Abstract
In this part we shall outline the challenges one faces while developing time-domain radiofrequency (RF) EPR imaging spectrometer for in vivo studies. Time-domain or FT-EPR is quite a different animal compared to the CW modality. The evolution of FT-EPR instrumentation at the National Cancer Institute, NIH, USA and representative examples of application in cancer research are outlined in this article.
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S Subramanian and M C Krishna, Reference module in chemistry, molecular sciences and chemical engineering, CMSE:05870 In Vivo Electron Paramagnetic Resonance Imaging, and references therein.
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(left) Sankaran Subramanian is Professor of Chemistry at IIT Madras. His areas of research are magnetic resonance (EPR & NMR) spectroscopy, imaging and instrumentation.
(right) Murali C Krishna is the Chief of Biophysical Spectroscopy and Imaging Section of the National Cancer Institute, NIH, USA. His research encompasses free radicals, redox biology of nitroxides, CW- and FT-EPR imaging of tumor hypoxia, EPRI–MRI coregistration, etc.
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Subramanian, S., Krishna, M.C. Electron paramagnetic resonance imaging. Reson 21, 717–740 (2016). https://doi.org/10.1007/s12045-016-0377-6
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DOI: https://doi.org/10.1007/s12045-016-0377-6