Anterior mediastinal neurofibrosarcoma—a rare manifestation of neurofibromatosis type-1

  • Zubair Ahmad
  • Mohd Ilyas
  • Gh. Mohammad Wani
  • Sayar Ahmed Taley
  • Arif Ahmad Wani


Anterior mediastinal neurofibroma and neurofibrosarcoma form a rare class of tumors seen in patients of neurofibromatosis. We describe a case of anterior mediastinal neurofibrosarcoma in a known case of neurofibromatosis type-1.


Breathlessness Neurofibromatosis Neurofibrosarcoma 


Compliance with ethical standards

Ethical statement

No animals were used in the study.

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent was obtained from all individual participants included in the study.

Conflict of interests

The authors declare that they have no conflict of interest.


It is verified that all the authors had the access to the data and role in the writing of the manuscript.


  1. 1.
    Ferner RE, Gutmann DH. International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis. Cancer Res. 2002;62:1573–7.PubMedGoogle Scholar
  2. 2.
    Kalra B, Kingsley PA, Bedi HS, Kwatra KS, Negi P. Malignant peripheral nerve sheath tumor of the anterior mediastinum: a rare presentation. Rare Tumors. 2014;6:5528. CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Shimoyama T, Yoshiya K, Yamato Y, Koike T, Honma K. Long-term survival after removal of a malignant peripheral nerve sheath tumor originating in the anterior mediastinum. Gen Thorac Cardiovasc Surg. 2009;57:310–4.CrossRefPubMedGoogle Scholar
  4. 4.
    Richards JB, Marotti J, de Camp MM, et al. Thoracic malignant peripheral nerve sheath tumor a case report and literature review. Clinic Pulm Med. 2012;19:298–301.CrossRefGoogle Scholar

Copyright information

© Indian Association of Cardiovascular-Thoracic Surgeons 2018

Authors and Affiliations

  1. 1.Department of RadiodiagnosisSher-I-Kashmir Institute of Medical SciencesSrinagarIndia

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