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Common variants in the gene for the serotonin receptor 6 (HTR6) do not contribute to obesity

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References

  • Alberti K. G. and Zimmet P. Z. 1998 Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet. Med. 15, 539–553.

    Article  PubMed  CAS  Google Scholar 

  • Barrett J. C., Fry B., Maller J. and Daly M. J. 2005 Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263–265.

    Article  PubMed  CAS  Google Scholar 

  • Chambers J. C., Elliott P., Zabaneh D., Zhang W., Li Y., Froguel P. et al. 2008 Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat. Genet. 40, 716–718.

    Article  PubMed  CAS  Google Scholar 

  • de Bakker P. I., Yelensky R., Pe’er I., Gabriel S. B., Daly M. J. and Altshuler D. 2005 Efficiency and power in genetic association studies. Nat. Genet. 37, 1217–1223.

    Article  PubMed  Google Scholar 

  • DeFronzo R. A. and Ferrannini E. 1991 Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabet. Care 14, 173–194.

    Article  CAS  Google Scholar 

  • Frassetto A., Zhang J., Lao J. Z., White A., Metzger J. M., Fong T. M. et al. 2008 Reduced sensitivity to diet-induced obesity in mice carrying a mutant 5-HT6 receptor. Brain Res. 1236, 140–144.

    Article  PubMed  CAS  Google Scholar 

  • Frayling T. M., Timpson N. J., Weedon M. N., Zeggini E., Freathy R. M., Lindgren C. M. et al. 2007 A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316, 889–894.

    Article  PubMed  CAS  Google Scholar 

  • Frazer K. A., Ballinger D. G., Cox D. R., Hinds D. A., Stuve L. L., Gibbs R. A. et al. 2007 A second generation human haplotype map of over 3.1 million SNPs. Nature 449, 851–861.

    Article  PubMed  CAS  Google Scholar 

  • Loos R. J., Lindgren C. M., Li S., Wheeler E., Zhao J. H., Prokopenko I. et al. 2008 Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat. Genet. 40, 768–775.

    Article  PubMed  CAS  Google Scholar 

  • Maes H. H., Neale M. C. and Eaves L. J. 1997 Genetic and environmental factors in relative body weight and human adiposity. Behav. Genet. 27, 325–351.

    Article  PubMed  CAS  Google Scholar 

  • Peeters A. V., Beckers S., Verrijken A., Mertens I., Roevens P., Peeters P. J. et al. 2008 Association of SIRT1 gene variation with visceral obesity. Hum. Genet. 124, 431–436.

    Article  PubMed  CAS  Google Scholar 

  • Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M. A., Bender D. et al. 2007 PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559–575.

    Article  PubMed  CAS  Google Scholar 

  • Skol A. D., Scott L. J., Abecasis G. R. and Boehnke M. 2006 Joint analysis is more efficient than replication-based analysis for twostage genome-wide association studies. Nat. Genet. 38, 209–213.

    Article  PubMed  CAS  Google Scholar 

  • Thorleifsson G., Walters G. B., Gudbjartsson D. F., Steinthorsdottir V., Sulem P., Helgadottir A. et al. 2009 Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat. Genet. 41, 18–24.

    Article  PubMed  CAS  Google Scholar 

  • Willer C. J., Speliotes E. K., Loos R. J., Li S., Lindgren C. M., Heid I. M. et al. 2009 Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet. 41, 25–34.

    Article  PubMed  CAS  Google Scholar 

  • Yang W., Kelly T. and He J. 2007 Genetic epidemiology of obesity. Epidemiol. Rev. 29, 49–61.

    Article  PubMed  Google Scholar 

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Correspondence to Wim van Hul.

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These authors contributed equally to this work.

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Peeters, A.V., Beckers, S., Verrijken, A. et al. Common variants in the gene for the serotonin receptor 6 (HTR6) do not contribute to obesity. J Genet 89, 469 (2010). https://doi.org/10.1007/s12041-010-0066-2

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  • DOI: https://doi.org/10.1007/s12041-010-0066-2

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