Abstract
D-Glucose, in its normal form, is known to most of us. Interestingly, just by replacing an -OH group with a hydrogen, we get 2-deoxy-D-glucose (2-DG) which has excellent medicinal properties. An interesting observation related to glycolysis led to the use of 2-DG as an anticancer drug. Recently, there has been sufficient evidence to support the efficacy of 2-DG as an anti-Covid medication.
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B G Davis and A J Fairbanks, Carbohydrate Chemistry, Oxford University Press, New York, p.7, First published 2002.
H G Garg, M K Cowman and C A Hales, Carbohydrate Chemistry, Biology and Medical Applications, Elsevier Science, p.2, Year: 2008.
O Warburg, On the origin of cancer cells, Science, Vol.123, pp.309–314, 1956.
H Pelicano, D S Martin, R H Xu and P Huang, Glycolysis inhibition for anticancer treatment, Oncogene, Vol.25, pp.4633–4646, 2006.
J Brown, Effects of 2-deoxyglucose on carbohydrate metablism: Review of the literature and studies in the rat, Metabolism, Vol.11, pp.1098–1112, 1962.
R Weindruch, K P Keenan, J M Carney, G Fernandes, R J Feuers, R A Floyd, J B Halter, J J Ramsey, A Richardson, G S Roth and S R Spindler, Caloric restriction mimetics: Metabolic interventions, J Gerontol A Biol Sci Med Sci., Vol.56, pp.20–33, 2001.
J C Maher, A Krishan and T J Lampidis, Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-D-glucose in tumor cells treated under hypoxic vs aerobic conditions, Cancer Chemother Pharmacol, Vol.53, pp.116–122, 2004.
D Singh, A K Banerji, B S Dwarakanath, R P Tripathi, J P Gupta, T L Mathew, T Ravindranath and V Jain, Optimizing cancer radiotherapy with 2-deoxy-D-glucose dose escalation studies in patients with glioblastoma multiforme, Strahlenther Onkol, Vol.181, pp.507–514, 2005.
“DCGI approves anti-COVID drug developed by DRDO for emergency use”, Press Information Bureau, Government of India, 2021-05-08.
J Koshy, “Questions remain on DRDO’s COVID) drug”, The Hindu, Date-2021-05-11.
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Arnab Chatterjee completed his post-graduation in chemistry from The University of Burdwan in 2014 and joined the group of R. Ghosh for his doctoral research. He received his PhD in chemistry last year.
Rajarshi Ghosh is associated with post graduation teaching and research in the Department of Chemistry, The University of Burdwan. His research interest covers synthetic coordination chemistry, bio inspired catalysis, biological inorganic chemistry, etc. Besides these, he is also interested in science popularization.
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Chatterjee, A., Ghosh, R. 2-Deoxy-D-Glucose. Reson 27, 1737–1740 (2022). https://doi.org/10.1007/s12045-022-1468-1
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DOI: https://doi.org/10.1007/s12045-022-1468-1