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Enhanced U-Net-based segmentation and heuristically improved deep neural network for pulmonary emphysema diagnosis

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Abstract

Pulmonary emphysema is a main part of chronic obstructive pulmonary disease and lung cancer. Though, quantitative emphysema severity prediction is essential in patients with unclear lung cancer categories. Thus, diagnosis of pulmonary emphysema at the early stage is more significant and could save human life. Moreover, non-invasive positive pressure ventilation is a life-saving method that focuses on reducing the complexities in patients. When failure occurs in non-invasive positive pressure ventilation, there are more chances for mortality, which shows the significance of rational diagnosis. The delay in endotracheal intubation is avoided by developing different approaches, which leads to more demand. This paper plans to develop an enhanced system for pulmonary emphysema diagnosis using deep learning-based segmentation and classification. Initially, the detection model considers pre-processing with the help of Contrast Limited Adaptive Histogram Equalization (CLAHE) and average filtering. Moreover, lung segmentation is the major part of pulmonary emphysema diagnosis. Here, the enhanced U-Net model is utilized for lung segmentation by considering the multi-objective function with the developed algorithm. Then, the feature extraction is done using the local tri-directional weber pattern and local directional pattern descriptors. The extracted features are classified by the heuristically improved deep neural network based on a new algorithm, which will optimally diagnose the severity of pulmonary emphysema. Both segmentation and classification will be enhanced by proposing a new Electric Fish-based Grey Wolf Optimization (EF-GWO). Here, various performance metrics, like accuracy, precision, specificity, etc., on the public dataset by comparing with other models. The accuracy of the EF-GWO with E-UNet is 96%. The accuracy of the suggested developed EF-GWO based on HI-DNN is 97%. Hence, it verifies the superior performance of the recommended pulmonary emphysema disease diagnosis method with improved segmentation and classification techniques compared to other existing methods.

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References

  1. Guo H-M, Du J and Huang L 2017 Application of model based on R language in predicting incidence of patients with acute exacerbation of chronic obstructive pulmonary disease, (in Chinese). Health Stat. 34(2): 288–289

    Google Scholar 

  2. Hakim M A, Garden F L, Jennings M D and Dobler C C 2017 Performance of the LACE index to predict 30-day hospital readmissions in patients with chronic obstructive pulmonary disease. Clin. Epidemiol. 10: 51

    Article  Google Scholar 

  3. Himes B E, Dai Y, Kohane I S, Weiss S T and Ramoni M F 2016 Prediction of chronic obstructive pulmonary disease (COPD) in asthma patients using electronic medical records. J. Am. Med. Inform. Assoc. 16(3): 371–379

    Article  Google Scholar 

  4. Lu G, Li D and Zhang L 2013 Clinical investigation of depression in elderly patients with chronic obstructive pulmonary disease. China Med. Pharmacy 3(1): 12–14

    Google Scholar 

  5. Sanchez-Morillo D, Fernandez-Granero M A and Leon-Jimenez A 2016 Use of predictive algorithms in-home monitoring of chronic obstructive pulmonary disease and asthma: A systematic review. Chronic Respir. Dis. 13(3): 264–283

    Article  Google Scholar 

  6. Danielsson P, Ólafsdóttir I S, Benediktsdóttir B, Gíslason T and Janson C 2012 The prevalence of chronic obstructive pulmonary disease in Uppsala, Sweden-The burden of obstructive lung disease (BOLD) study: Cross-sectional population-based study. Clin. Respir. J. 6(2): 120–127

    Article  Google Scholar 

  7. Borné Y, Ashraf W, Zaigham S and Frantz S 2019 Socioeconomic circumstances and incidence of chronic obstructive pulmonary disease (COPD) in an urban population in Sweden, COPD. J. Chronic Obstr. Pulm. Dis. 16(1): 51–57

    Article  Google Scholar 

  8. Jensen M H, Cichosz S L, Dinesen B and Hejlesen O K 2012 Moving prediction of exacerbation in chronic obstructive pulmonary disease for patients in telecare’. J. Telemed. Telecare 18(2): 99–103

    Article  Google Scholar 

  9. Burton C, Pinnock H and McKinstry B 2015 Changes in telemonitored physiological variables and symptoms prior to exacerbations of chronic obstructive pulmonary disease. J. Telemed. Telecare 21(1): 29–36

    Article  Google Scholar 

  10. Ohayon M M 2014 Chronic obstructive pulmonary disease and its association with sleep and mental disorders in the general population. J. Psychiatric Res. 54: 79–84

    Article  Google Scholar 

  11. Zhu Y and Zhang W 2015 Discussion on the treatment of chronic obstructive pulmonary disease from lung, spleen, and kidney. Shanxi J. Tradit. Chin. Med. 31(7): 1–2

    Google Scholar 

  12. Zhong N and Cai C 2006 Relationship between chronic obstructive pulmonary disease and anxiety depression’. Cont. Med. Educ. 21(16): 17–19

