References
Arriagada C., Bustamante M., Atwater I., Rojas E., Caviedes R. and Caviedes P. 2010 Apoptosis is directly related to intracellular amyloid accumulation in a cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome. Neurosci. Lett. 470, 81–85.
D’Amours D., Desnoyers S., D’Silva I. and Poirier G. G. 1999 Poly (ADP-ribosyl) ation reactions in the regulation of nuclear functions. Biochem J. 342, 249–268.
Elmore S. 2007 Apoptosis: a review of programmed cell death. Toxicol. Pathol. 35, 495–516.
Engidawork E., Balic N., Juranville J. F., Fountoulakis M., Dierssen M. and Lubec G. 2001 Unaltered expression of Fas (CD95/APO-1), caspase-3, Bcl-2 and annexins in brains of fetal Down syndrome: evidence against increased apoptosis. J. Neural. Transm. Suppl. 61, 149–162.
Eustermann S., Videler H., Yang J. C., Cole P. T., Gruszka D., Veprintsev D. et al. 2011 The DNA-binding domain of human PARP-1 interacts with DNA single-strand breaks as a monomer through its second zinc finger. J. Mol. Biol. 407, 149–170.
Fromage B. and Anglade P. 2002 The aging of Down’s Syndrome subjects. Encephale 28, 212–226.
Grube K. and Bürkle A. 1992 A Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span. Proc. Natl. Acad. Sci. USA 89, 11759–11763.
Hassa P. O. and Hottiger M. O. 2008 The diverse biological roles of mammalian PARPs, a small but powerful family of poly-ADP-ribose polymerases. Front Biosci. 13, 3046–3082.
Hassa P. O., Haenni S. S., Elser M. and Hottiger M. O. 2006 Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going? Microbiol. Mol. Biol. Rev. 70, 789–829.
Hu W. and Kavanagh J. J. 2003 Anticancer therapy targeting the apoptotic pathway. Lancet Oncol. 4, 721–729.
Jagtap P. and Szabo C. 2005 Poly (ADP-ribose) polymerase and the therapeutic effects of its inhibitors. Nat. Rev. Drug Discov. 4, 421–440.
Kannan S., Fang W., Song G., Mullighan C. G., Hammitt R., McMurray J. et al. 2011 Notch/HES1-mediated PARP1 activation: a cell-type specific mechanism for tumor suppression. Blood 117, 2891–2900.
Langelier M. F., Ruhl D. D., Planck J. L., Kraus W. L. and Pascal J. M. 2010 The Zn3 domain of human poly(ADP-ribose) polymerase-1 (PARP-1) functions in both DNA-dependent poly(ADP-ribose) synthesis activity and chromatin compaction. J. Biol. Chem. 285, 18877–18887.
Livak K. J. and Schmittgen T. D. 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)). Method 4, 402–408.
Nicholson D. W., Ali A., Thornberry N. A., Vaillancourt J. P., Ding C. K., Gallant M. et al. 1995 Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376, 137–143.
Paquet-Durand F., Silva J., Talukdar T., Jonhnson L. E., Azadi S., van Veen T. et al. 2007 Excessive activation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinal degeneration 1 mouse. J. Neurosci. 27, 10311–10319.
Sahaboglu A., Tanimoto N., Kaur J., Sancho-Pelluz J., Huber G., Fahl E. et al. 2010 PARP1 gene knock-out increases resistance to retinal degeneration without affecting retinal function. PLoS ONE 11, e15495.
Schreiber V., Dantzer F., Ame J. C. and de Murcia G. 2006 Poly(ADP-ribose): novel functions for an old molecule. Nat. Rev. Mol. Cell. Biol. 7, 517–528.
Wisniewski K. E., Dalton A. J., McLachlan C., Wen G. Y. and Wisniewski H. M. 1985 Alzheimer’s disease in Down’s syndrome: clinicopathologic studies. Neurology 35, 957–961.
Yu S. W., Andrabi S. A. and Wang H. 2006 Apoptosis-inducing factor mediates poly (ADP-ribose) (PAR) polymer-induced cell death. Proc. Natl. Acad. Sci. USA 103, 18314–18319.
Author information
Authors and Affiliations
Corresponding author
Additional information
Salemi M., Barone C., Romano C., Ridolfo F., Gulotta E., Scavuzzo C., Salluzzo M. G., Giambirtone M., Caraci F., Romano C. and Bosco P. 2011 Differential expression of PARP1 mRNA in leucocytes of patients with Down’s syndrome. J. Genet. 90, xx–xx
These authors contributed equally to this work. (Michele Salemi & Concetta Barone)
Rights and permissions
About this article
Cite this article
SALEMI, M., BARONE, C., ROMANO, C. et al. Differential expression of PARP1 mRNA in leucocytes of patients with Down’s syndrome. J Genet 90, 469–472 (2011). https://doi.org/10.1007/s12041-011-0074-x
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12041-011-0074-x