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Coronary artery bypass grafting versus concomitant mitral valve annuloplasty in moderate ischemic mitral regurgitation: 4-year follow-up

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Abstract

Objective

In severe ischemic mitral regurgitation (IMR), there is benefit evidence for mitral valve repair with coronary artery bypass grafting (CABG). However, there is still a debate around combined repair and CABG for moderate IMR. We evaluate our results over 4-year follow-up for patients with moderate IMR who underwent isolated CABG and combined with mitral ring annuloplasty.

Methods

We retrospectively studied patients with moderate IMR; 69 patients underwent CABG alone group (A), and 77 patients underwent CABG with mitral valve ring annuloplasty group (B). New York Heart Association functional class (NYHA class), mitral regurgitation (MR) grade, and left ventricle (LV) dimension and ejection fraction (EF) were assessed preoperatively, 1 and 4 years postoperatively.

Results

The mortality rate was 2.9% in group (A) and 1.8% in group (B) p = 0.1593. Improvement in NYHA class, MR, and LVEF % were significant in both groups at 1 year with no significant changes at 4 years. However, group (B) showed significant improvement in LVEF % than group (A) at 4 years (47.5 ± 7.3 vs 44 ± 1.7, p ˂ 0.0001). It showed improvement in NYHA class at 1 and 4 years (1.5 ± 0.4 vs 2.1 ± 0.2) and (1 ± 0.2 vs 1.5 ± 0.5) p ˂ 0.0001, respectively. After 4 years, group (A) showed deterioration of MR degree in 4.3% of patients.

Conclusion

We strongly advise to add mitral valve ring annuloplasty with CABG for patients with moderate IMR.

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References

  1. Lamas GA, Mitchell GF, Flaker GC, et al. Clinical significance of mitral regurgitation after acute myocardial infarction. Survival and Ventricular Enlargement Investigators. Circulation. 1997;96:827–33.

    Article  CAS  PubMed  Google Scholar 

  2. Grigioni F, Enriquez-Sarano M, Zehr KJ, Bailey KR, Tajik AJ. Ischemic mitral regurgitation: long-term outcome and prognostic implications with quantitative Doppler assessment. Circulation. 2001;103:1759–64.

    Article  CAS  PubMed  Google Scholar 

  3. Enriquez-Sarano M, Schaff HV, Frye RL. Mitral regurgitation: what causes the leakage is fundamental to the outcome of valve repair. Circulation. 2003;108:253–6.

    Article  PubMed  Google Scholar 

  4. Di Mauro M, Di Giammarco G, Vitolla G, et al. Impact of no-to-moderate mitral regurgitation on late results after isolated coronary artery bypass grafting in patients with ischemic cardiomyopathy. Ann Thorac. 2006;81:2128–34.

    Article  Google Scholar 

  5. Aklog L, Filsoufi F, Flores KQ, et al. Does coronary artery bypass grafting alone correct moderate ischemic mitral regurgitation? Circulation. 2001;104:I68–75.

    Article  CAS  PubMed  Google Scholar 

  6. Lam BK, Gillinov AM, Blackstone EH, et al. Importance of moderate ischemic mitral regurgitation. Ann Thorac Surg. 2005;79:462–70.

    Article  PubMed  Google Scholar 

  7. Ryden T, Bech-Hanssen O, Brandrup-Wognsen G, Nilsson F, Svensson S, Jeppsson A. The importance of grade 2 ischemic mitral regurgitation in coronary artery bypass grafting. Eur J Cardiothorac Surg. 2001;20:276–81.

    Article  CAS  PubMed  Google Scholar 

  8. Campwala SZ, Bansal RC, Wang N, Razzouk A, Pai RG. Mitral regurgitation progression following isolated coronary artery bypass surgery: frequency, risk factors, and potential prevention strategies. Eur J Cardiothorac Surg. 2006;29:348–53.

    Article  PubMed  Google Scholar 

  9. Nishimura RA, Otto CM, Bonow RO, et al. AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129:2440–92.

    Article  PubMed  Google Scholar 

  10. Czer LS, Maurer G, Trento A, et al. Comparative efficacy of ring and suture annuloplasty for ischemic mitral regurgitation. Circulation. 1992;86:II46–52.

    CAS  PubMed  Google Scholar 

  11. Czer LS, Maurer G, Bolger AF, DeRobertis M, Chaux A, Matloff JM. Revascularization alone or combined with suture annuloplasty for ischemic mitral regurgitation. Evaluation by color Doppler echocardiography. Tex Heart Inst J. 1996;23:270–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  12. El Oakley RM, Wright JE. Postoperative mediastinitis: classification and management. Ann Thorac Surg. 1996;61:1030–6.

    Article  PubMed  Google Scholar 

  13. Maisel WH, Rawn JD, Stevenson WG. Atrial fibrillation after cardiac surgery. Ann Intern Med. 2001;135:1061–73.

    Article  CAS  PubMed  Google Scholar 

  14. Tcheng JE, Jackman Jr JD, Nelson CL, et al. Outcome of patients sustaining acute ischemic mitral regurgitation during myocardial infarction. Ann Intern Med. 1992;117:18–24.

    Article  CAS  PubMed  Google Scholar 

  15. Frantz E, Weininger F, Oswald H, Fleck E. Predictors for mitral regurgitation in coronary artery disease. In: Vetter HO, Hetzer R, Schmutzler H, editors. Ischemic mitral incompetence. New York: Springer-Verlag; 1991. p. 57–73.

    Chapter  Google Scholar 

  16. Vahanian A, Alfieri O, Andreotti F, et al. The Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology and the European Association for Cardio-Thoracic Surgery. Guidelines on the management of valvular heart disease (version 2012). Eur Heart J. 2012;33:2451–96.

