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Deoxygenation of sulfoxides using D-camphorsulfonic acid as an efficient reducing agent under metal and additive-free conditions

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Abstract

A novel strategy for the chemoselective conversion of sulfoxides to sulfide utilizing D-camphorsulfonic acid (D-CSA) as a reducing reagent has been developed under metal and additive-free conditions. A variety of sulfoxides such as alkyl–aryl, allyl–aryl, benzyl–aryl, aryl–ethyl sulfoxides have been effectively utilized to achieve the corresponding reduced products in good to excellent yields under mild conditions without any additive. The proposed method offers a practical solution for the deoxygenation of sulfoxides, which has potential applications in various fields such as pharmaceuticals, materials science, and organic synthesis.

Graphical abstract

A novel strategy for the chemoselective deoxygenation of diverse sulfoxides without metal and additive has been disclosed using D-camphorsulfonic acid (D-CSA) as the reducing agent. The reaction proceeds under mild conditions to afford the sulphides in moderate to good yields with great tolerance of diverse functional groups.

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Acknowledgements

Joshi A and Sandeep Singh are thankful to NIT Uttarakhand and CSIR, New Delhi, respectively, for their fellowships. The authors are thankful to NIT Uttarakhand and TEQIP-III for financial support. The funding from DST-SERB, New Delhi (103/2014 dt. 18.07.2015) is also greatly acknowledged.

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  1. Department of Chemistry, National Institute of Technology, Uttarakhand, Srinagar-Garhwal, Uttarakhand, 246174, India

    Asha Joshi, Sandeep Singh & Saroj Ranjan De

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  1. Asha Joshi
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  2. Sandeep Singh
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Correspondence to Saroj Ranjan De.

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Joshi, A., Singh, S. & De, S.R. Deoxygenation of sulfoxides using D-camphorsulfonic acid as an efficient reducing agent under metal and additive-free conditions. J Chem Sci 136, 33 (2024). https://doi.org/10.1007/s12039-024-02261-x

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  • DOI: https://doi.org/10.1007/s12039-024-02261-x

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