This is a preview of subscription content, log in via an institution to check access.
References
Brunet A., Sweeney L. B., Sturgill J. F., Chua K. F., Greer P. L., Lin Y. et al. 2004 Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303, 2011–2015.
Chen X., Li S., Yang Y., Yang X., Liu Y., Liu Y. et al. 2012 Genome-wide association study validation identifies novel loci for atherosclerotic cardiovascular disease. J. Thromb. Haemost. 10, 1508–1514.
Clarke R., Emberson J., Fletcher A., Breeze E., Marmot M. and Shipley M. J. 2009 Life expectancy in relation to cardiovascular risk factors: 38 year follow-up of 19,000 men in the Whitehall Study. BMJ 339, b3513.
Fan X. M. 2013 The research of longevity population of the sixth census in China. Popul. J. 35, 14–20.
Levy D., Larson M. G., Benjamin E. J., Newton-Cheh C., Wang T. J., Hwang S. J. et al. 2007 Framingham Heart Study 100K project: genome-wide associations for blood pressure and arterial stiffness. BMC Med. Genet. 8(Suppl 1), S3.
Lin P. I., Vance J. M., Pericak-Vance M. A. and Martin E. R. 2007 No gene is an island: the flip–flop phenomenon. Am. J. Hum. Genet. 80, 531–538.
Malovini A., Illario M., Iaccarino G., Villa F., Ferrario A., Roncarati R. et al. 2011 Association study on long-living individuals from southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins. Rejuvenation Res. 14, 283–291.
Nojima A., Yamashita M., Yoshida Y., Shimizu I., Ichimiya H., Kamimura N. et al. 2013 Haploinsufficiency of akt1 prolongs the lifespan of mice. PLoS One 8, e69178.
Pawlikowska L., Hu D., Huntsman S., Sung A., Chu C., Chen J. et al. 2009 Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevity. Aging Cell 8, 460–472.
Santulli G., Cipolletta E., Sorriento D., Del Giudice C., Anastasio A., Monaco S. et al. 2012 CaMK4 gene deletion induces hypertension. J. Am. Heart. Assoc. 1, e001081.
Tissenbaum H. A. and Guarente L. 2001 Increased dosage of a SIR-2 gene extends lifespan in Caenorhabditis elegans. Nature 410, 227–230.
Willcox B. J., Donlon T. A., He Q., Chen R., Grove J. S., Yano K. et al. 2008 FOXO3A genotype is strongly associated with human longevity. Proc. Natl. Acad. Sci. USA 105, 13987– 13992.
Zaykin D. V. and Shibata K. 2008 Genetic flip–flop without an accompanying change in linkage disequilibrium. Am. J. Hum. Genet. 82, 794–796 ; author reply 796–797.
Acknowledgements
This work was supported by grants from the National Natural Science Foundation of China (31460290), Department of Science and Technology of Hainan Province (KJHZ2013-16 and ZDXM20090805), the Research Start-Up Fund in Hainan Medical College for Dr Lin, the Young Scientists Fund of the National Natural Science Foundation of China (31100904), Fund for Less Developed Regions of the National Natural Science Foundation of China (81460184). We thank Dr Zhengwen Jiang, Dr Yan Liu, and Dr Ying Wang (Genesky Biotechnologies, Shanghai, China) for technical support.
Author information
Authors and Affiliations
Corresponding authors
Additional information
[Lin R., Zhang Y., Yan D., Liao X., Fu Y. and Cai W. 2016 Lack of association between rs10491334 in the CAMK4 gene and longevity in a Chinese population. J. Genet. 95, xx–xx]
Rights and permissions
About this article
Cite this article
LIN, R., ZHANG, Y., YAN, D. et al. Lack of association between rs10491334 in the CAMK4 gene and longevity in a Chinese population. J Genet 95, 729–732 (2016). https://doi.org/10.1007/s12041-016-0677-3
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12041-016-0677-3