    Article  PubMed  Google Scholar 

  17. Years 2008–2012: the Adult Cardiac Surgery Database. Chicago: Society of Thoracic Surgeons (http://www.sts.org/national-database).

  18. Acker MA, Parides MK, Perrault LP, et al. Mitral-Valve Repair versus Replacement for Severe Ischemic Mitral Regurgitation. N Engl J Med. 2014;370:23–32.

    Article  CAS  PubMed  Google Scholar 

  19. Foster E, Kwan D, Feldman T, et al. Percutaneous mitral valve repair in the initial EVEREST cohort: evidence of reverse left ventricular remodeling. Circ Cardiovasc Imaging. 2013;6:522–30.

    Article  PubMed  Google Scholar 

  20. Penicka M, Linkova H, Lang O, et al. Predictors of improvement of unrepaired moderate ischemic mitral regurgitation in patients undergoing elective isolated coronary artery bypass graft surgery. Circulation. 2009;120:1474–81.

    Article  PubMed  Google Scholar 

  21. Kang DH, Kim MJ, Kang SJ, et al. Mitral valve repair versus revascularization alone in the treatment of ischemic mitral regurgitation. Circulation. 2006;114:I499–503.

    Article  PubMed  Google Scholar 

  22. Chan KM, Punjabi PP, Flather M, et al. Coronary artery bypasses surgery with or without mitral mitral valve annuloplasty in moderate functional ischemic mitral regurgitation: final results of the Randomized ischemic mitral Evaluation (RIME) trial. Circulation. 2012;126:2502–10.

    Article  PubMed  Google Scholar 

  23. Vaskelyte J, Stoskute N, Ereminiene E, Zaliunas R, Benetis R, Sirvinskas E. The impact of unrepaired versus repaired mitral regurgitation on functional status of patients with ischemic cardiomyopathy at one year after coronary artery bypass grafting. J Heart Valve Dis. 2006;15:747–54.

    PubMed  Google Scholar 

  24. Smith PK, Puskas JD, Ascheim DD, et al. Surgical treatment of moderate ischemic mitral regurgitation. N Engl J Med. 2014;371:2178–88.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Yin L, Wang Z, Shen H, Min J, Ling X, Xi W. Coronary artery bypass grafting versus combined coronary artery bypass grafting and mitral valve repair interacting ischemic mitral regurgitation: a meta analysis. Heart Lung Circ. 2014;23:905–12.

    Article  PubMed  Google Scholar 

  26. Michler RE, Smith PK, Parides MK, et al. Two-Year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation. N Engl J Med. 2016;374:1932–41.

    Article  CAS  PubMed  Google Scholar 

  27. Miller DC. Ischemic mitral regurgitation redux–to repair or to replace? J Thorac Cardiovasc Surg. 2001;122:1059–62.

    Article  CAS  PubMed  Google Scholar 

  28. Levine RA, Schwammenthal E. Ischemic mitral regurgitation on the threshold of a solution: from paradoxes to unifying concepts. Circulation. 2005;112:745–58.

    Article  PubMed  Google Scholar 

  29. Mihaljevic T, Lam BK, Rajeswaran J, et al. Impact of mitral valve annuloplasty combined with revascularization in patients with functional ischemic mitral regurgitation. J Am Coll Cardiol. 2007;49:2191–201.

    Article  PubMed  Google Scholar 

  30. Serri K, Bouchard D, Demers P, et al. Is a good perioperative echocardiographic result predictive of durability in ischemic mitral valve repair? J Thorac Cardiovasc Surg. 2006;131:565–73.e2.

    Article  CAS  PubMed  Google Scholar 

  31. Fattouch K, Guccione F, Sampognaro R, et al. POINT: Efficacy of adding mitral valve restrictive annuloplasty to coronary artery bypass grafting in patients with modrate ischemic mitral valve regurgitation. Jthorac Cardiovasc Surg. 2009;138:278–85.

    Article  Google Scholar 

  32. Schurr P, Boeker U, Linathe J, Akhyari P, Feindt P, Lichtenberg A. Impact of mitral valve repair in patients with mitral regurgitation undergoing coronary artery bypass grafting. Acta Cardiol. 2010;65:441–7.

    PubMed  Google Scholar 

  33. Dimauro M, Pigiammarco G, Vitolla G, et al. Impact of no-to moderate mitral regurgitation on late results after isolated coronary artery bypass grafting in patients with ischemic cardiomyopathy. Ann Thorac Surg. 2006;81:2128–34.

    Article  Google Scholar 

  34. Kopjar T, Gasparovic H, Mestres CA, Milicic D, Biocina B. Meta-analysis of concomitant mitral valve repair and coronary artery bypass surgery versus isolated coronary artery bypass surgery in patients with moderate ischemic mitral regurgitation. Eur J Cardiothorac Surg. 2016;50:212–22.

    Article  PubMed  Google Scholar 

  35. Kim YH, Czer LS, Soukiasian HJ, et al. Ischemic mitral regurgitation: revascularization alone versus revascularization and mitral valve repair. Ann Thorac Surg. 2005;79:1895–901.

    Article  PubMed  Google Scholar 

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Correspondence to Hanan Ibrahim Radwan.

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Hamouda, T.H., Ismail, M.F., El-Mahrouk, A.F. et al. Coronary artery bypass grafting versus concomitant mitral valve annuloplasty in moderate ischemic mitral regurgitation: 4-year follow-up. Indian J Thorac Cardiovasc Surg 33, 1–8 (2017). https://doi.org/10.1007/s12055-016-0472-z

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  • DOI: https://doi.org/10.1007/s12055-016-0472-z

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