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Eschenmoser approach to vitamin B12 by A/D strategy

An unexpected journey

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  1. A Eschenmoser, ‘RBW, Vitamin B12, and the Harvard-ETH Collaboration’ in Architect and Artist in the World of Chemistry, O T Benfey and P J T Morris, Eds., Chemical Heritage Foundation, Philadelphia, PA, Chapter 4, pp.23–38, 2001.

    Google Scholar 

  2. E Bertele, H Boos, D Dunitz, F Elsinger, A Eschenmoser, I Felner, H P Gribi, H Gschwend, E FMeyer, M Pesaro and R Scheffold, ASynthetic Route to the Corrin System, Angew. Chem. Int., Ed., Vol.3, No.7, pp.490–496, 1964.

    Article  Google Scholar 

  3. E J Sorensen, ‘Albert Eschenmoser’, Helv. Chim. Acta., Vol.83, pp.1673–1677, 2000.

    Article  Google Scholar 

  4. R BWoodward, Recent Advances in the Chemistry of Natural Products, Pure Appl. Chem., Vol.17, pp.519–547, 1968.

    Article  Google Scholar 

  5. K C Nicolaou and E J Sorensen, Eds., ‘Vitamin B12’ in Classics in Total Synthesis, VCH Verlagsgesellschaft: Weinheim, Chapter 8, pp.99–136, 1996.

    Google Scholar 

  6. O T Benfey and P J T Morris, Eds., ‘Vitamin B12’ in Architect and Artist in the World of Chemistry, Chemical Heritage Foundation, Philadelphia, PA, Chapter 15, pp.302–311, 2001.

    Google Scholar 

  7. W Friedrich, G Gross, K Bernhauer and P Zeller, Synthesen auf dem Vitamin-B12-Gebiet. Partial Synthese von Vitamin B12, Helv. Chim. Acta., Vol.43, pp.704–712, 1960.

    Article  Google Scholar 

  8. A R Battersby, Tetrapyrroles: the Pigments of Life, Nat. Prod. Rev., Vol.17, pp.507–526, 2000.

    Article  Google Scholar 

  9. K M Smith, Ed., Porphyrins and Metalloporphyrins, Elsevier Scientific Publishing Company, Oxford, pp.112–115, 1975.

    Google Scholar 

  10. R B Woodward, Recent Advances in the Chemistry of Natural Products, Pure Appl. Chem., Vol.25, pp.283–304, 1971.

    Article  Google Scholar 

  11. A Eschenmoser, Road to Corrins, Quarterly Reviews, Vol.24, pp.366–415, 1970.

    Article  Google Scholar 

  12. A Eschenmoser and C EWintner, Natural Product Synthesis and Vitamin B12, Science, Vol.196, pp.1410–1420, 1977.

    Article  Google Scholar 

  13. J W Cornforth, cited by P B F de la Mare, Nature, Vol.195, p.441, 1962.

    Google Scholar 

  14. R B Woodward, Recent Advances in the Chemistry of Natural Products, Pure Appl. Chem., Vol.22, pp.519–547, 1968.

    Google Scholar 

  15. A H Jackson and K M Smith, in The Total Synthesis of Natural Products’, Vol.1, Ed. J W ApSimon, Wiley-Interscience, New York, p.261, 1973.

  16. A Eschenmoser, Studies in Organic Synthesis, Pure Appl. Chem., Vol.2, p.69, 1971.

    Google Scholar 

  17. D Riether and J Mulzer, The Total Synthesis of Cobyric Acid: Historical Development and Recent Innovations, Eur. J. Org. Chem., Vol.1, pp.30–45, 2003.

    Article  Google Scholar 

  18. P A Jacobi, H L Brielmann, M Chiu, I Ghosh, S I Hauck, S Lanz, S Leung, Y Li, H Liu, F Löwer, W G O’Neal, D Pippin, E Pollina, B A Pratt, F Robert, W P Roberts, C Tassa and H Wang, The Synthesis of Biologically Important Tetrapyrroles, Heterocycles, Vol.82, No.2, pp.1029–1081, 2011.

    Article  Google Scholar 

  19. O T Benfey and P J T Morris, Eds., ‘The Woodward-Hoffmann Rules’ in Architect and Artist in the World of Chemistry, Chemical Heritage Foundation, Philadelphia, PA, Chapter 16, pp.343–349, 2001.

    Google Scholar 

  20. Y Yamada, D Miljkovic, P Wehrli, B Golding, P Loliger, R Keese, K Mueller and A Eschenmoser, A New Type of Corrin Synthesis, Angew. Chem. Int. Ed., Vol.8, No.5, pp.343–348, 1969.

    Article  Google Scholar 

  21. A Eschenmoser, Post-B12 Problems in Corrin Synthesis, Chem. Soc. Rev., pp.377–410, 1976.

    Google Scholar 

  22. J Fuhrop and G Penzlin, Organic Synthesis, Concepts, Methods, Starting Materials, VCH, Weinheim, pp.250–262, 1994.

    Google Scholar 

  23. R B Woodward, The Total Synthesis of Vitamin B12, Pure Appl. Chem., Vol.33, pp.145–177, 1973.

    Article  Google Scholar 

  24. A R Todd, ‘Robert Robinson (1886–1975)’. Nat. Prod. Rep., pp.3–11, 1987.

    Google Scholar 

  25. A Eschenmoser, B12: Experiments Concerning the Origin of its Molecular Structure, Angew. Chem. Int. Ed., Vol.27, No.1, pp.5–39, 1988.

    Article  Google Scholar 

  26. A Eschenmoser, B12: Reminiscences and Afterthoughts in The Biosynthesis of the Tetrapyrrole Pigments, Ed. Ciba Foundation Symposium, John Wiley & Sons, New York, pp.309–332, 1994.

    Google Scholar 

  27. M O Benedyk, Fundamental Questions: An Interviewwith Professor Albert Eschenmoser, Bol. Soc. Quím. Méx., Vol.2, No.2, pp.67–70, 2008.

    Google Scholar 

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  1. Lead Finding Research, Neumattstrasse 5, CH-4144, Arlesheim, Switzerland

    G. Wayne Craig

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  1. G. Wayne Craig
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Correspondence to G. Wayne Craig.

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This article is dedicated to Professor Kevin M Smith, recipient of the Robert Burns Woodward Award, 2006 on the occasion of his 72nd birthday.

G Wayne Craig, a native of Hawaii has an impressive academic record: PhD (Organic Synthesis, 1982), Post Doctoral (Organic synthesis, 1983–1985). Following a stint at Genentech Ltd and Zoecon Research Institute, he took up a permanent position as head of chemistry lab for fungicide research at Sandoz AG (1981). In 2008 he founded a company for lead finding. He is passionately interested in the history of chemistry and has written several articles on this domain.

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Craig, G.W. Eschenmoser approach to vitamin B12 by A/D strategy. Reson 19, 624–640 (2014). https://doi.org/10.1007/s12045-014-0064-4

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