Auditory Lateralization Training Effects on Binaural Interaction Component of Middle Latency Response in Children Suspected to Central Auditory Processing Disorder

  • Yones Lotfi
  • Abdollah Moosavi
  • Farzaneh Zamiri AbdollahiEmail author
  • Enayatollah Bakhshi
Original Article


Many children with central auditory processing disorder (C)APD suffer from spatial processing disorder and benefit from binaural processing training including auditory lateralization training. There are subjective tests for evaluating auditory training effects in children with (C)APD but they rely on patient’s attention and cooperation so there is a need for appropriate objective tests. The aim of present study was investigating effects of auditory lateralization training on binaural interaction component (BIC) of middle latency response (MLR). This study was an analytical interventional study. Sixty children suspected to (C)APD (40 boys and 20 girls) were selected based on inclusion criteria and were divided into two groups: control and training group. Auditory lateralization training included 12 formal sessions under headphone by using interaural time difference and performed as a game. MLR (monaural right ear, monaural left ear and binaural) and monaural selective auditory attention test (mSAAT) tests were performed in all the cases. BIC was calculated by subtracting binaural response from summed monaural responses. Covariance test showed that BIC latency decreased and BIC amplitude increased significantly and mSAAT score increased significantly in training group after auditory lateralization training (p value ≤ 0.001). In present study BIC of MLR had potential to show underlying neurophysiologic changes after auditory lateralization training in children suspected to (C)APD objectively. It is in agreement with behavioral improvements after training (mSAAT improvements).