    Google Scholar 

  13. Tee A 2017 Chronic obstructive pulmonary disease (COPD): Not a cigarette only pulmonary disease. Ann. Acad. Med. 46(11): 415–416

    MathSciNet  Google Scholar 

  14. Dranseld M T, Kunisaki K M, Strand M J, Anzueto A, Bhatt S P, Bowler R P, Criner G J, Curtis J L, Hanania N A and Nath H 2017 Acute exacerbations and lung function loss in smokers with and without chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 195(3): 324–330

    Article  Google Scholar 

  15. Obi J, Mehari A and Gillum R 2018 Mortality related to chronic obstructive pulmonary disease and co-morbidities in the United States, a multiple causes of death analysis, COPD. J. Chronic Obstr. Pulm. Dis. 15(2): 200–205

    Article  Google Scholar 

  16. Raju B M, Jotkar S, Prathyusha M, Goswami S, Dube M and Singh A 2018 Effectiveness of non-invasive positive pressure ventilation for acute exacerbation of chronic obstructive pulmonary disease. Int. J. 5(2): 102

    Google Scholar 

  17. Köhnlein T, Windisch W, Köhler D, Drabik A, Geiseler J, Hartl S, Karg O, Laier-Groeneveld G, Nava S and Schönhofer B 2014 Noninvasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: A prospective, multicentre, randomised, controlled clinical trial. Lancet Respir. Med. 2(9): 698–705

    Article  Google Scholar 

  18. Meinel F G, Schwab F, Schleede S, Bech M, Herzen J, Achterhold K, Auweter S, Bamberg F, Yildirim A Ö, Bohla A, Eickelberg O, Loewen R, Gifford M, Ruth R, Reiser M F, Pfeiffer F, Nikolaou K 2013. Diagnosing and Mapping Pulmonary Emphysema on X-Ray Projection Images: Incremental Value of Grating-Based X-Ray Dark-Field Imaging", PLOS ONE, 8(3)

  19. Chan K-S, Jiao F, Mikulski M A, Gerke A, Guo J, Newell J D, Hoffman E A, Thompson B, Lee C H and Fuortes L J 2016 Novel Logistic Regression Model of Chest CT Attenuation Coefficient Distributions for the Automated Detection of Abnormal (Emphysema or ILD) Versus Normal Lung. Academic Radiology 23(3): 304–314

    Article  Google Scholar 

  20. Fang Y, Wang H, Wang L, Di R and Song Y 2019 Diagnosis of COPD Based on a Knowledge Graph and Integrated Model. IEEE Access 7: 46004–46013

    Article  Google Scholar 

  21. Lee S J, Yoo J W, Ju S, Cho Y J, Kim J D, Kim S H, Jang I‐S, Jeong B K, Lee G‐W, Jeong Y Y, Kim H C, Bae K, Jeon K N, Lee J D 2018. Quantitative severity of pulmonary emphysema as a prognostic factor for recurrence in patients with surgically resected non‐small cell lung cancer, Thoracic cancer 10(3): 421–427

  22. Boer E, Nijholt I M, Jansen S, Edens M A, Walen S, Berg J W K and Boomsma M F 2019. Optimization of pulmonary emphysema quantification on CT scans of COPD patients using hybrid iterative and post processing techniques: correlation with pulmonary function tests, Insights into Imaging, 10

  23. Weng Yang, Fang Yin, Yan Haiying, Yang Yang and Hong Wenxing 2019 Bayesian Non-Parametric Classification With Tree-Based Feature Transformation for NIPPV Efficacy Prediction in COPD Patients. IEEE Access 7: 177774–177783

    Article  Google Scholar 

  24. Isaac A, Nehemiah H K, Isaac A and Kannan A 2020. Computer-Aided Diagnosis system for diagnosis of pulmonary emphysema using bio-inspired algorithms, Computers in Biology and Medicine, 124

  25. Wang Q, Wang H, Wang L and Yu F 2020 Diagnosis of Chronic Obstructive Pulmonary Disease Based on Transfer Learning. IEEE Access 8: 47370–47383

    Article  Google Scholar 

  26. Ma J, Fan X, Yang S X, Zhang X and Zhu X 2017. Contrast Limited Adaptive Histogram Equalization Based Fusion for Underwater Image Enhancement, International Journal of Pattern Recognition and Artificial Intelligence, 32(07)

  27. Qu J, Li Y and Dong W 2018 Fusion of hyperspectral and panchromatic images using an average filter and a guided filter. Journal of Visual Communication and Image Representation 52: 151–158

    Article  Google Scholar 

  28. Hambarde P, Talbar S, Mahajan A, Chavan S, Thakur M and Sable N 2020 Prostate lesion segmentation in MR images using radiomics based deeply supervised U-Net. Biocybernetics and Biomedical Engineering 40(4): 1421–1435.

    Article  Google Scholar 

  29. Jabid T, Kabir H and Chae O 2010. Local Directional Pattern (LDP)—A Robust Image Descriptor for Object Recognition, Advanced Video and Signal Based Surveillance.

