Papillary Thyroid Carcinoma with Cervical Lymph Node Metastasis Arising from Lingual Thyroid

Abstract

Although lingual thyroid is the most common site for ectopic thyroid gland but carcinomas originating from lingual thyroid are extremely rare, accounting only for 1% of all ectopic thyroids. Here we represent a young female with a bleeding mass at the base of her tongue and review the diagnostic approach towards papillary thyroid carcinoma of lingual thyroid. The surgical treatment and follow up are discussed. A combination of radiological studies and histological evaluation should be deployed to investigate suspicious lingual thyroids. The perspective of diagnostic and therapeutic approaches for carcinomas of lingual thyroid is the same as orthotopic thyroid tissue.

This is a preview of subscription content, log in to check access.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

References

  1. 1.

    Braverman LE, Cooper D (2012) Werner & Ingbar’s the thyroid: a fundamental and clinical text. Lippincott Williams & Wilkins, Philadelphia

    Google Scholar 

  2. 2.

    Sturniolo G et al (2016) Differentiated thyroid carcinoma in lingual thyroid. Endocrine 51(1):189–198

    CAS  Article  Google Scholar 

  3. 3.

    Yoo T et al (2016) Thyroglossal duct papillary thyroid carcinoma and synchronous lingual thyroid atypia. Case reports in otolaryngology

  4. 4.

    Pietruszewska W, Wągrowska-Danilewicz M, Józefowicz-Korczyńska M (2014) Papillary carcinoma in thyroglossal duct cyst with uninvolved thyroid. Case report and review of the literature. Arch Med Sci AMS 10(5):1061

    Article  Google Scholar 

  5. 5.

    Jacob MJ, Ravina M (2012) A rare case of lingual thyroid with hyperthyroidism: a case report and review of the literature. Indian J Endocrinol Metab 16(3):441

    Article  Google Scholar 

  6. 6.

    Klubo-Gwiezdzinska J et al (2011) Ectopic cervical thyroid carcinoma—review of the literature with illustrative case series. J Clin Endocrinol Metab 96(9):2684–2691

    CAS  Article  Google Scholar 

  7. 7.

    Bhojwani KM et al (2012) Papillary carcinoma in a lingual thyroid: an unusual presentation. ENT Ear Nose Throat J 91(7):289–291

    Article  Google Scholar 

  8. 8.

    Kennedy TL, Riefkohl WL (2007) Lingual thyroid carcinoma with nodal metastasis. Laryngoscope 117(11):1969–1973

    Article  Google Scholar 

  9. 9.

    Gunn LG (1910) Thyroid tumour. Trans R Acad Med Ire 28:381

    Google Scholar 

  10. 10.

    Rutgers M (1910) Tongstruma. Ned Tijdschr Geeneeskd 1(B):1505

    Google Scholar 

  11. 11.

    Massine RE, Durning SJ, Koroscil TM (2001) Lingual thyroid carcinoma: a case report and review of the literature. Thyroid 11(12):1191–1196

    CAS  Article  Google Scholar 

  12. 12.

    Livolsi VA, Perzin KH, Savetsky L (1974) Carcinoma arising in median ectopic thyroid (including thyroglossal duct tissue). Cancer 34(4):1303–1315

    CAS  Article  Google Scholar 

  13. 13.

    Addams-Williams J, Abo-Khatwa M, Zeitoun H (2007) Papillary carcinoma arising in the lingual thyroid: a case report and review of the literature. Int J Head Neck Surg 2(2). https://ispub.com/IJHNS/2/2/13603

  14. 14.

    Hari CK et al (2009) Follicular variant of papillary carcinoma arising from lingual thyroid. Ear Nose Throat J 88(6):E7

    PubMed  Google Scholar 

  15. 15.

    Raju G, Kameswaran M (2009) Unusual presentations of thyroid malignancies—a case series. Indian J Otolaryngol Head Neck Surg 61(3):230–234

    CAS  Article  Google Scholar 

  16. 16.

    Canciullo D, Motta G (1955) I carcinomi tiroidei della base della lingua. Oto-rino-lar Ital 23:185–211

    CAS  Google Scholar 

  17. 17.

    Mazzaferri EL, Kloos RT (2001) Current approaches to primary therapy for papillary and follicular thyroid cancer. J Clin Endocrinol Metab 86(4):1447–1463

    CAS  Article  Google Scholar 

  18. 18.

    Seoane JM, Cameselle-Teijeiro J, Romero MA (2002) Poorly differentiated oxyphilic (Hürthle cell) carcinoma arising in lingual thyroid: a case report and review of the literature. Endocr Pathol 13(4):353–360

    Article  Google Scholar 

  19. 19.

    Monson JP (2000) The epidemiology of endocrine tumours. Endocr Relat Cancer 7(1):29–36

    CAS  Article  Google Scholar 

  20. 20.

    Noussios G et al (2011) Ectopic thyroid tissue: anatomical, clinical and surgical implications of a rare entity. Eur J Endocrinol 165(3):375–382. https://doi.org/10.1530/EJE-11-0461

    CAS  Article  Google Scholar 

  21. 21.

    Wang C-Y, Chang T-C (1995) Preoperative thyroid ultrasonography and fine-needle aspiration cytology in ectopic thyroid. Am Surg 61(12):1029–1031

    CAS  PubMed  Google Scholar 

  22. 22.

    Weiss SD, Orlich CC (1991) Primary papillary carcinoma of a thyroglossal duct cyst: report of a case and literature review. Br J Surg 78(1):87–89

    CAS  Article  Google Scholar 

  23. 23.

    Bigotti G, Coli A (1997) Follicular carcinoma in lingual thyroid presenting as a latero-cervical mass. Case report and review of the literature. J Oral Pathol Med 26(3):142–146

    CAS  Article  Google Scholar 

  24. 24.

    Cooper DS et al (2009) Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association (ATA) guidelines taskforce on thyroid nodules and differentiated thyroid cancer. Thyroid 19(11):1167–1214

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Maziar Motiee-Langroudi.

Ethics declarations

Conflict of interest

The authors declare that there is no conflict of interest to disclose.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Jalaeefar, A., Motiee-Langroudi, M., Shirkhoda, M. et al. Papillary Thyroid Carcinoma with Cervical Lymph Node Metastasis Arising from Lingual Thyroid. Indian J Otolaryngol Head Neck Surg 71, 762–765 (2019). https://doi.org/10.1007/s12070-018-1539-5

Download citation

Keywords

  • Ectopic thyroid
  • Lingual thyroid
  • Lingual thyroid carcinoma
  • Papillary thyroid carcinoma