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Ruthenium, rhodium and iridium complexes containing diazafluorene derivative ligands: synthesis and biological studies

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Abstract

Reaction of [(arene)MCl2]2 with bidentate 4, 5-diazafluorene-9-one (dafo) and derived Schiff-base ligands (L1–L3) in the presence of ammonium hexafluorophosphate yielded mononuclear cationic complexes having general formula [(arene)MLCl]PF6 {M = Ru, arene = benzene (1, 5, 9); M = Ru, arene = p-cymene (4, 8); M = Rh, arene = Cp* (2, 6, 10); M = Ir, arene = Cp* (3, 7, 11); L = 4, 5-diazafluorene-9-one (L1), N-(4, 5-diazafluoren-9-ylidene)aniline (L2), N-(4, 5-diazafluoren-9-ylidene)phenyl hydrazine (L3)}. All these complexes were isolated as hexafluorophosphate salts and characterized by spectral and analytical techniques such as FT-IR, UV-vis, NMR spectroscopy and ESI-Mass spectrometry. Complexes 1-3 were characterized by X-ray crystallographic studies, which indicated NN′ bidentate coordination of the ligands through pyridine nitrogen atoms of the ligand. To evaluate the biological properties of these complexes, antibacterial and antioxidant experiments have been carried out. The complexes 8, 9 and 11 exhibited antibacterial activity against Gram-positive bacteria. Results also show that the compounds possess prominent antioxidant activity against DPPH radicals.

Graphical abstract

The reaction of [(arene)MCl2]2 with 4, 5- diazafluorene-9-one (dafo) and derived Schiff-base ligands yielded mononuclear cationic complexes having the general formula [(arene)MLCl]PF6. Some of the complexes exhibited antibacterial activity against Gram-positive bacteria. Results also show that the compounds possess prominent antioxidant activity against DPPH radicals.

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Acknowledgment

Carley Giffert L Nongpiur is grateful to Larica Pathaw for her help in the initial stages of this work. Carley also thanks Professor A. K. Singh, Department of Biochemistry, NEHU, SAIF-CDRI, Lucknow and SAIF-NEHU, Shillong for spectral analyses.

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Authors and Affiliations

  1. Centre for Advanced Studies in Chemistry, North-Eastern Hill University, Shillong, 793 022, India

    Carley Giffert L Nongpiur & Mohan Rao Kollipara

  2. Department of Biotechnology and Centre for Nanotechnology, Indian Institute of Technology Roorkee, Roorkee, 247 667, India

    Deepak Kumar Tripathi & Krishna Mohan Poluri

  3. Central Ayurveda Research Institute, Jhansi, 284003, India

    Hemant Rawat

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  1. Carley Giffert L Nongpiur
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  2. Deepak Kumar Tripathi
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  3. Krishna Mohan Poluri
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  5. Mohan Rao Kollipara
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Correspondence to Mohan Rao Kollipara.

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Nongpiur, C.G.L., Tripathi, D.K., Poluri, K.M. et al. Ruthenium, rhodium and iridium complexes containing diazafluorene derivative ligands: synthesis and biological studies. J Chem Sci 134, 23 (2022). https://doi.org/10.1007/s12039-021-02004-2

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