Genetic landscape of the people of India: a canvas for disease gene exploration
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Analyses of frequency profiles of markers on disease or drug-response related genes in diverse populations are important for the dissection of common diseases. We report the results of analyses of data on 405 SNPs from 75 such genes and a 5.2 Mb chromosome, 22 genomic region in 1871 individuals from diverse 55 endogamous Indian populations. These include 32 large (> 10 million individuals) and 23 isolated populations, representing a large fraction of the people of India. We observe high levels of genetic divergence between groups of populations that cluster largely on the basis of ethnicity and language. Indian populations not only overlap with the diversity of HapMap populations, but also contain population groups that are genetically distinct. These data and results are useful for addressing stratification and study design issues in complex traits especially for heterogeneous populations.
KeywordsIndian genome variation polymorphism SNP Asia HapMap complex disease pharmacogenomics
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- Drysdale C. M., McGraw D. W., Stack C. B., Stephens J. C., Judson R. S., Nandabalan K. et al. 2000 Complex promoter and coding region beta 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc. Natl. Acad. Sci. USA 97, 10483–10488.PubMedCrossRefGoogle Scholar
- Fogarty M. S., Sinha A. K., and Jaffe A. B. 2006, ATP and the U.S. Innovation System: A Methodology for Identifying Enabling R&D Spillover Networks Gaithersburg, NIST GCR 06-895.Google Scholar
- Habib I. 2001 People’s History of India — Part I: Prehistory Aligarh Historians Society and Tulika Books, Aligarh.Google Scholar
- Habib I. 2002 People’s History of India Part 2: The Indus Civilization. Aligarh Historians Society and Tulika Books, Aligarh.Google Scholar
- Papolos D. F., Faedda G. L., Veit S., Goldberg R., Morrow B., Kucherlapati R. et al. 1996 Bipolar spectrum disorders in patients diagnosed with velo-cardio-facial syndrome: does a hemizygous deletion of chromosome 22q11 result in bipolar affective disorder? Am. J. Psychiatry 153, 1541–1547.PubMedGoogle Scholar
- Rao C. R. 1952 p. 390 Advanced Statistical Methods in Biometric Research, John Wiley, New York.Google Scholar
- Sengupta S., Zhivotovsky L. A., King R., Mehdi S. Q., Edmonds C. A., Chow C. E. et al. 2006 Polarity and temporality of highresolution Y-chromosome distributions in India identify both indigenous and exogenous expansions and reveal minor genetic influence of central asian pastoralists. Am. J. Hum. Genet. 78, 202–221.PubMedCrossRefGoogle Scholar
- Singh K. S. 2002 People of India: introduction national series. Oxford University Press, Delhi.Google Scholar
- Sinha A. K. 2001 A Fuzzy Measure Theoretic Quantum Approximation of an Abstract System, Case Western Reserve University Cleveland, Ohio.Google Scholar
- Sinha A. K., Richoux W. J. and Loparo K. A. 2004 A system-theoretic state description for temporal transitions in electroencephalogram data of severe epileptic patients, 43rd IEEE Conference on Decision and Control, Atlantis, Paradise Island, Bahamas.Google Scholar
- Thapar R. 1966 A history of India. Penguin Books, London.Google Scholar