revealed it to be a case of Kimura’s disease. Our second case, a young adult, presented with a gradually increasing post-auricular swelling. Preliminary investigations in this case pointed towards Kimura’s disease. Excision biopsy of the lesion was done. Histopathological studies confirmed the diagnosis for the same. Both the patients are under our regular follow up and remain disease-free at a follow up of 1 year and 8 months respectively.

This is a preview of subscription content, log in to check access.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8


  1. 1.

    Kimm HT, Szeto C (1937) Eosinophilic hyperplastic lymphogranuloma, comparison with mikulicz’s disease. Chin Med J 23:699–700

    Google Scholar 

  2. 2.

    Dik VK, van der Wiel BA, Vasmel WL (2010) Kimura’s disease of the parotid glands and multiple cervical lymph nodes. Neth J Med 68:175–177

    CAS  PubMed  Google Scholar 

  3. 3.

    Sah P, Kamath A (2013) Kimura’s disease- an unusual presentation involving subcutaneous tissue, parotid gland and lymph node. J Oral Maxillofac Pathol 17(3):455–459

    Article  Google Scholar 

  4. 4.

    Sud K, Saha T, Das A, Kakkar N, Jha V, Kohli HS et al (1996) Kimura’s disease and minimal-change nephrotic syndrome. Nephrol Dial Transplant 11:1349–1351

    CAS  Article  Google Scholar 

  5. 5.

    Suguna BV, Hemalatha M (2014) Kimura’s disease: a case series with literature review. Int J Biomed Res 5:513

    Google Scholar 

  6. 6.

    Larroche C, Bletry O (2005) Kimura’s disease, orphanet encyclopedia. Accessed 1 Dec 2010

  7. 7.

    Meningaud JP, Pitak-Arnnop P, Fouret P, Bertrand JC (2017) Kimura’s disease of the parotid region: report of 2 cases and review of the literature. J Oral Maxillofac Surg 65:134–140

    Article  Google Scholar 

  8. 8.

    Kumar V, Salini, Haridas S (2010) Kimura’s disease: an uncommon cause of lymphadenopathy. Indian J Med Pediatric Oncol 31:89–90

    Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Ankur Gupta.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Gupta, A., Shareef, M., Lade, H. et al. Kimura’s Disease: A Diagnostic and Therapeutic Challenge. Indian J Otolaryngol Head Neck Surg 71, 855–859 (2019).

Download citation


  • Kimura’s disease
  • Intra-parotid lymph nodes
  • Peripheral eosinophilia
  • Serum IgE
  • Superficial parotidectomy