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Evaluation of MMP-9 and TIMP-1 Levels of the Patients with Nasal Polyposis After Corticosteroid Therapies

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Abstract

The aim of this study is to evaluate the effects of intrapolyp, systemic and local corticosteroid treatment modalities on MMP-9 and TIMP-1 level in polyp tissues. This study included 71 patients and five groups. Group A treated with oral methylprednisolone, Group B, treated with topical steroid spray, Group C treated with intralesional triamcinolone acetonide, Group D patients with nasal polyposis who has not given any medication, Group E had surgery for concha bullosa without nasal polyp disease. Samples from group A were collected endoscopically 1 day after treatment was stopped. Group B samples were collected at the end of the first month. Video guided sample collection from Group C was also performed on the 7th day after treatment. MMP-9 and TIMP-1 levels were measured by Enzyme-linked immunosorbent assay method. When we compared the MMP-9 levels of all groups, there were no significant differences. There was significant difference of TIMP-1 level between Groups C and E (pC–E = 0.0019), however there was no difference among the level of the other groups. When MMP-9/TIMP1 rates of all groups were compared, there were significant difference between Group A and D (pA–D = 0.005) and between Group A and E, also between Group C and E. Our study is the first study to evaluate the effects of different corticosteroid treatment modalities on MMP-9 and TIMP-1 in nasal polyps and concluded that corticosteroid did not do a significant impact on this pathway.

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Acknowledgments

Authors wish to thank Özlem Köksal for statistical analysis of data, and epidemiological committee and its chief Mustafa Gultepe Prof. for scientific support.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, GATA Haydarpasa Training Hospital, Uskudar, 34668, Istanbul, Turkey

    Hakan Cincik, Evren Erkul, Dogan Pinar, Atila Gungor, Engin Cekin & Adem Cakmak

  2. Department of Biochemistry, GATA Haydarpasa Training Hospital, Uskudar, Istanbul, Turkey

    Osman Ipcioglu

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  1. Hakan Cincik
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  2. Evren Erkul
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  3. Dogan Pinar
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  4. Osman Ipcioglu
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  5. Atila Gungor
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  6. Engin Cekin
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  7. Adem Cakmak
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Correspondence to Evren Erkul.

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Cincik, H., Erkul, E., Pinar, D. et al. Evaluation of MMP-9 and TIMP-1 Levels of the Patients with Nasal Polyposis After Corticosteroid Therapies. Indian J Otolaryngol Head Neck Surg 65 (Suppl 2), 445–449 (2013). https://doi.org/10.1007/s12070-013-0656-4

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  • DOI: https://doi.org/10.1007/s12070-013-0656-4

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