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Tumor-Associated Tissue Eosinophilia as a Prognostic Factor in Squamous Cell Carcinoma of the Larynx

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Abstract

Inflammatory infiltration with eosinophilia in or around the tumoral tissue varies among the cases with invasive squamous cell carcinoma of the larynx. The aim of this study was to investigate the possible role of the tumor-associated tissue eosinophilia (TATE) as a predictive factor for the metastatic status in laryngeal squamous cell carcinoma in patients who had neck dissections. One hundred consecutive specimens from the patients who had been treated surgically for invasive squamous cell carcinoma of the larynx were re-evaluated in terms of TATE. Based on the eosinophil counts per 10 high power field (HPF), the cases were grouped into three different categories (I, II, III) according to three different cut off values (A, B, C). The number of eosinophil cells per 10 HPF for the groups were defined as: IA: 0–10; IB: 11–29; IC: 30 and greater; IIA: 0–20; IIB: 21–39; IIC: 40 and greater; IIIA: 0–30; IIIB: 31–49; IIIC: 50 and greater. Statistical significance between tissue eosinophil counts of the metastatic and non-metastatic lymph node groups were evaluated. This study comprised 97 male and three female patients with squamous cell carcinoma of the larynx (mean age 59.9). Forty-five were well differentiated, 50 were moderately differentiated and five were poorly differentiated invasive squamous cell carcinoma. At least one lymph node metastasis was observed in 34 cases. Eosinophil counts varied between 1 and 138 per 10 HPF in the tumor and/or peritumoral areas. In the three distinct categories with three different cut off values of eosinophil cell counts among nonmetastatic cases and cases with lymph node metastasis, correlation of eosinophil counts with lymph node metastasis were statistically insignificant (Crosstabs, χ2). Although in the series, numerical values of the TATE seem to be increased in patients with laryngeal squamous cell carcinoma with lymph node metastasis, this fact has not been confirmed with statistical analysis.

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References

  1. Crissman JD, Zarbo RJ (1989) Dysplasia, in situ and progression to invasive squamous cell carcinoma of the upper aerodigestive tract. Am J Surg Pathol 13:5–16

    PubMed  Google Scholar 

  2. Barnes L, Everson JW, Reichart P, Sidransky D (2005) WHO classification of tumours. Pathology and genetics of head and neck tumors. IARC Press, Lyon, pp 109–121

    Google Scholar 

  3. Ercan I, Cakir B, Başak T, Ozdemir T, Sayin I, Turgut S (2005) Prognostic significance of stromal eosinophilic infiltration in cancer of the larynx. Otolaryngol Head Neck Surg 132(6):869–873

    Article  PubMed  Google Scholar 

  4. Pasternak A, Jansa P (1984) Local eosinophilia in stroma of tumors related to prognosis. Neoplasma 31:323–326

    Google Scholar 

  5. Lowe D, Fletcher CDM (1984) Eosinophilia in squamous cell carcinoma of the oral cavity, external genitalia and anus-clinical correlations. Histopathology 8:627–632

    Article  CAS  PubMed  Google Scholar 

  6. Caruso RA, Giuffre G, Inferrea C (1993) Minute and small early gastric carcinoma with special reference to eosinophil infiltration. Histopathology 8:155–156

    CAS  Google Scholar 

  7. Tadbir AA, Ashraf MJ, Sardari Y (2009) Prognostic significance of stromal eosinophilic infiltration in oral squamous cell carcinoma. J Craniofac Surg 20(2):287–289

    Article  PubMed  Google Scholar 

  8. Tostes Oliveira D, Tjioe KC, Assao A, Sita Faustino SE, Lopes Carvalho A, Landman G et al (2009) Tissue eosinophilia and its association with tumoral invasion of oral cancer. Int J Surg Pathol 17(3):244–249

    Article  PubMed  Google Scholar 

  9. Falconieri G, Luna MA, Pizzolitto S, DeMaglio G, Angione V, Rocco M (2008) Eosinophil-rich squamous carcinoma of the oral cavity: a study of 13 cases and delineation of a possible new microscopic entity. Ann Diagn Pathol 12:322–327

