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Nickel(II), copper(II) and zinc(II) complexes with an N-pendent dimethyl derivative of an octamethyl macrocyclic ligand: synthesis, characterization and antimicrobial studies

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Abstract

Interaction of CH3I with L (3,10-C-meso-Me8[14]diene) in the ratio of 4:1 in ethanolic solution at room temperature yielded N-pendent dimethyl derivative [(L-2H)(–CH3)2] denoted by LZ. Interaction of nickel(II) acetate tetrahydrate with LZ and subsequent addition of NaClO4·6H2O produced square planar orange-yellow product, [NiLZ](ClO4)2. The reaction of copper(II) perchlorate hexahydrate with LZ afforded four coordinated square planar red [CuLZ](ClO4)2. However, on the reaction of zinc(II) nitrate hexahydrate with LZ furnished white six coordinated two distereoisomeric complexes [ZnLZα(NO3)2] and [ZnLZβ(NO3)2]. Axial addition reactions on four coordinated square planar [NiLZ](ClO4)2 with KX (X= SCN, NO3, Cl, Br or I) and NaNO2 resulted in six coordinated octahedral and square pyramidal axial addition products, such as [NiLZ(NCS)2], [NiLZ(NO3)(ClO4)], [NiLZCl(ClO4)], [NiLZBr2], [NiLZI2] and [NiLZ(NO2)](ClO4), respectively. However axial substitution reactions on [ZnLZα(NO3)2] with KY (Y= SCN, Cl or Br) and NaNO2 produced six coordinated octahedral axial substitution products [ZnLZα(NCS)2], [ZnLZαCl2], [ZnLZαBr2] and [ZnLZα(NO2)2]. Similarly, the axial substitution reactions on [ZnLZβ(NO3)2] with KI and NaClO4.6H2O resulted in six coordinated octahedral axial substitution products [ZnLZβI2] and [ZnLZβ(H2O)2](ClO4)2, respectively. The compounds have been characterized by analytical, spectroscopic, magnetochemical and conductivity data. The antimicrobial activities of the new ligand and its complexes have been tested against different micro pathogens.

Graphic abstract

Nickel(II), copper(II) and zinc(II) complexes with an N-pendent dimethyl derivative ligand LZ of an octamethyl tetraazmacrocyclic ligand were prepared. The compounds were characterized by different analytical and spectroscopic methods. Antibacterial and antifungal activities of these compounds against some bacteria and fungi were also investigated.

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Scheme 1
Str. 1
Str. 2
Str. 3
Str. 4
Str. 5
Str. 6
Str. 7

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Acknowledgement

We gratefully acknowledge the Ministry of Science and Technology, People’s Republic of Bangladesh, for awarding a Research Grant to Professor Dr. Tapashi Ghosh Roy and Professor Benu Kumar Dey, Department of Chemistry, University of Chittagong, Bangladesh.

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Authors and Affiliations

  1. Department of Chemistry, University of Chittagong, Chattogram, 4331, Bangladesh

    Suman Kanti Das Gupta, Saswata Rabi, Deponkor Ghosh, Farhana Yasmin, Benu Kumar Dey & Tapashi Ghosh Roy

  2. Department of Chemistry, Chittagong University of Engineering & Technology, Chattogram, 4349, Bangladesh

    Saswata Rabi

  3. Department of Microbiology, University of Chittagong, Chattogram, 4331, Bangladesh

    Sujan Dey

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  1. Suman Kanti Das Gupta
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Correspondence to Tapashi Ghosh Roy.

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Supplementary Information (SI)

Supplementary Information (SI)

The synthesis of N-pendent ligand LZ has been shown in Scheme S1 (Supplementary Information). IR spectra, mass spectra & fragmentation pattern, 1H-NMR and 13C-NMR spectra for the newly synthesized N-pendent ligand LZ have been included in, Figure-S1, Figure S2 & Table S1, Figure S3 and Figure S4, respectively. However, some representative IR spectra of metal complexes of LZ have been shown in Figure S5 to Figure S11. On the other hand 1H-NMR spectra for [NiLZ](ClO4)2, [ZnLZα(NO3)2], [ZnLZβ(NO3)2], [ZnLZα(NO2)2] and [ZnLZαBr2] have been added as Figure S12, Figure S13, Figure S14, Figure S15 and Figure S16, respectively. Some UV spectra of Ni(II) and Cu(II) complexes of N-pendent ligand LZ have been included in Figure S17. The nickel(II), copper(II) and zinc(II) complexes have been shown by Str. S1 to Str. S7. The results on antifungal and antibacterial activities of the new compounds have been included in Table S2 and Table S3 & Table S4, respectively. Supplementary Information is available at www.ias.ac.in/chemsci.

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Das Gupta, S.K., Rabi, S., Ghosh, D. et al. Nickel(II), copper(II) and zinc(II) complexes with an N-pendent dimethyl derivative of an octamethyl macrocyclic ligand: synthesis, characterization and antimicrobial studies. J Chem Sci 133, 7 (2021). https://doi.org/10.1007/s12039-020-01861-7

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  • DOI: https://doi.org/10.1007/s12039-020-01861-7

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