Auditory training Binaural interaction Spatial hearing Middle latency response 


  1. 1.
    Schnupp J, Nelken I, King A (2011) Auditory neuroscience: making sense of sound. MIT Press, CambridgeGoogle Scholar
  2. 2.
    Sonnadara RR, Alain C, Trainor LJ (2006) Occasional changes in sound location enhance middle latency evoked responses. Brain Res 1076(1):187–192PubMedGoogle Scholar
  3. 3.
    Devore S et al (2009) Accurate sound localization in reverberant environments is mediated by robust encoding of spatial cues in the auditory midbrain. Neuron 62(1):123–134PubMedPubMedCentralGoogle Scholar
  4. 4.
    Plack CJ, Moore DR (2010) The oxford handbook of auditory science: hearing, vol 3. Oxford University Press, OXfordGoogle Scholar
  5. 5.
    Labak B (2013) The psychoacoustical bases of spatial hearing in acoustic and electric stimulation. Acoustic Research Institute, Wien.
  6. 6.
    Bodden M (1996) Auditory demonstrations of a cocktail-party-processor. Acta Acust United Acust 82(2):356–357Google Scholar
  7. 7.
    Delphi M et al (2015) Validity and reliability of the Persian version of spatial hearing questionnaire. Med J Islam Repub Iran 29:231PubMedPubMedCentralGoogle Scholar
  8. 8.
    Itoh K et al (2000) Temporal stream of cortical representation for auditory spatial localization in human hemispheres. Neurosci Lett 292(3):215–219PubMedGoogle Scholar
  9. 9.
    Musiek FE, Chermak GD (2013) Handbook of central auditory processing disorder, volume I: auditory neuroscience and diagnosis, vol 1. Plural Pub, San DiegoGoogle Scholar
  10. 10.
    Cherry R (2006) Comparing monotic and diotic selective auditory attention abilities in children. Lang Speech Hear Serv Sch 37(2):137–142PubMedGoogle Scholar
  11. 11.
    Delb W et al (2003) The binaural interaction component (BIC) in children with central auditory processing disorders (CAPD): El componente de interactión binaural (BIC) en niños con desórdenes del procesamiento central auditivo (CAPD). Int J Audiol 42(7):401–412PubMedGoogle Scholar
  12. 12.
    Gomez R, Condon M (1999) Central auditory processing ability in children with ADHD with and without learning disabilities. J Learn Disabil 32(2):150–158PubMedGoogle Scholar
  13. 13.
    Schow RL, Chermak G (1999) Implications from factor analysis for central auditory processing disorders. Am J Audiol 8(2):137–142PubMedGoogle Scholar
  14. 14.
    Cameron S, Dillon H (2007) Development of the listening in spatialized noise-sentences test (LISN-S). Ear Hear 28(2):196–211PubMedGoogle Scholar
  15. 15.
    Cameron S, Glyde H, Dillon H (2012) Efficacy of the LiSN & learn auditory training software: randomized blinded controlled study. Audiol Res 2(1):15Google Scholar
  16. 16.
    Ross-Swain D, Geffner DS (2007) Auditory processing disorders: assessment, management and treatment. Plural Pub, San DiegoGoogle Scholar
  17. 17.
    Cameron S, Dillon H (2008) The listening in spatialized noise-sentences test (LISN-S): comparison to the prototype lisn and results from children with either a suspected (Central) auditory processing disorder or a confirmed language disorder. J Am Acad Audiol 19(5):377–391PubMedGoogle Scholar
  18. 18.
    Cameron S., et al., Remediation of spatial processing issues in CAPD. Handbook of Central Auditory Processing Disorders. Comprehensive Intervention, 2013. 2: p. 201-224Google Scholar
  19. 19.
    Lotfi Y et al (2016) Effects of an auditory lateralization training in children suspected to central auditory processing disorder. J Audiol Otol 20(2):102–108PubMedPubMedCentralGoogle Scholar
  20. 20.
    Jerger J et al (1999) Twin study of central auditory processing disorder. J Am Acad Audiol 10:521–528PubMedGoogle Scholar
  21. 21.
    Jerger J et al (1991) Central auditory processing disorder: a case study. J Am Acad Audiol 2(1):36–54PubMedGoogle Scholar
  22. 22.
    Gopal KV, Pierel K (1999) Binaural interaction component in children at risk for central auditory processing disorders. Scand Audiol 28(2):77–84PubMedGoogle Scholar
  23. 23.
    Strauss DJ, Delb W, Plinkert PK (2004) Analysis and detection of binaural interaction in auditory evoked brainstem responses by time-scale representations. Comput Biol Med 34(6):461–477PubMedGoogle Scholar
  24. 24.
    Leigh-Paffenroth ED, Roup CM, Noe CM (2011) Behavioral and electrophysiologic binaural processing in persons with symmetric hearing loss. J Am Acad Audiol 22(3):181–193PubMedGoogle Scholar
  25. 25.
    Goksoy C, Demirtas S, Ungan P (2004) Dynamics of the contralateral white noise-induced enhancement in the guinea pig's middle latency response. Brain Res 1017(1–2):61–68Google Scholar
  26. 26.
    Nejati V et al (2016) Persian version of the dichotic digit test for children: design and evaluation of the psychometric properties. Audit Vestib Res 25(1):55–62Google Scholar
  27. 27.
    Sanayi R et al (2013) Auditory temporal processing abilities in early azari-persian bilinguals. Iran J Otorhinolaryngol 25(73):227PubMedPubMedCentralGoogle Scholar
  28. 28.
    Aarabi S, Jarollahi F, Sh J (2016) Development and determination of the validity of Persian version of monaural selective auditory attention test in learning disabled children. Audit Vestib Res 25(1):49–54Google Scholar
  29. 29.
    Domitz DM, Schow RL (2000) A new CAPD battery—multiple auditory processing assessmentfactor analysis and comparisons with SCAN. Am J Audiol 9(2):101–111PubMedGoogle Scholar
  30. 30.
    Ebadi E et al (2016) Development and evaluation of the Persian version of the multiple auditory processing assessment. Audit Vestib Res 25(2):75–81Google Scholar
  31. 31.
    Moosavi A et al (2014) Auditory lateralization ability in children with (central) auditory processing disorder. Iran Rehabil J 12(19):70–80Google Scholar
  32. 32.
    Schochat E, Musiek F, Alonso R, Ogata J (2010) Effect of auditory training on the middle latency response in children with (central) auditory processing disorder. Braz J Med Biol Res. 43(8):777–785PubMedGoogle Scholar

Copyright information

© Association of Otolaryngologists of India 2018

Authors and Affiliations

  1. 1.Audiology DepartmentUniversity of Social Welfare and Rehabilitation SciencesTehranIran
  2. 2.Otolaryngology DepartmentIran University of Medical SciencesTehranIran
  3. 3.Biostatistics DepartmentUniversity of Social Welfare and Rehabilitation SciencesTehranIran

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