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Long Term Oncological Results of Transoral Laser Microsurgery for Early and Moderately Advanced Glottic Carcinoma in Primary and Salvage Settings

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Abstract

The aim of the study is to document the long term oncological results of trans-oral laser microsurgery (TLM) for early and moderately advanced glottic cancer in primary and salvage settings. In this prospective cohort study 43 consecutive patients of glottic cancer (T1–30, T2–7, and selected T3 with mobile cords-6) were recruited. TLM was performed in these 35 primary and 8 previously treated cases. In our series, the local disease control rate with TLM was 90% (27/30) for T1 disease, 71.4% (5/7) for T2 cancer and 66.6% (4/6) for T3 lesions. The overall disease control rates after subsequent treatment for locoregional recurrences were 100% (30/30), 85.7% (6/7) and 83.3% (5/6) for T1, T2, and T3 glottic cancers respectively. The 5-years disease free survival rate for primary cases was 100% and 50% for salvage cases. The 5-years local disease control rate was 96.4% and 41.67% in primary and salvage TLM settings respectively. The 5-years laryngectomy free rates were 96.3% and 18.75% for primary and salvage cases respectively. TLM offers a minimally invasive and oncologically robust treatment option for early glottic cancer with an overall disease free survival of 100% at 5 years noted for primary untreated cases in this experience. TLM for post radiation salvage cases has however been disappointing and alternate larynx preserving option of open partial laryngectomy needs to be considered in this setting.

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Authors and Affiliations

  1. Department of Otolaryngology and Head & Neck Surgery, All India Institute of Medical Sciences, New Delhi, 110029, India

    Prem Sagar, Rajeev Kumar & Alok Thakar

  2. Department of Head and Neck Oncology, Tata Memorial Hospital, Mumbai, 400012, India

    Richa Vaish

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  1. Prem Sagar
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  2. Rajeev Kumar
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  4. Alok Thakar
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Correspondence to Alok Thakar.

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Prem Sagar, Rajeev Kumar, Richa Vaish and Alok Thakar declares that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with institutional ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Sagar, P., Kumar, R., Vaish, R. et al. Long Term Oncological Results of Transoral Laser Microsurgery for Early and Moderately Advanced Glottic Carcinoma in Primary and Salvage Settings. Indian J Otolaryngol Head Neck Surg 70, 463–470 (2018). https://doi.org/10.1007/s12070-018-1505-2

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  • DOI: https://doi.org/10.1007/s12070-018-1505-2

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