    Article  PubMed  Google Scholar 

  10. Horie N, Shimoyama T, Kaneko T, Ide F (2007) Multiple oral squamous cell carcinomas with blood and tissue eosinophilia. J Oral Maxillofac Surg 65:1648–1650

    Article  PubMed  Google Scholar 

  11. Alkhabuli JO, High AS (2006) Significance of eosinophil counting in tumor associated tissue eosinophilia (TATE). Oral Oncol 42:849–850

    Article  CAS  PubMed  Google Scholar 

  12. Said M, Wiseman S, Yang J, Alrawi S, Douglas W, Cheney R et al (2005) Tissue eosinophilia: a morphologic marker for assessing stromal invasion in laryngeal squamous neoplasms. BMC Clin Pathol 5(1):1

    Article  PubMed Central  PubMed  Google Scholar 

  13. Deron P, Goossens A, Halama AR (1996) Tumour-associated tissue eosinophilia in head and neck squamous-cell carcinoma. ORL J Otorhinolaryngol Relat Spec 58:167–170

    Article  CAS  PubMed  Google Scholar 

  14. Thompson AC, Bradley PJ, Griffin NR (1994) Tumour-associated tissue eosinophilia and long term prognosis for carcinoma of the larynx. Am J Surg 168:469–471

    Article  CAS  PubMed  Google Scholar 

  15. Sassler AM, McClatchey KD, Wolf GT, Fisher SG (1995) Eosinophilic infiltration in advanced laryngeal squamous cell carcinoma. Laryngoscope 105:413–416

    Article  CAS  PubMed  Google Scholar 

  16. Przeworski E (1896) Über die lokale Eosinophilie beim Krebs nebst Bemerkungen über die bedeutung der eosinophilen Zellen im allgemeinen. Zentralbl Allg Pathol Anat 5:177–191

    Google Scholar 

  17. Lowe D, Fletcher CD, Shaw MP, McKee PH (1984) Eosinophil infiltration in keratoacanthoma and squamous cell carcinoma of the skin. Histopathology 8(4):619–625

    Article  CAS  PubMed  Google Scholar 

  18. Jong EC, Klebanoff SJ (1980) Eosinophil-mediated mammalian tumor cell cytotoxicity: role of the peroxidase system. J Immunol 124:1949–1953

    CAS  PubMed  Google Scholar 

  19. Looi L (1987) Tumor associated tissue eosinophilia in nasopharyngeal carcinoma. A pathologic study of 422 primary and 138 metastatic tumors. Cancer 59:466–470

    Article  CAS  PubMed  Google Scholar 

  20. McGavran MH, Bauer WC, Ogura JH (1961) The incidence of cervical lymph node metastasis from epidermoid carcinoma of the larynx and their relationship to certain characteristics of the primary tumor. A study based on the clinical and pathological findings for 96 patients treated by primary en bloc laryngectomy and radical neck dissection. Cancer 14:55–66

    Article  CAS  PubMed  Google Scholar 

  21. Yılmaz T, Hosal AS, Gedikoglu G, Kaya S (1999) Prognostic significance of histopathological parameters in cancer of the larynx. Eur Arch Otolaryngol 256:139–144

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Tepecik Research and Training Hospital, Izmir, Turkey

    D. Etit, B. G. Yardım, Ü. Bayol & N. Ş. Korkmaz

  2. Department of Otolaryngology, Atatürk Research and Training Hospital, İzmir Atatürk Eğitim ve Araştırma Hastanesi 1. KBB Kliniği, Basın Sitesi, Izmir, Turkey

    S. Arslanoğlu & S. Öztürkcan

  3. Department of Otolaryngology, Tepecik Research and Training Hospital, Izmir, Turkey

    İ. Çukurova

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  1. D. Etit
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  2. B. G. Yardım
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  3. S. Arslanoğlu
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  4. Ü. Bayol
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Correspondence to S. Arslanoğlu.

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Etit, D., Yardım, B.G., Arslanoğlu, S. et al. Tumor-Associated Tissue Eosinophilia as a Prognostic Factor in Squamous Cell Carcinoma of the Larynx. Indian J Otolaryngol Head Neck Surg 66 (Suppl 1), 186–190 (2014). https://doi.org/10.1007/s12070-011-0417-1

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  • DOI: https://doi.org/10.1007/s12070-011-0417-1

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