Journal of Genetics

, Volume 91, Issue 3, pp 349–352 | Cite as

Endothelial nitric oxide synthase polymorphism G298T in association with oxidative DNA damage in coronary atherosclerosis

Research Note


coronary artery disease endothelial nitric oxide synthase myocardial infarction reactive oxygen species 

Supplementary material

12041_2012_183_MOESM1_ESM.pdf (419 kb)
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  1. Ahuja Y. R. and Saran R. 1999 Alkaline single cell gel electrophoresis assay. I. Protocol. J. Cytol. Genet. 34, 57–62.Google Scholar
  2. Dafni C., Drakoulis N., Landt O., Panidis D., Reczko M. and Cokkinos D. V. 2010 Association of the eNOS E298D polymorphism and the risk of myocardial infarction in the Greek population. BMC Med. Genet. 11, 133–139.PubMedCrossRefGoogle Scholar
  3. De C. R. 2000 Endothelial dysfunctions: common denominators in vascular disease. Curr. Opin. Lipidol. 11, 9–23.CrossRefGoogle Scholar
  4. Gandhi G. and Singh B. 2004 DNA damage studies in untreated and treated leprosy patients. Mutagenesis 19, 483–488.PubMedCrossRefGoogle Scholar
  5. Hibi K., Ishigami T., Tamura K., Mizushima S., Nyui N., Fujita T. et al. 1998 Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction. Hypertension 32, 521–526.PubMedCrossRefGoogle Scholar
  6. Hingorani A. D., Liang C. F., Fatibene J., Lyon A., Monteith S., Parsons A. et al. 1999 A common variant of the endothelial nitric oxide synthase (Glu(298)–Asp) is a major risk factor for coronary artery disease in the UK. Circulation 100, 1515– 1520.PubMedCrossRefGoogle Scholar
  7. Isabella D. D., Ranieri R., Roberto C., Daniela G. and Aldo M. 2006 Biomarkers of oxidative damage in human disease. Clin. Chem. 52, 601–623.CrossRefGoogle Scholar
  8. Kathy K. G. and Garret A. F. 2003 Part I: basic mechanisms and in vivo monitoring of ROS. Circulation 108, 1912–1916.CrossRefGoogle Scholar
  9. Lembo G., De L. N., Battagli C., Iovino G., Aretini A., Musicco M. et al. 2001 A common variant of endothelial nitric oxide synthase (Glu298Asp) is an independent risk factor for carotid atherosclerosis. Stroke 32, 735–740.PubMedCrossRefGoogle Scholar
  10. Loscalzo J. and Welch G. 1995 Nitric oxide and its role in the cardiovascular system. Prog. Cardiovasc. Dis. 38, 87–104.PubMedCrossRefGoogle Scholar
  11. Mahmoudi M., Mercer J. and Bennett M. 2006 DNA damage and repair in atherosclerosis. Cardiovasc. Res. 71, 259–268.PubMedCrossRefGoogle Scholar
  12. Markus H. S., Ruigrok Y., Ali N. and Powell J. F. 1998 Endothelial nitric oxide synthase exon 7 polymorphism, ischemic cerebrovascular disease, and carotid atheroma. Stroke 29, 1908–1911.PubMedCrossRefGoogle Scholar
  13. Martin R. B. 2001 Reactive oxygen species and death oxidative DNA damage in atherosclerosis. Circ. Res. 88, 648–650.CrossRefGoogle Scholar
  14. Nakayama M., Yasue H., Yoshimura M., Shimasaki Y., Kugiyama K., Ogawa H. et al. 1999 T- 786- C mutation in the 50 flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 99, 2864–2870.PubMedCrossRefGoogle Scholar
  15. Nakayama T., Soma M., Takahashi Y., Izumi Y., Kanmatsuse K. and Esumi M. 1997 Association analysis of CA repeat polymorphism of the endothelial nitric oxide synthase gene with essential hypertension in Japanese. Clin. Genet. 51, 26–30.PubMedCrossRefGoogle Scholar
  16. Nishevitha N. S., Angeline T. and Nirmala J. 2009 Endothelial nitric oxide synthase (eNOS) Glu298Asp polymorphism (G894T) among south Indians. Indian J. Med. Res. 129, 68–71.PubMedGoogle Scholar
  17. Poirier O., Mao C., Mallet C., Nicaud V., Herrmann S. M., Evans A. et al. 1999 Polymorphisms of the endothelial nitric oxide synthase gene no consistent association with myocardial infarction in the ECTIM study. Eur. J. Clin. Invest. 29, 284–290.PubMedCrossRefGoogle Scholar
  18. Radomski M. W., Palmer R. M. and Moncada S. 1887 Endogenous nitric oxide inhibitshuman platelet adhesion to vascular endothelium. Lancet 2, 1057–1058.Google Scholar
  19. Shimasaki Y., Yasue H., Yoshimura M., Nakayama M., Kugiyama K., Ogawa H. et al. 1998 endothelial nitric oxide synthase: the influence of cofactors. Proc. Natl. Acad. Sci. USA 95, 9220–9225.CrossRefGoogle Scholar
  20. Singh N. P., McCoy M. T., Tice R. R. and Schneider E. L. 1988 A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 175, 184–191.PubMedCrossRefGoogle Scholar
  21. Sukanta M., Joyti B. S., Sankar C. M., Rudra N. B., Manashi C. and Partha P. P. 2009 Prevalence of ischemic heart disease among urban population of Siliguri, West Bengal. Indian J. Community Med. 34, 19–23.CrossRefGoogle Scholar
  22. Wang W., Wang S., Yan L., Madara P., Del P. C. A., Wesley R. A. et al. 2000 Superoxide production and reactive oxygen species signaling by endothelial nitric-oxide synthase. J. Biol. Chem. 275, 16899–16903.PubMedCrossRefGoogle Scholar

Copyright information

© Indian Academy of Sciences 2012

Authors and Affiliations

    • 1
    • 1
    • 1
    • 2
    • 1
  1. 1.Department of GeneticsOsmania UniversityHyderabadIndia
  2. 2.Durgabai Deshmukh Hospital and Research CentreHyderabadIndia

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