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Head and neck squamous cell cancer: Biology (1)

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Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

This review is the first section of tumor biology pertaining to head and neck squamous cell carcinoma (SCCHN). It is intended to introduce the basic concepts of cancer biology to enhance the translational research. The basic tumour biology relates to the aberrations in the normal cell cycle. cell growth and cell death. The genetic aspects of cancer focus upon the roles of oncogenes, tumor suppressor genes and stability genes. The epigenetic mechanisms of the cancer relates to DNA methylation and histone acetylation. This review, discusses the basics of these concepts.

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References

  1. Kinzler KW, Yogelstein B. Lesions from hereditary colorectal cancer. Cell 1996: 87:159–170.

    Article  PubMed  CAS  Google Scholar 

  2. Hernandez-Alcoceba R, del Peso L Lacal IE. The RAS family of GTPases in cancer cell invasion. Cellular and Molecular Life Sciences 2000; 57(1):65–76.

    Article  PubMed  CAS  Google Scholar 

  3. de Winter IP, vander Weel L, de Groot I, Stone S, Waistisz Q, Arwert F. The Fanconi anaemia protein F ANCF forms a nuclear complex with FANCA, FANCe. FANCG. Human Molecular Genetics 2000; 9(18):2665–2674.

    Article  PubMed  Google Scholar 

  4. Knudson AG. Heriditary cancer, oncogenes and anti oncogenes. Cancer Research 1985: 45:437–443.

    Google Scholar 

  5. Weinberg RA. Alteration of genomes of tumour cells. Cancer 1983; 51:1971–1975.

    Article  PubMed  CAS  Google Scholar 

  6. Boyd IA, Barrett IE. Genetic and cellular basis of multistep carcinogenesis. Pharmacology and Therapeutics. 1990; 46:469–486.

    Article  PubMed  CAS  Google Scholar 

  7. Yogelstein D, Kinzler KW. The multistep nature of cancer. Trends in Genetics 1993: 9:138–141.

    Article  Google Scholar 

  8. Hahn we Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA. Creation of human tumour cells with defined genetic elements. Nature 1999; 400:464–468.

    Article  Google Scholar 

  9. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100:57–70.

    Article  PubMed  CAS  Google Scholar 

  10. Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium, clinical implications of multicentric origin. Cancer 1953; 6(5):963–968.

    Article  PubMed  CAS  Google Scholar 

  11. AI-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification oftumorogenic breast cancer cells. Proc Natl Acad Sci USA 2003; 100:3983–3988.

    Article  Google Scholar 

  12. Momparler RL, Bovenzi V. DNA methylation and cancer. J Cell Physiol. 2000; 183: 145–154.

    Article  PubMed  CAS  Google Scholar 

  13. Herman JG. Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA. 1996: 93:9821–9826.

    Article  PubMed  CAS  Google Scholar 

  14. Hartwell LH, Szankasi P, Roberts CJ, Murray AW, Friend SF. Integrating genetic approaches into the discovery of anticancer drugs. Science 1997: 278:1064–1068.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Dept of Otolaryngology & HNS, King Gorge Medical University & GM Associated Hospital, Shahmeena Road, Lucknow, 226 003, India

    Anupam Mishra, Amita Pandey & Xiaolin Nong

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  1. Anupam Mishra
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  2. Amita Pandey
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  3. Xiaolin Nong
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Mishra, A., Pandey, A. & Nong, X. Head and neck squamous cell cancer: Biology (1). Indian J Otolaryngol Head Neck Surg 59, 28–32 (2007). https://doi.org/10.1007/s12070-007-0007-4

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  • DOI: https://doi.org/10.1007/s12070-007-0007-4

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