Skip to main content

Advertisement

SpringerLink
Log in

Pre- and Postovulatory Auditory Brainstem Response in Normal Women

  • Original Article
  • Published:
Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

Studies with ovarian hormones on auditory brainstem response (ABR) have conflicting reports although women have ABR shorter than men. This study compared ABR between pre- and postovulatory phases of menstrual cycle in consenting 40 healthy female volunteers (age 19 ± 2.35 years). The study was conducted under standard laboratory conditions (room temperature 26 ± 2°C) using Neuropack (Nihon Kohden machine, NM-420S; H636, Japan) and earphone dynamic receiver ELEGA (Type DR-531; no.237, Japan) in sound proof room. Ears were stimulated simultaneously using standard protocol. ABR was recorded in pre- and postovulatory phases. Ovulation was estimated by measuring basal body temperature. The ABR wave latencies (WLs) I, II, III, IV, V and inter-peak latencies (IPLs) I–III, III–V, I–V were compared between the two phases of menstrual cycle using paired t test. The postovulatory phase had shorter WL V (5.71 ± 0.18 ms vs. 5.81 ± 0.19 ms, p < 0.01), IPL III–V (1.89 ± 0.16 ms vs. 1.94 ± 0.19 ms, p < 0.05), and I–V (3.88 ± 0.16 ms vs. 3.95 ± 0.18 ms, p < 0.05) than in preovulatory. Other WLs and IPLs showed decreasing trend in postovulatory phase. ABR is better in postovulatory phase as compared to preovulatory phase probably due to progesterone hormone which might be involved in modulating auditory hearing pathway at postovulatory phase.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Don M, Ponton CW, Eggermont JJ, Masuda A (1994) Auditory brainstem response (ABR) peak amplitude variability reflects individual differences in cochlear response times. J Acoust Soc Am 96(6):3476–3491

    Article  CAS  PubMed  Google Scholar 

  2. Patterson JV, Michalewski HJ, Thompson LW, Bowman TE, Litzelman DK (1981) Age and sex differences in the human auditory brainstem response. J Gerontol 36(4):455–462

    Article  CAS  PubMed  Google Scholar 

  3. Luders HO, Terada K (2000) Auditory evoked potentials. In: Levin KH, Luders HO (eds) Comprehensive clinical neuro physiology. WB Saunders, USA, pp 525–539

    Google Scholar 

  4. Dehan CP, Jerger J (1990) Analysis of gender differences in the auditory brainstem response. Larygoscope 100(1):18–24

    Article  CAS  Google Scholar 

  5. Ben David Y, Tal J, Podoshin L, Fradis M, Sharf M, Pratt H, Faraggi D (1995) Brain stem auditory evoked potentials: effects of ovarian steroids correlated with increased incidence of Bell’s palsy in pregnancy. Otolaryngol Head Neck Surg 113(1):32–35

    Article  CAS  PubMed  Google Scholar 

  6. Yadav A, Tandon OP, Vaney N (2002) Auditory evoked responses during different phases of menstrual cycle. Indian J Physiol Pharmacol 46(4):449–456

    PubMed  Google Scholar 

  7. Zani A (1989) Brainstem evoked responses reflect information processing changes with the menstrual cycle in young female athletes. J Sports Med Phys Fitness 29(1):113–121

    CAS  PubMed  Google Scholar 

  8. Elkind-Hirsch KE, Wallace E, Malinak LR, Jerger JJ (1994) Sex hormones regulate ABR latency. Otolaryngol Head Neck Surg 110(1):46–52

    Article  CAS  PubMed  Google Scholar 

  9. Elkind-Hirsch KE, Wallace E, Stach BA, Jerger JF (1992) Cyclic steroid replacement alters auditory brainstem responses in young women with premature ovarian failure. Hear Res 64(1):93–98

    Article  CAS  PubMed  Google Scholar 

  10. Serra A, Maiolino L, Agnello C, Messina A, Caruso S (2003) Auditory brain stem response throughout the menstrual cycle. Ann Otol Rhinol Laryngol 112(6):549–553

    PubMed  Google Scholar 

  11. Khaliq F, Tandon OP, Goel N (2005) Differential effects of exogenous estrogen versus estrogen-progesteron combination on auditory evoked potential in menopausal women. Indian J Physiol Pharmacol 49(3):345–352

    PubMed  Google Scholar 

  12. Caruso S, Cianci A, Grasso D, Agnello C, Galvani F, Maiolino L, Serra A (2000) Auditory brainstem response in postmenopausal women treated with hormone replacement therapy: a pilot study. Menopause 7(3):178–183

    Article  CAS  PubMed  Google Scholar 

  13. Caruso S, Maiolino L, Agnello C, Garozo A, Mari DL, Serra A (2003) Effects of patch or gel estrogen therapies on auditory evoked response in surgically post menopausal women: a prospective, randomized study. Fertil Steril 79(3):556–561

    Article  PubMed  Google Scholar 

  14. Caruso S, Maiolino L, Rugolo S, Intelisano G, Farina M, Cocuzza S, Serra A (2003) Auditory brain stem response in premenopausal women taking oral contraceptives. Hum Reprod 18(1):85–89

    Article  CAS  PubMed  Google Scholar 

  15. Hultcrantz M, Simonoska R, Stenberg AE (2006) Estrogen and hearing: a summary of recent investigations. Acta Otolaryngol 126:10–14

