Skip to main content
SpringerLink
Log in

Safe and Green A Convenient Laboratory Preparation of Acetanilide*

  • Classroom
  • Published:
Resonance Aims and scope Submit manuscript

Abstract

Preparation of acetanilide by the acetylation of aniline is an important exercise in organic synthesis at the undergraduate level. It involves treating aniline with an acetylating agent in the presence of an acid, base, or reducing agent and very often requires heating. Here, we report a safe and green procedure for this synthesis. This method is not only very convenient but also gives an excellent yield of acetanilide.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Suggested Reading

  1. F G Mann and B C Saunders, Practical Organic Chemistry, Longman Inc, New York, Fourth Edition, p.108, 365, 1978.

    Google Scholar 

  2. A I Vogel, A Textbook of Practical Organic Chemistry, Longman Group Ltd, London, pp.577–578, 1975.

    Google Scholar 

  3. Monograph on Green Chemistry Laboratory Experiments, edited and published by Green Chemistry Task Force Committee, DST, India, p.11, 2011.

    Google Scholar 

  4. S Ouarna et al., An eco-friendly and highly efficient route for N-acylation under catalyst-free conditions, Orient J Chem., Vol.31, No.2, pp.913–919, 2015.

    Article  Google Scholar 

  5. G Brahmachari, S Laskar and S Sarkar, A green approach to chemoselective N-acetylation of amines using catalytic amount of zinc acetate in acetic acid under microwave irradiation, Indian J. Chem., V61.49B, pp.1274–1281, 2010.

    Google Scholar 

  6. Sangeeta Pandita, Samta Goyal, Nadira Arif and Sarita Passey, A simple test to distinguish between D-glucose and D-fructose, Resonance, Vol.12, No.4, p.92, 2007.

    Article  Google Scholar 

  7. Sangeeta Pandita and Sarita Passey, Distinguishing between monosaccharides and disaccharides, Resonance, Vol.15, No.12, pp.1122–1126, 2010.

    Article  Google Scholar 

  8. Sangeeta Pandita and Sarita Passey, A safe procedure for bromination of acetanilide, Resonance, Vol.18, No.3, pp.282–284, 2013.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Zakir Husain Delhi College, J L Nehru Marg, New Delhi, 110 002, India

    Sarita Passey

Authors
  1. Sarita Passey
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Krishan Kumar Arora
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sarita Passey.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Passey, S., Arora, K.K. Safe and Green A Convenient Laboratory Preparation of Acetanilide*. Reson 27, 455–458 (2022). https://doi.org/10.1007/s12045-022-1334-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12045-022-1334-1

Keywords

Search

Navigation