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Journal of Genetics

, Volume 91, Issue 3, pp 363–366 | Cite as

Expression pattern of PRM2, HSP90 and WNT5A in male partners of couples experiencing idiopathic recurrent miscarriages

  • KISHLAY KUMAR
  • DIPIKA DEKA
  • ANAND SINGH
  • PARTHAPRASAD CHATTOPADHYAY
  • RIMA DADA
Research Note
  • 75 Downloads

Introduction

Recurrent pregnancy loss affects approximately 3–5% of couples attempting to have a child. It is defined as the occurrence of two or more consecutive pregnancy failures before 20 weeks of gestation. In about 40% of cases, the cause remains unknown and are defined as idiopathic recurrent miscarriages (iRM) (Stephenson and Kutteh 2007). However, most of these diagnostics tests are performed in the female partner, with the male’s contribution remaining relatively underexplored (only paternal karyotyping is done). Paternal factor may be the underlying aetiology in RM (Lalancette et al.2008) and molecular abnormalities in sperm may have an adverse effect on embryonic development. Certain portion of sperm genome remains transcriptionally active and codes for transcripts which are of paramount developmental importance (Krawetz 2005; Gil-Villa et al.2010). Among these, the role of long-lived sperm RNA which are not translated is controversial. Sperm possess a remarkable set of...

Keywords

recurrent miscarriages spermatozoa mRNA PRM2 gene WNT5A gene  HSP90 gene 

Notes

Acknowledgement

Financial support from Department of Biotechnology (no. BT/PR13558/MED/30/282/2010), Government of India is highly acknowledged.

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Copyright information

© Indian Academy of Sciences 2012

Authors and Affiliations

  • KISHLAY KUMAR
    • 1
  • DIPIKA DEKA
    • 2
  • ANAND SINGH
    • 3
  • PARTHAPRASAD CHATTOPADHYAY
    • 3
  • RIMA DADA
    • 1
  1. 1.Laboratory for Molecular Reproduction and Genetics, Department of AnatomyAll India Institute of Medical SciencesNew DelhiIndia
  2. 2.Department of Obstetrics and GynaecologyAll India Institute of Medical SciencesNew DelhiIndia
  3. 3.Department of BiochemistryAll India Institute of Medical SciencesNew DelhiIndia

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