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Prospective Randomized Comparison of Mitomycin C Application in Endoscopic and External Dacryocystorhinostomy

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Abstract

The aim of the study is to compare the subjective (relief of symptoms) and objective (endoscopic visualization of ostium patency at the time of syringing) outcomes at the end of two procedures—Endonasal DCR versus External DCR with Mitomycin C and to assess the role of Mitomycin C in maintaining patency of nasolacrimal drainage system. Prospective randomized comparative study was performed. Thirty-five patients were enrolled in each endoscopic and external dacryocystorhinostomy groups with Mitomycin C (MMC) application. The 37 eyes underwent endonasal DCR (28 unilateral primary eyes + 1 bilateral primary eyes + 5 unilateral revision eyes + 1 bilateral revision eye) while 35 eyes underwent external DCR (34 unilateral primary eyes + 1 unilateral revision eye). Mitomycin C 0.2 mg/ml was applied intra-operatively for 5 min to the ostium site at the end of endonasal or external DCR procedure. Objective assessment by syringing at the end of 1 year in the endonasal group showed 35 eyes (94%) were patent, 1 (3%) was partially blocked and 1(3%) was completely blocked; while in external group all 35 eyes (100%) were patent. Endoscopic visualization of the ostium at the time of syringing showed only one eye (3%) in the endonasal group was blocked while all the other eyes in both groups were patent. Both groups had a mean follow-up of 6–36 months. No complications were associated with use of Mitomycin C. In conclusion, intra-operative use of Mitomycin C in both endoscopic DCR and external DCR is safe and effective in increasing the success rate.

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Authors and Affiliations

  1. Department of Ophthalmology, KLE University’s Jawaharlal Nehru Medical College, Belgaum, Karnataka, India

    Rekha R. Mudhol

  2. Department of ENT and HNS, KLE University’s Jawaharlal Nehru Medical College, Belgaum, Karnataka, India

    N. D. Zingade, R. S. Mudhol, Anil S. Harugop & Amal T. Das

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  1. Rekha R. Mudhol
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  2. N. D. Zingade
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  3. R. S. Mudhol
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  4. Anil S. Harugop
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  5. Amal T. Das
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Correspondence to Rekha R. Mudhol.

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Mudhol, R.R., Zingade, N.D., Mudhol, R.S. et al. Prospective Randomized Comparison of Mitomycin C Application in Endoscopic and External Dacryocystorhinostomy. Indian J Otolaryngol Head Neck Surg 65 (Suppl 2), 255–259 (2013). https://doi.org/10.1007/s12070-011-0409-1

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  • DOI: https://doi.org/10.1007/s12070-011-0409-1

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