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PI controller scheme for charge balance in implantable electrical stimulators

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Abstract

Electrical stimulation has been used in a wide variety of medical implant applications. In all of these applications, due to safety concerns, maintaining charge balance becomes a critically important issue that needs to be addressed at the design stage. It is important that charge balancing schemes be robust to circuit (process) and load impedance variations, and at the same time must also lend themselves to miniaturization. In this communication, simulation studies on the effectiveness of using Proportional Integral (P-I) control schemes for managing charge balance in electrical stimulation are presented. The adaptation of the P-I control scheme to implant circuits leads to two possible circuit realizations in the analog domain. The governing equations for these realizations are approximated to simple linear equations. Considering typical circuit and tissue parameter values and their expected uncertainties, Matlab as well as circuit simulations have been carried out. Simulation results presented indicate that the tissue voltages settle to well below 20% of the safe levels and within about 20 stimulations cycles, thus confirming the validity and robustness of the proposed schemes.

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References

  1. Sit J J and Sarpeshkar R 2007 A low-power blocking-capacitor-free charge-balanced electrode-stimulator chip with less than 6 nA DC error for 1-mA full-scale stimulation. IEEE Trans. Biomed. Circuits Syst. 1(3): 172–183, doi: 10.1109/TBCAS.2007.911631

    Article  Google Scholar 

  2. Sooksood K, Stieglitz T and Ortmanns M 2010 An active approach for charge balancing in functional electrical stimulation. IEEE Trans. Biomed. Circuits Syst. 4(3): 162–170, doi: 10.1109/TBCAS.2010.2040277

    Article  Google Scholar 

  3. Jiang D, Demosthenous A, Perkins T, Liu X and Donaldson N 2011 A stimulator ASIC featuring versatile management for vestibular prostheses. Biomed. Circuits Syst. IEEE Trans. 5(2): 147–159 doi: 10.1109/TBCAS.2011.2138139

    Article  Google Scholar 

  4. Li Y T, Chen J J, Chen L T, Lin W S, Chu C H 2012 Wireless implantable biomicrosystem for bladder pressure monitoring and nerve stimulation. In: Biomedical circuits and systems conference (BioCAS), 2012 IEEE, pp 296–299, doi: 10.1109/BioCAS.2012.6418438

  5. Cogan S F 2008 Neural stimulation and recording electrodes. Ann. Rev. Biomed. Eng. 10 (1): 275–309, doi: 10.1146/annurev.bioeng.10.061807.160518, pMID: 18429704

  6. Sooksood K, Stieglitz T and Ortmanns M 2009 An experimental study on passive charge balancing. Adv. Radio Sci. 7 (15): 197–200

    Article  Google Scholar 

  7. Lee E K F, Lam A 2007 A matching technique for biphasic stimulation pulse. IEEE international symposium on circuits and systems, pp 817–820, doi: 10.1109/ISCAS.2007.378031

  8. Fang X, Wills J, Granacki J, LaCoss J, Choma J 2008 CMOS charge-metering microstimulator for implantable prosthetic device. MWSCAS 2008 51st Midwest symposium on circuits and systems, pp 826–829, doi: 10.1109/MWSCAS.2008.4616927

  9. Ortmanns M, Rocke A, Gehrke M and Tiedtke H 2007 A 232-channel epiretinal stimulator ASIC. IEEE J. Solid-State Circuits 42(12): 2946–2959, doi: 10.1109/JSSC.2007.908693

    Article  Google Scholar 

  10. Zheng L, Shin S, Kang S 2012 Design of a neural stimulator system with closed-loop charge cancellation. In: VLSI and System-on-Chip (VLSI-SoC), 2012 IEEE/IFIP 20th international conference on, IEEE, pp 1–6

  11. Lo Y K, Hill R, Chen K, Liu W 2013 Precision control of pulse widths for charge balancing in functional electrical stimulation. In: (NER) 6 th international IEEE/EMBS conference on neural engineering, pp 1481–1484, doi: 10.1109/NER.2013.6696225

  12. Chu J U, Song K I, Shon A, Han S, Lee S H, Kang J Y, Hwang D, Suh J K F, Choi K and Youn I 2013 Feedback control of electrode offset voltage during functional electrical stimulation. J. Neurosci. Methods 218 (1): 55–71, doi: 10.1016/j.jneumeth.2013.05.003, http://www.sciencedirect.com/science/article/pii/S0165027013001775

  13. Zeng F G, Rebscher S, Harrison W, Sun X and Feng H 2008 Cochlear implants: System design, integration, and evaluation. IEEE Rev. Biomed. Eng. 1: 115–142 doi: 10.1109/RBME.2008.2008250

    Article  Google Scholar 

  14. Jiang D, Demosthenous A, Cirmirakis D, Perkins T, Donaldson N 2010 Design of a stimulator asic for an implantable vestibular neural prosthesis. In: Biomedical circuits and systems conference (BioCAS), 2010 IEEE, pp 206–209, doi: 10.1109/BIOCAS.2010.5709607

  15. Guo S, Lee H, Loizou P 2008 A 9-bit configurable current source with enhanced output resistance for cochlear stimulators. In: Custom integrated circuits conference, 2008. CICC 2008. IEEE, pp 511–514, doi: 10.1109/CICC.2008.4672134

  16. Noorsal E, Sooksood K, Xu H, Hornig R, Becker J and Ortmanns M 2012 A neural stimulator frontend with high-voltage compliance and programmable pulse shape for epiretinal implants. IEEE J. Solid-State Circuits 47(1): 244–256, doi: 10.1109/JSSC.2011.2164667

    Article  Google Scholar 

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Acknowledgements

The author would like to thank Dr. P.V. Ramakrishna, Department of ECE, College of Engineering, Guindy for his guidance at various stages and insightful comments that greatly helped to improve on the results.

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RATHNA, C. PI controller scheme for charge balance in implantable electrical stimulators. Sadhana 41, 31–45 (2016). https://doi.org/10.1007/s12046-016-0461-3

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