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Imine linked AntiBSA@NUS-15 for molecular sensing applications

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Abstract

1,3,5-tris-(4 formyl phenyl) benzene and p-Phenylenediamine based covalent organic framework (COF) i.e., National University of Singapore-15 (NUS-15) have been synthesized using the solvothermal method at room temperature. Importantly, synthesized NUS-15 has been analysed using powdered X-ray diffraction (PXRD), Field emission scanning electron microscopy (FE-SEM), Infrared and UV-Visible spectroscopy techniques. Afterward, the optical properties of NUS-15 (excitation wavelength = 298 nm, emission wavelength = 404 nm) were confirmed through a photoluminescence spectrophotometer. Later on, biofunctionalization of NUS-15 was performed with Anti-BSA using coordination chemistry and confirmed through various analysis techniques. Based on optical properties, NUS-15-based Bioconjugate i.e., Anti-BSA@ NUS-15, has been utilized for selective sensing applications and noted 0.366 ppm detection limit for BSA. Our results imply that NUS-15 might be applied in future biomedical applications.

Graphical abstract

Synopsis. In this work, a covalent organic framework i.e., NUS-15 was synthesised and characterised for Anti-BSA tagged through simple coordination chemistry. Later, Anti BSA-tagged NUS-15 was explored for selective BSA sensing in a certain range using a photoluminescence spectrophotometer. Our results confirm 1.11 ppm (limit of quantification) and 0.366 ppm (limited of detection) during BSA detection.

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Acknowledgements

We want to express our gratitude to the Science and Engineering Research Board (SERB) in New Delhi for providing financial support through the “Early Carrier Research Grant” (Project’s reference no. ECR/2018/001716) programme. I, Gagandeep Kaur, would like to express my sincere thanks to the Central University of Jammu, India, for awarding me a Doctoral Fellowship so that I can finish my research.

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  1. Material Application Research Laboratory (MARL), Department of Nano Science and Materials, Central University of Jammu, Jammu, 181143, India

    Gagandeep Kaur & Pawan Kumar

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  1. Gagandeep Kaur
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  2. Pawan Kumar
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Correspondence to Pawan Kumar.

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Kaur, G., Kumar, P. Imine linked AntiBSA@NUS-15 for molecular sensing applications. J Chem Sci 135, 21 (2023). https://doi.org/10.1007/s12039-023-02147-4

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  • DOI: https://doi.org/10.1007/s12039-023-02147-4

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