References
Amos C. I., Keitheri-Cheteri M. B., Sabripour M., Wei C., McGarrity T. J., Seldin M. F. et al. 2004 Genotype–phenotype correlations in Peutz–Jeghers syndrome. J. Med. Genet. 41, 327–333.
Beggs A. D., Latchford A. R., Vasen H. F., Moslein G., Alonso A., Aretz S. et al. 2010 Peutz–Jeghers syndrome: a systematic review and recommendations for management. Gut 59, 975–986.
Boudeau J., Baas A. F., Deak M., Morrice N. A., Kieloch A., Schutkowski M. et al. 2003 MO25alpha/beta interact with STRA Dalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J. 22, 5102–5114.
Forcet C., Etienne-Manneville S., Gaude H., Fournier L., Debilly S., Salmi M. et al. 2005 Functional analysis of Peutz–Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity. Hum. Mol. Genet. 14, 1283–1292.
Hearle N., Schumacher V., Menko F. H., Olschwang S., Boardman L. A., Gille J. J. et al. 2006 Frequency and spectrum of cancers in the Peutz–Jeghers syndrome. Clin. Cancer Res. 12, 3209–3215.
Karuman P., Gozani O., Odze R. D., Zhou X. C., Zhu H., Shaw R. et al. 2001 The Peutze–Jeghers gene product LKB1 is a mediator of p53-dependent cell death. Mol. Cell 7, 1307–1319.
Lin-Marq N., Borel C. and Antonarakis S. E. 2005 Peutze–Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling. Mol. Genet. Genomics 273, 184–196.
Morton D. G., Roos J. M. and Kemphues K. J. 1992 Par-4, a gene required for cytoplasmic localization and determination of specific cell types in Caenorhabditis elegans embryogenesis. Genetics 130, 771–790.
Sapkota G. P., Deak M., Kieloch A., Morrice N., Goodarzi A. A., Smythe C. et al. 2002 Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. Biochem. J. 368, 507–516.
Tiainen M., Ylikorkala A. and Makela T. P. 1999 Growth suppression by Lkb1 is mediated by a G (1) cell cycle arrest. Proc. Natl. Acad. Sci. USA 96, 9248–9251.
Yoo L. I., Chung D. C. and Yuan J. 2002 LKB1 - a master tumour suppressor of the small intestine and beyond. Nat. Rev. Cancer 2, 529–535.
Author information
Authors and Affiliations
Corresponding author
Additional information
[Liu D., Guo H., Xu X., Yu Y. and Bai Y. 2012 Two variants in STK11 gene in Chinese patients with Peutz–Jeghers syndrome. J. Genet. 91, xx–xx]
Rights and permissions
About this article
Cite this article
LIU, D., GUO, H., XU, X. et al. Two variants in STK11 gene in Chinese patients with Peutz–Jeghers syndrome. J Genet 91, 205–208 (2012). https://doi.org/10.1007/s12041-012-0152-8
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12041-012-0152-8