  30. Gangavarapu V S K and Pillutla G K M 2016 Local Tri-directional Weber Patterns: A New Descriptor for Texture and Face Image Retrieval. International Journal of Computer Science and Information Technologies 7(3): 1571–1577

    Google Scholar 

  31. Yilmaz S and Sen S 2020 Electric fish optimization: a new heuristic algorithm inspired by electrolocation. Neural Computing and Applications 32: 11543–11578

    Article  Google Scholar 

  32. Mirjalili S, Mirjalili S M and Lewis A 2014 Grey Wolf Optimizer. Advances in Engineering Software 69: 46–61

    Article  Google Scholar 

  33. Beno M M, Valarmathi I R, Swamy S M and Rajakumar B R 2014 Threshold prediction for segmenting tumour from brain MRI scans. International Journal of Imaging Systems and Technology 24(2): 129–137

    Article  Google Scholar 

  34. Ramesh S and Vydeki D 2020 Recognition and classification of paddy leaf diseases using Optimized Deep Neural network with Jaya algorithm. Information Processing in Agriculture 7(2): 249–260

    Article  Google Scholar 

  35. Bonyadi M R and Michalewicz Z 2016 Analysis of Stability, Local Convergence, and Transformation Sensitivity of a Variant of the Particle Swarm Optimization Algorithm. IEEE Transactions on Evolutionary Computation 20(3): 370–385

    Article  Google Scholar 

  36. Wang T, Yang L and Liu Q 2018. Beetle Swarm Optimization Algorithm: Theory and Application, Neural and Evolutionary Computing

  37. Tsang S, Kao B, Yip K Y, Ho W and Lee S D 2011 Decision Trees for Uncertain Data. IEEE Transactions on Knowledge and Data Engineering 23(1): 64–78

    Article  Google Scholar 

  38. Wu J and Yang H 2015 Linear Regression-Based Efficient SVM Learning for Large-Scale Classification. IEEE Transactions on Neural Networks and Learning Systems 26(10): 2357–2369

    Article  MathSciNet  Google Scholar 

  39. Wu D, Pigou L, Kindermans P-J, Le ND-H, Shao L, Dambre J and Odobez J-M 2016 Deep Dynamic Neural Networks for Multimodal Gesture Segmentation and Recognition. IEEE Transactions on Pattern Analysis and Machine Intelligence 38(8): 1583–1597.

    Article  Google Scholar 

  40. Dehmeshki J, Amin H, Valdivieso M and Ye X 2008 Segmentation of Pulmonary Nodules in Thoracic CT Scans: A Region Growing Approach. IEEE Transactions on Medical Imaging 27(4): 467–480

    Article  Google Scholar 

  41. Li B N, Qin J, Wang R, Wang M and Li X 2016 Selective Level Set Segmentation Using Fuzzy Region Competition. IEEE Access 4: 4777–4788

    Article  Google Scholar 

  42. Tareef A, Song Y, Huang H, Feng D, Chen M, Wang Y and Cai W 2018 Multi-Pass Fast Watershed for Accurate Segmentation of Overlapping Cervical Cells. IEEE Transactions on Medical Imaging 37(9): 2044–2059.

    Article  Google Scholar 

  43. Kalavathi P 2013. Brain tissue segmentation in MR brain images using multiple Otsu's thresholding technique, Computer Science & Education: 639-642

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Correspondence to K Ananthajothi.

Abbreviations

Abbreviations

BSO:

Beetle Swarm Optimization

BDP:

Balanced Probability Distribution

CLAHE:

Contrast Limited Adaptive Histogram Equalization

EF-GWO:

Electric Fish-based Grey Wolf Optimization

CT:

Computed Tomography

E-UNet:

Enhanced U-Net

DNN:

Deep Neural Network

COPD:

Chronic Obstructive Pulmonary Disease

MCC:

Mathews Correlation Coefficient

HI-DNN:

Heuristically Improved Deep Neural Network

ReLU:

Rectified Linear Unit

NIPPV:

Non-Invasive Positive Pressure Ventilation

SVM:

Support Vector Machine

GWO:

Grey Wolf Optimization

SPECT:

Single-Photon Emission Computed Tomography

FDR:

False Discovery Rate

LTriWP:

Local Tri-directional Weber Pattern

ISP:

IntelliSpace Portal

NPV:

Negative Predictive Value

CAD:

Computer-Aided Diagnosis

DT:

Decision Trees

EFO:

Electric Fish Optimization

FNR:

False Negative Rate

LDP:

Local Directional Pattern

NN:

Neural Networks

PSO:

Particle Swarm Optimization

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Ananthajothi, K., Rajasekar, P. & Amanullah, M. Enhanced U-Net-based segmentation and heuristically improved deep neural network for pulmonary emphysema diagnosis. Sādhanā 48, 33 (2023). https://doi.org/10.1007/s12046-023-02092-5

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  • DOI: https://doi.org/10.1007/s12046-023-02092-5

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