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Oral Sex and HPV: Population Based Indications

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Human pappilloma virus (HPV) is well established in etiology of uterine cervical cancers, but its role in head and neck cancer is strongly suggested through many epidemiological and laboratory studies. Although HPV-16 induced oropharyngeal cancer is a distinct molecular entity, its role at other sub-sites (oral cavity, larynx, nasopharynx, hypopharynx) is less well established. Oral sex is supposedly the most commonly practiced unnatural sex across the globe and may prove to be a potential transmitting link between cancers of the uterine cervix and the oropharynx in males particularly in those 10–15% non-smokers. In India with the second largest population (higher population density than China) the oral sex is likely to be a common ‘recreation-tool’ amongst the majority (poor) and with the concurrent highly prevalent bad cervical/oral hygiene the HPV is likely to synergize other carcinogens. Hence in accordance (or coincidently), in India the cervical cancer happens to be the commonest cancer amongst females while oral/oropharyngeal cancer amongst males. Oral sex as a link between these two cancer types, can largely be argued considering a poor level of evidence in the existing literature. The modern world has even commercialized oral sex in the form of flavored condoms. The inadequate world literature currently is of a low level of evidence to conclude such a relationship because no such specific prospective study has been carried out and also due to wide (and unpredictable) variety of sexual practices, such a relationship can only be speculated. This article briefly reviews the existing literature on various modes and population based indications for HPV to be implicated in head and neck cancer with reference to oral sexual practice.

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References

  1. Lakshmi S, Nair SA, Pillai MR (1993) Oral cancer and human papilloma viruses: is there a link. J Surg Oncol 52(3):193–196

    Article  CAS  PubMed  Google Scholar 

  2. Klussmann JP, Weissenborn SJ, Weiland U, Dries V, Kolligs J, Jungehuelsing M et al (2001) Prevalence, distribution and viral load of human papilloma virus 16 DNA in tonsillar carcinomas. Cancer 92:2875–2884

    Article  CAS  PubMed  Google Scholar 

  3. Steenbergen RD, Hermsen MA, Walboomers JM, Joenje H, Arwert F, Meijer CJ et al (1995) Integrated human papilloma virus type 16 and loss of heterozygosity at 11q22 and 18q21 in oral carcinoma and its derivative cell line. Cancer Res 55:5465–5471

    CAS  PubMed  Google Scholar 

  4. Herrero R (2003) Human papilloma virus and cancer of the upper aerodigestive tract. Monographs. chap 7. Journal National Cancer Institute 31:47-51

    Google Scholar 

  5. Clayman GL, Stewart MG, Weber RS, el-Naggar AK, Grimm EA (1994) Human papilloma virus in laryngeal and hypopharyngeal carcinomas. Relationship to survival. Arch Otolaryngol Head Neck Surg 120:743–748

    Article  CAS  PubMed  Google Scholar 

  6. Venuti A, Manni V, Morello R, De Marco F, Marzetti F, Marcante ML (2000) Physical state and expression of human papilloma virus in laryngeal carcinomaand surrounding normal mucosa. J Med Virol 60:396–402

    Article  CAS  PubMed  Google Scholar 

  7. Capone RB, Pai SI, Koch WM, Gillison ML, Danish HN, Westra WH et al (2000) Detection and quantitation of HPV DNA in the sera of patients with HPV associated head and neck squamous cell carcinoma. Clin Cancer Res 11:489–495

    Google Scholar 

  8. Kellokoski JK, Syrjanen SM, Chang F, Yliskoski M, Syrjanen KJ (1992) Southern blot hybridization and PCR in detection of oral human papilloma virus (HPV) infections in women with genital HPV infections. J Oral Pathol Med 21:459–464

    Article  CAS  PubMed  Google Scholar 

  9. Sun JD, Weatherly RA, Koopmann CF, Carey TE (2000) Mucosal swabs detect HPV in laryngeal papillomatosis patients but not family members. Int J Pediatric Otorhinolaryngol 53:95–103

    Article  CAS  Google Scholar 

  10. Maden C, Beckmann AM, Thomas DB et al (1992) Human papilloma viruses, herpes simplex viruses and the risk of oral cancer in men. Am J Epidemiol 135:1093–1102

    CAS  PubMed  Google Scholar 

  11. Schwartz SM, Daling JR, Doody DR, Wipf GC, Carter JJ, Madeleine MM et al (1998) Oral cancer risk in relation to sexual history and evidences of HPV infection. J Natl Cancer Inst 90:1626–1636