    Article  CAS  PubMed  Google Scholar 

  16. Boyles S (2006) Hormone therapy may damage hearing study: Hormone replacement therapy with progestin harms hearing; some skeptical [online]. http://www.webmd.com/menopause/news/20060905/hormone-therapy-damage-hearing. Accessed 3 November 2008

  17. Smith YR, Giordani B, Lajiness-o`Neill R, Zubieta JK (2001) Long term estrogen replacement is associated with improved non verbal memory and attentional measures in postmenopausal women. Fertil Steril 76(6):1101–1107

    Article  CAS  PubMed  Google Scholar 

  18. Garcia-Segura LM, Azcoitia I, DonCarlos LL (2001) Neuroprotection by estradiol. Prog Neurobiol 63:29–60

    Article  CAS  PubMed  Google Scholar 

  19. HRT may accelerate hearing loss in women [online]. http://www.webmd.com/menopause/news/20040225/hrt-may-accelerate-hearing-loss-in-women. Accessed 25 Feb 2004 [cited on 2007 Jan 3]

  20. Nodal A, Diaz M, Valverde MA (2001) The estrogen trinity: membrane, cytosolic and nuclear effects. News Physiol Sci 16:251–255

    Google Scholar 

  21. Yadav A, Tandon OP, Vaney N (2003) Long latency auditory evoked responses in ovulatory and anovulatory menstrual cycle. Indian J Physiol Pharmacol 47(2):179–184

    PubMed  Google Scholar 

  22. Abdelmalek M (2007) Protecting the Brain with Progesterone: Progesterone treatment may provide answer for acute traumatic brain injury [online]. http://abcnews.go.com/Health/Story?id=3222040&page=1. Accessed 6 Nov 2008

  23. Laugel GR, Dengerink HA, Wright JW (1987) Ovarian steroid and vasoconstrictor effects on cochlear blood flow. Hear Res 31:245–251

    Article  CAS  PubMed  Google Scholar 

  24. Heatherton TF, Kozlowski LT, Frecker RC, Fagerstrom KO (1991) The fragestrom test for nicotine dependence: a revision of the fagerstrom tolerance questionnaire. British J of Addictions 86:1119–1127

    Article  CAS  Google Scholar 

  25. Babor FT, Higgins-Biddle CJ, Saunders BJ, Monteiro GM (2001) AUDIT: The alcohol use disorders identification test: Guidelines for use in primary care (2nd ed).WHO/MSD/MSB/01.6a. Accessed 24 June 2006

  26. Killicdag EB, Yavuz H, Bagis T, Tarim E, Erkan AN, Kazanci F (2004) Effects of estrogen therapy on hearing in post menopausal women. Am J Obstet Gynecol 190:77–82

    Article  Google Scholar 

  27. Tasman A, Hahn T, Maiste A (1999) Menstrual cycle synchronized changes in brain stem auditory evoked potentials and visual evoked potentials. Biol Psychiatry 45(11):1516–1519

    Article  CAS  PubMed  Google Scholar 

  28. Kaur P, Jodhka PK, Underwood WA, Bowles CA, de Fiebre NC, de Fiebre CM, Singh MY (2007) Progesterone increases brain- derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase- dependent manner in cerebral cortical explants. J Neurosci Res 85(11):2441–2449

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  29. Henderson VW, Paganini-Hill A, Miller BL, Elble RJ, Reyes PF, Sharpe D et al (2006) Estrogen for Alzheimer’s disease in women: randomized, double-blind, placebo-controlled trial. Neurology 54:295–301

    Article  Google Scholar 

  30. David S (1996) Sudden sensorineural deafness and hormone replacement therapy. J laryngol otol 110:1148–1150

    Google Scholar 

  31. Ciriza I, Azcoitia I, Garcia-Segura LM (2004) Reduced progesterone metabolites protect rat hippocampal neurones from kainic acid excitotoxicity in vivo. J Neuroendocrinol 16(1):58–63

    Article  CAS  PubMed  Google Scholar 

  32. Wright DW, Bauer ME, Hoffman SW, Stein DG (2001) Serum progesterone levels correlate with decreased cerebral edema after traumatic brain injury in male rats. J Neurotrauma 18(9):901–909

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

The authors gratefully thank all the volunteers for their active interest and participation as a subject for recording ABR and also immensely thank Prof. Asim Das for his expert advice during the research. BPKIHS research committee grant.

Conflict of Interest

None.

Author information

Authors and Affiliations

  1. Department of Physiology, B.P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal

    Namrata Upadhayay, Bishnu Hari Paudel & Kopila Agrawal

  2. Department of Physiology, J.N. Medical College, A.M.U., Residence A-14, Medical Colony, Aligarh, 202002, India

    Paras Nath Singh

  3. Department of Anesthesiology & Critical Care, B.P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal

    Bal Krishna Bhattarai

Authors
  1. Namrata Upadhayay
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Bishnu Hari Paudel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Paras Nath Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bal Krishna Bhattarai
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kopila Agrawal
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Namrata Upadhayay.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Upadhayay, N., Paudel, B.H., Singh, P.N. et al. Pre- and Postovulatory Auditory Brainstem Response in Normal Women. Indian J Otolaryngol Head Neck Surg 66 (Suppl 1), 133–137 (2014). https://doi.org/10.1007/s12070-011-0378-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12070-011-0378-4

Keywords

Search

Navigation