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Facile NBS/DMSO mediated dibromination of olefins including selected natural products and glycals

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Abstract

A highly chemo- and diastereoselective vic-dibromination of olefins has been developed. The process employs a readily available N-Bromosuccinimide (NBS)/DMSO reagent system as a bromine source. High substrate scope, simple reaction conditions, application to natural products and glycals makes the process very attractive.

Graphical abstract

A highly chemo- and diastereoselective vic-dibromination of olefins has been developed. The process employs a readily available N-Bromosuccinimide (NBS)/DMSO reagent system as a bromine source. High substrate scope, simple reaction conditions, application to natural products and glycals makes the process very attractive.

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Acknowledgement

The authors are highly thankful to director CSIR-IIIM (Indian Institute of Integrative Medicine) for the necessary facilities. SKY is highly obliged to DST-India for a research grant under the INSPIRE Faculty scheme. (IIIM-Publication number of the current study is IIIM/1828/2015).

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Authors and Affiliations

  1. Natural Product and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM), J & K, 190005, Sanatnagar, Srinagar, India

    Hafiz Ul Lah, Shabir Ahmad Mir, Gulzar Hussain, Rafiq Ahmad Wani & Syed Khalid Yousuf

  2. Academy of Scientific and Innovative Research (AcSIR), Uttar Pradesh-, 201 002, Ghaziabad, India

    Shabir Ahmad Mir & Syed Khalid Yousuf

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  1. Hafiz Ul Lah
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  2. Shabir Ahmad Mir
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  3. Gulzar Hussain
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  4. Rafiq Ahmad Wani
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  5. Syed Khalid Yousuf
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Corresponding author

Correspondence to Syed Khalid Yousuf.

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Ul Lah, H., Mir, S.A., Hussain, G. et al. Facile NBS/DMSO mediated dibromination of olefins including selected natural products and glycals. J Chem Sci 134, 18 (2022). https://doi.org/10.1007/s12039-021-02003-3

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  • DOI: https://doi.org/10.1007/s12039-021-02003-3

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