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100 Years of Haldane’s Rule

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J.B.S Haldane, a polymath with extraordinary intellectual qualities, contributed significantly to 20th-century biology, especially to evolutionary theory and genetics. Among his major contributions is a generalisation that has come to be called ‘Haldane’s Rule’. It states that among the offspring born to parents from two different animal races, if one of the sexes is absent, rare, or sterile, that sex is characterised by unlike sex chromosomes. Haldane’s rule remains an unusual example of something like a law of nature in biology and thus continues to attract attention and debate. We discuss some of the more interesting attempts to explain why the rule works.

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This article is based on our talk presented at the mini-symposium on “100 years of Haldane’s rule” organised at the Centre for Human Genetics We would like to thank and express our gratitude to Prof. Vidyanand Nanjundiah, Centre for Human Genetics, for his suggestions and comments.

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Correspondence to Apeksha Arun Bhandarkar or Akshatha E. Nagarkatte.

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Apeksha Arun Bhandarkar has completed her Masters in Human Disease Genetics from Centre for Human Genetics, Bengaluru. Her areas of interests include Reproductive Health, Human diseases, Prenatal genetics and Cancer genetics. She wants to pursue a PhD and contribute extensively in the area through research and make a noticeable impact.

Akshatha E Nagarkatte has completed her MSc in Human Disease Genetics from Centre for Human Genetics. Her areas of interest include cancer biology, epigenetics, and cytogenetics. She aspires to pursue PhD in the field of cancer biology with an aim to contribute to the betterment of cancer treatment strategies.

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Bhandarkar, A.A., Nagarkatte, A.E. 100 Years of Haldane’s Rule. Reson 28, 959–973 (2023).

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