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BINOL accelerated Ru(II)-catalyzed regioselective C-H functionalization of arenes with disulfides and diselenides


A BINOL accelerated Ru-catalyzed ortho-selective C-H coupling of arenes tethered to 7-azaindoles is described with disulfides and diselenides under air. The thioether can be readily oxidized to sulfoxide and sulfone. The use of less expensive Ru-catalysis, substrate scope and scale-up are the important practical features.

Graphical Abstract

Ru-catalyzed ortho-selective C-H coupling of arenes tethered to 7-azaindoles with disulfides and diselenides has been accomplished under air. The use of less expensive Ru-catalysis, substrate scope and scale up are the important practical features.

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We thank the Science and Engineering Research Board (CRG-2018-000406) for the generous financial support. We also thank Central Instrumental Facility, Indian Institute of Technology Guwahati for NMR and DST-FIST for HRMS analyses.

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BAG, R., SARKAR, T., KUMAR, S.V. et al. BINOL accelerated Ru(II)-catalyzed regioselective C-H functionalization of arenes with disulfides and diselenides. J Chem Sci 131, 115 (2019).

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  • Arenes
  • C-H functionalization
  • regioselective
  • Ru-catalysis
  • chalcogen