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Single-centre experience of transbronchial cryobiopsy as a first choice method for the diagnosis of interstitial lung disease

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Indian Journal of Thoracic and Cardiovascular Surgery Aims and scope Submit manuscript



The diagnosis of interstitial lung disease is based on clinical and biological analysis associated with computed tomography (CT) pattern after discussion in multidisciplinary discussion. Lung transbronchial cryobiopsy has emerged with acceptable diagnostic reliability and low morbidity and mortality. The goal of our work is to describe our experience with lung cryobiopsy.


This is monocentric and retrospective analysis of prospectively collected data on epidemiological, clinical, biological, CT, respiratory and histological features of patients with lung transbronchial cryobiopsy between January 1st, 2017, and July 1st, 2020.


Lung transbronchial cryobiopsy has been done for 23 patients with sex ratio M/F of 1.1, majority of smoker/former smoker. Thirty-nine percent of procedures were complicated by pneumothorax. On the haemorrhagic level, we reported 1 grade 2 bleeding (no serious bleeding). An histological diagnosis was obtained for 19 patients (82%). Only 4 patients needed to discuss surgical lung biopsy: 2 (8.6%) surgical lung biopsy, 1 refused surgical lung biopsy and 1 patient lost to follow-up.


Our results suggest that transbronchial lung cryobiopsy may be considered the first diagnostic modality instead of surgical lung biopsy for interstitial lung disease in appropriate patients. Larger studies are, however, needed to confirm our observations.

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Authors and Affiliations



Concept: FR

Data collection: FR, AC

Analysis: FR

Writer: FR

Critical review and approved: FR, AC, OB, HLF, WG, MAC, FC, JM, FG

All authors have read and approved this manuscript.

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Correspondence to Frédéric Rivière.

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Approval was granted from the protocol evaluation committee for observational research from the French Pneumologist Society (CEPRO 2018-035).

Human and animal rights statement

All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

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Rivière, F., Cazes, A., Bylicki, O. et al. Single-centre experience of transbronchial cryobiopsy as a first choice method for the diagnosis of interstitial lung disease. Indian J Thorac Cardiovasc Surg 38, 142–148 (2022).

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