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Comparison of Histopathological and CT Findings in Experimental Rabbit Sinusitis

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Abstract

The aim of this study was to investigate and compare histopathological and computerized tomographic (CT) findings of experimental acute sinusitis in an animal model. The noses of five healthy rabbits were inoculated with a gelatin sponge impregnated with a solution containing Staphylococcus aureus, and one healthy rabbit acted as the control. The animals were sacrificed on the tenth day, following the acquisition of paranasal CT scans. Specimens were obtained from the lateral nasal walls, and the ethmoid and maxillary sinuses of the animals for histopathological examination. Histopathological and CT findings were compared. Various degrees of epithelial disorganization, foci of ruptured epithelial cells, and inflammatory cell infiltration in the lamina propria were seen in the histopathological examinations of the five study rabbits, and mucosal thickening and soft tissue density were noted in their CTs. There was no correlation between the histopathological and CT findings. It was shown that CT did not reflect the acute changes in the sinus mucosa. Patients with chronic sinusitis must be evaluated for a chronic process. Computerized tomographic scans should not be obtained in acute sinusitis cases. In this way, both unnecessary radiation exposure and economic waste can be avoided.

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Authors and Affiliations

  1. 4. KBB Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey

    K. Murat Ozcan, Ibrahim Ozcan, Adin Selcuk, Ozgur Akdogan & Huseyin Dere

  2. Department of Histology and Embryology, Gazi University Medical Faculty, Ankara, Turkey

    Seren Gulsen Gurgen & Candan Ozogul

  3. 3. Radiology Clinic, Ankara Numune Education and Research Hospital, Ankara, Turkey

    Tagmac Deren & Suha Koparal

  4. Yucetepe sit A blok. 59/6 06580 Anittepe, Ankara, Turkey

    K. Murat Ozcan

Authors
  1. K. Murat Ozcan
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  2. Ibrahim Ozcan
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  3. Adin Selcuk
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  4. Ozgur Akdogan
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  5. Seren Gulsen Gurgen
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  6. Tagmac Deren
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  7. Suha Koparal
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  8. Candan Ozogul
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  9. Huseyin Dere
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Correspondence to K. Murat Ozcan.

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Ozcan, K.M., Ozcan, I., Selcuk, A. et al. Comparison of Histopathological and CT Findings in Experimental Rabbit Sinusitis. Indian J Otolaryngol Head Neck Surg 63, 56–59 (2011). https://doi.org/10.1007/s12070-011-0120-2

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  • DOI: https://doi.org/10.1007/s12070-011-0120-2

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