Skip to main content

Advertisement

SpringerLink
Log in

Multi Centricity of Oral Verrucous Carcinoma: A Case Series of 22 Cases

  • Original Article
  • Published:
Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Verrucous carcinoma (VC) is an uncommon variant of squamous cell carcinoma characterized by proliferative outgrowing clinical appearance of the tumor, Incidence of VC is 2–12 % among oral cancers, the true incidence of VC can be accessed only from surgically treated cases since thorough processing of the entire tumor is necessary for accurate diagnosis, foci of invasive squamous cell carcinoma are found often in the substance of these tumors, thus, over reporting of this tumor is not uncommon. The retrospective data of a tertiary cancer hospital was analysed to understand the clinical challenges and outcome of patients with VC. The frequent association of VC with second primary oral cancer (22.7 %) observed in our series highlights the multi centricity of carcinogenesis in these patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Ackerman LV (1948) Verrucous carcinoma of the oral cavity. Surg 23:670–678

    CAS  Google Scholar 

  2. Koch BB, Trask DK, Hoffman HT, Karnell LH, Robinson RA, Zhen W, Menck HR (2001) National survey of head and neck verrucous carcinoma. Cancer 92(1):110–120

    Article  CAS  PubMed  Google Scholar 

  3. Medina JE, Dichtel W, Luna MA (1984) Verrucous-squamous carcinomas of the oral cavity: a clinicopathologic study of 104 cases. Arch Otolaryngol 110(7):437

    Article  CAS  PubMed  Google Scholar 

  4. Walvekar RR, Chaukar DA, Deshpande MS, Pai PS, Chaturvedi P, Kakade A, D’Cruz AK (2009) Verrucous carcinoma of the oral cavity: a clinical and pathological study of 101 cases. Oral Oncol 45(1):47–51

    Article  PubMed  Google Scholar 

  5. Tornes K, Bang G, Koppang HS, Pedersen KN (1985) Oral verrucous carcinoma. Cancer 46(8):1855–1862

    Google Scholar 

  6. Lübbe J, Kormann A, Adams V, Hassam SH, Grätz KW, Panizzon RG, Burg G (1996) HPV-11-and HPV-16-associated oral verrucous carcinoma. Dermatol 192(3):217–221

    Article  Google Scholar 

  7. Fonts EA, Greenlaw RH, Rush BF, Rovin S (1969) Verrucous squamous cell carcinoma of the oral cavity. Cancer 23(1):152–160

    Article  CAS  PubMed  Google Scholar 

  8. Oliveira DT, de Moraes RV, Fiamengui Filho JF, Neto JF, Landman G, Kowalski LP (2006) Oral verrucous carcinoma: a retrospective study in São Paulo Region. Brazil. Clin Oral Investig 10(3):205–209

    Article  Google Scholar 

  9. Bedi GC, Westra WH, Gabrielson E, Koch W, Sidransky D (1996) Multiple head and neck tumors: evidence for a common clonal origin. Cancer Res 56(11):2484–2487

    CAS  PubMed  Google Scholar 

  10. Worsham MJ, Wolman SR, Carey TE, Zarbo RJ, Benninger MS, van Dyke DL (1995) Common clonal origin of synchronous primary head and neck squamous cell carcinomas: analysis by tumor karyotypes and fluorescence in situ hybridization. Hum Pathol 26(3):251–261

    Article  CAS  PubMed  Google Scholar 

Download references

Conflict of interest

None.

Funding

None.

Author information

Authors and Affiliations

  1. Basavatarakam Indo American Cancer Hospital and Research Centre, Hyderabad, 500034, Andhra Pradesh, India

    Sandhya Gokavarapu, Nagendra Parvataneni, C. R. Charan, Sreenivasa Puthamakula, Ganesh Kulkarni & B. Sridher Reddy

  2. Malla Reddy College of Dental Sciences, Hyderabad, India

    C. R. Charan & Ganesh Kulkarni

  3. Government Dental College and Hospital, Hyderabad, India

    B. Sridher Reddy

Authors
  1. Sandhya Gokavarapu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nagendra Parvataneni
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. R. Charan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sreenivasa Puthamakula
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ganesh Kulkarni
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. B. Sridher Reddy
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sandhya Gokavarapu.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gokavarapu, S., Parvataneni, N., Charan, C.R. et al. Multi Centricity of Oral Verrucous Carcinoma: A Case Series of 22 Cases. Indian J Otolaryngol Head Neck Surg 67, 138–142 (2015). https://doi.org/10.1007/s12070-015-0835-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12070-015-0835-6

Keywords

Search

Navigation