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Human genetics of diabetic vascular complications

Journal of Genetics volume 92, pages 677–694 (2013)Cite this article

Abstract

Diabetic vascular complications (DVC) affecting several important organ systems of human body such as the cardiovascular system constitute a major public health problem. There is evidence demonstrating that genetic factors contribute to the risk of DVC genetic variants, structural variants, and epigenetic changes play important roles in the development of DVC. Genetic linkage studies have uncovered a number of genetic loci that may shape the risk of DVC. Genetic association studies have identified many common genetic variants for susceptibility to DVC. Structural variants such as copy number variation and interactions of gene × environment have also been detected by association analysis. Apart from the nuclear genome, mitochondrial DNA plays a critical role in regulation of development of DVC. Epigenetic studies have indicated epigenetic changes in chromatin affecting gene transcription in response to environmental stimuli, which provided a large body of evidence of regulating development of diabetes mellitus. Recently, a new window has opened on identifying rare and common genetic loci through next generation sequencing technologies. This review focusses on the current knowledge of the genetic and epigenetic basis of DVC. Ultimately, identification of genes or genetic loci, structural variants and epigenetic changes contributing to risk of or protection from DVC will help uncover the complex mechanism(s) underlying DVC, with crucial implications for the development of personalized medicine for diabetes mellitus and its complications.

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Acknowledgements

We thank the grant from China National Grant on Science and Technology (30570740) to support the study.

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Affiliations

  1. Department of Endocrinology and Metabolism, Fudan University Huashan Hospital, Shanghai, 200040, People’s Republic of China

    ZI-HUI TANG, ZHOU FANG & LINUO ZHOU

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  1. ZI-HUI TANG
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  2. ZHOU FANG
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  3. LINUO ZHOU
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Correspondence to LINUO ZHOU.

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[Tang Z.-H., Fang Z. and Zhou L. 2013 Human genetics of diabetic vascular complications. J. Genet. 92, xx–xx]

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TANG, ZH., FANG, Z. & ZHOU, L. Human genetics of diabetic vascular complications . J Genet 92, 677–694 (2013). https://doi.org/10.1007/s12041-013-0288-1

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Keywords

  • diabetic vascular complications
  • genetics
  • epigenetic
  • mitochondrial DNA
  • interactions of gene × environment