    Article  CAS  PubMed  Google Scholar 

  12. Smith EM, Hoffman HT, Summersgill KS, Kirchner HL, Turek LP, Haugen TH (1998) Human papillomavirus and risk of oral cancer. Laryngoscope 108:1098–1103

    Article  CAS  PubMed  Google Scholar 

  13. Talamini R, Vaccarella S, Barbone F et al (2000) Oral hygiene, dentition, sexual habits and risk of oral cancer. Br J Cancer 83:1238–1242

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Garrote LF, Herrero R, Reyes RM et al (2001) Risk factors for cancer of the oral cavity and oropharynx in Cuba. Br J Cancer 85:46–54

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  15. Ritchie JM, Smith EM, Summersgill KF et al (2003) Human papillomavirus infection as a prognostic factoring carcinomas of oral cavity and oropharynx. Int J Cancer 104:336–344

    Article  CAS  PubMed  Google Scholar 

  16. Winer RL, Lee SK, Hughes JP, Adam DE, Kiviat NB, Koutsky LA (2003) Genital human papilloma infection: incidence and risk factor in a cohort of female university students. Am J Epidemiol 157:218–226

    Article  PubMed  Google Scholar 

  17. Kreimer AR, Alberg AJ, Viscidi R, Gillison ML (2004) Gender differences in sexual biomarkers and behaviours associated with human papillomavirus 16, 18, 33 seroprevalence. Sex Transm Dis 31(4):247–256

    Article  PubMed  Google Scholar 

  18. Sturgis EM (2005) Human pappilloma virus and head and neck cancer. The University of Texas–MD Anderson Cancer center Institutional Grand Rounds, Houston

  19. Edwards S, Carne C (1998) Oral sex and transmission of viral STIs. Sex Transm Infect 74:6–10

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Volter C, He Y, Delius H, Roy-Burman A, Greenspan JS, Greenspan D et al (1996) Novel HPV types present in oral papillomatous lesions from patients with HIV infection. Int J Cancer 66:453–456

    Article  CAS  PubMed  Google Scholar 

  21. Svare EI, Kajaer SK, Nonnenmacher B et al (1997) Seroreactivity to human papilloma virus type 16 virus-like particles is lower in high-risk men than in high-risk women. J Infect Dis 176:876–883

    Article  CAS  PubMed  Google Scholar 

  22. Coutlee F, Trottier AM, Ghattas G et al (1997) Risk factors for oral human papilloma virus in adults infected and not infected with human immunodeficiency virus. Sex Transm Dis 24:23–31

    Article  CAS  PubMed  Google Scholar 

  23. Palefsky JM, Holly EA, Hogeboom CJ et al (1998) Virologic, immunologic and clinical parameters in the incidence and progression of anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual men. J AIDS Hum Retrovir 17:314–319

    CAS  Google Scholar 

  24. Palefsky JM, Holly EA, Ralston ML, Da Costa M, Greenblatt RM (2001) Prevalence and risk factors for anal human papillomavirus infection in human immunodeficiency virus (HIV)-positive and high-risk HIV-negative women. J Infect Dis 183:383–391

    Article  CAS  PubMed  Google Scholar 

  25. Ahdieh L, Klein RS, Burk R et al (2001) Prevalence, incidence and type-specific persistence of human papillomavirus in human immunodeficiency virus (HIV)-positive and HIV-negative women. J Infect Dis 184:682–690

    Article  CAS  PubMed  Google Scholar 

  26. Palefsky JM, Minkoff H, Kalish LA et al (1999) Cervicovaginal human papilloma virus infection in human immunodeficiency virus-1 (HIV)-positive and high-risk HIV-negative women. J Natl Cancer Inst 91:226–236

    Article  CAS  PubMed  Google Scholar 

  27. de Sanjose S, Palefsky J (2002) Cervial and anal HPV infections in HIV positive women and men. Virus Res 89:201–211

    Article  PubMed  Google Scholar 

  28. Dillner J, Kallings I, Brihmer C et al (1996) Seropositives to human papilloma virus types 16, 18 or 33 capsids and to Chlamydia trachomatis are markers of sexual behaviour. J Infect Dis 173:1394–1398

    Article  CAS  PubMed  Google Scholar 

  29. Moscicki AB, Hills N, Shiboski S et al (2001) Risks for incident human papilloma virus infection and low grade squamous intraepithelial lesion development in young females. JAMA 285:2995–3020

