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A facile and efficient synthesis of Bis-thiazole from mono-thiazole

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Abstract

This paper describes a facile route for the synthesis of bis-thiazoles from mono-thiazole with an eco-friendly method. The synthetic procedure for the synthesis of bis-thiazoles from the reaction of 2-amino-4-tolyl thiazole with different aromatic aldehydes under microwave irradiations is discussed. Structures of the final products are characterized by IR, 1H and 13C- NMR spectra, DEPT-135 and mass spectrometry.

Graphical abstract

A facile method is developed to synthesis bis-amino thiazole from easily synthesised mono thiazole. A series of bis thiazole were obtained with free amino groups which can be used for late-stage synthesis of new bis heterocyclic compounds.

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Acknowledgements

I am thankful to the UGC, New Delhi, India, for financial support under College for Potential and Excellence research Grant. I acknowledge the guidance and support provided by Dr. Dharminder Singh Ubha, Principal, G.S.S.D.G.S. Khalsa College, Patiala.

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  1. Department of Chemistry, GSSDGS Khalsa College, Patiala, Punjab, 147001, India

    Monika Bansal

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  1. Monika Bansal
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Correspondence to Monika Bansal.

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Bansal, M. A facile and efficient synthesis of Bis-thiazole from mono-thiazole. J Chem Sci 134, 36 (2022). https://doi.org/10.1007/s12039-022-02030-8

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  • DOI: https://doi.org/10.1007/s12039-022-02030-8

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