    Article  CAS  PubMed  Google Scholar 

  30. Smith JS, Herrero R, Bosetti C et al (2002) Herpes simplex virus-2 as a human papilloma virus cofactor in the etiology of invasive cervical cancer. J Natl Cancer Inst 94:1604–1613

    Article  CAS  PubMed  Google Scholar 

  31. Jones C (1995) Cervical cancer: is herpes simplex virus type II a cofactor? Clin Microbiol Rev 8:549–556

    CAS  PubMed Central  PubMed  Google Scholar 

  32. Hara Y, Kimoto T, Okuno Y, Minekawa Y et al (1997) Effect of herpes simplex virus of the DNA of human papilloma virus 18. J Med Virol 53:4–12

    Article  CAS  PubMed  Google Scholar 

  33. Tra-Thanh D, Provencher D, Koushik A et al (2003) Herpes simplex virus type II is not a cofactor to human papilloma virus in cancer of the uterine cervix. Am J Obstet Gynecol 188:129–134

    Article  Google Scholar 

  34. Kjellberg L, Wang Z, Wiklund F et al (1999) Sexual behavior and papillomavirus exposure in cervical intraepithelial neoplasia: A population based case-control study. J Gen Virol 80(part 2):391–398

    CAS  PubMed  Google Scholar 

  35. Tachezy R, Hamsikova E, Hajek T et al (1999) Human papilloma virus genotype spectrum in Czech women: correlation of HPV DNA presence with antibodies against HPV-16, 18 & 33 virus like particles. J Med Virol 58:378–386

    Article  CAS  PubMed  Google Scholar 

  36. Carter JJ, Koutsky LA, Wipf GC et al (1996) The natural history of human papillomavirus type 16 capsid antibodies among a cohort of university women. J Infect Dis 174:927–936

    Article  CAS  PubMed  Google Scholar 

  37. Touze A, de Sanjose S, Coursaget P et al (2001) Prevalence of anti-human papilloma virus type 16, 18 31 & 58 virus like particles in women in the general population and prostitutes. J Clin Microbiol 39:4344–4348

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  38. Halperin DT (1999) Heterosexual anal intercourse: prevalence, cultural factors and HIV infection and other health risks, Part I. Aids Patient Care and STDs 13(12):717–730

    Article  CAS  PubMed  Google Scholar 

  39. Kumar B, Ross MW (1991) Sexual behaviour and HIV infection risks in Indian homosexual men: a cross cultural comparison. Int J STD AIDS 2:442–444

    CAS  PubMed  Google Scholar 

  40. Mehendale SM (1998) HIV infection amongst persons with high risk behaviour in Pune city: update on findings from a prospective cohort study. AIDS Res Rev 1:2–9

    Google Scholar 

  41. Rodrigues JJ, Mehendale SM, Shepard ME et al (1995) Risk factors for HIV infection in people attending clinics for sexually transmitted in India. Br Med J 311:283–286

    Article  CAS  Google Scholar 

  42. Seabrook J, Gopalan A (1999) Love in different climate: men have sex with men in India. Verso Books, New York

    Google Scholar 

  43. Menda RK, Chulani HL, Yawalkar SJ, Kulkarni BS (1971) Venereal disease of the anal region. Dis Colon Rectum 14:454–459

    Article  CAS  PubMed  Google Scholar 

  44. Arauz R, Ortells P, Antonietta M, Guevara M, Shedin M (1997) Sexo Inseguro. Fundacion Nimehuatzin, Managua

    Google Scholar 

  45. Parker R (1991) Bodies, pleasures and passions: Sexual culture in contemporary Brazil. Beacon, Boston

    Google Scholar 

  46. Parkin DM, Whelan SL, Ferlay J, Teppo L, Thomas DB (eds) Cancer incidence in five continents, vol VIII. IARC Scientific Publications No. 155. International Agency for research on Cancer, Lyon

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  1. Department of Otolaryngology, King George’s Medical College (CSMMU), Lucknow, UP, India

    Anupam Mishra & Veerendra Verma

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  1. Anupam Mishra
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  2. Veerendra Verma
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Correspondence to Anupam Mishra.

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Mishra, A., Verma, V. Oral Sex and HPV: Population Based Indications. Indian J Otolaryngol Head Neck Surg 67 (Suppl 1), 1–7 (2015). https://doi.org/10.1007/s12070-012-0521-x

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