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Synthesis, characterization and antimicrobial studies of cadmium(II) complexes with a tetraazamacrocycle (\(\hbox {L}_{\mathrm{B}}\)) and its cyanoethyl N-pendent derivative \((\hbox {L}_{\mathrm{BX}}\))

  • Md Shah Alam
  • Saswata Rabi
  • Md Masudur Rahman
  • Adrity Baidya
  • Manashi Debi
  • Tapashi Ghosh Roy
Regular Article

Abstract

An isomeric ligand, \(\hbox {L}_{\mathrm{B}}\) of 3,10-C-meso-\(\hbox {Me}_{8}\)[14]ane on alkylation reaction with excess acrylonitrile resulted in a stereoselective product trans-(3S,5S,10R,12R)-N1,N8-bis(2-cyanoethyl)-C-meso-derivative, \(\hbox {L}_{\mathrm{BX}}\). Reaction of \(\hbox {L}_{\mathrm{B}}\) with Cd(\(\hbox {ClO}_{4})_{2}\cdot 4\hbox {H}_{2}\hbox {O}\) in methanol gave the octahedral complex, [Cd(\(\hbox {L}_{\mathrm{B}})\)(\(\hbox {ClO}_{4})_{2}\)] whereas interaction of the ligand \(\hbox {L}_{\mathrm{BX}}\) with Cd(\(\hbox {NO}_{3})_{2}\cdot 4\hbox {H}_{2}\hbox {O}\) in methanol yielded a square pyramidal mononitratocadmium(II) nitrate complex, [Cd(\(\hbox {L}_{\mathrm{BX}})\)(\(\hbox {NO}_{3})\)](\(\hbox {NO}_{3})\) and an octahedral dinitratocadmium(II) complex, [Cd(\(\hbox {L}_{\mathrm{BX}})\)(\(\hbox {NO}_{3})_{2}\)]. The complexes, [Cd(\(\hbox {L}_{\mathrm{B}})\)(\(\hbox {ClO}_{4})_{2}\)] and [Cd(\(\hbox {L}_{\mathrm{BX}})\)(\(\hbox {NO}_{3})_{2}\)] underwent axial substitution reactions with KCNS and KBr to produce octahedral diisothiocyanatocadmium(II) complexes, [Cd(\(\hbox {L}_{\mathrm{B}})\)(NCS)\(_{2}\)] and [Cd(\(\hbox {L}_{\mathrm{BX}})\)(NCS)\(_{2}\)] and octahedral dibromidocadmium(II) complexes, [Cd(\(\hbox {L}_{\mathrm{B}})\hbox {(Br)}_{2}\)] and [Cd(\(\hbox {L}_{\mathrm{BX}})\hbox {(Br)}_{2}\)], respectively; whereas, [Cd(\(\hbox {L}_{\mathrm{BX}})\)(\(\hbox {NO}_{3})\)](\(\hbox {NO}_{3})\) underwent axial addition with KCl, simultaneous axial substitution and anion exchange with KCNS and simultaneous axial addition, substitution and anion exchange with \(\hbox {NaClO}_{4}\cdot 6\hbox {H}_{2}\hbox {O}\) to produce octahedral [Cd(\(\hbox {L}_{\mathrm{BX}})\)(\(\hbox {NO}_{3})\)Cl], square planar octahedral [Cd(\(\hbox {L}_{\mathrm{BX}})\)(\(\hbox {H}_{2}\hbox {O}\))\(_{2}\)](\(\hbox {ClO}_{4})_{2}\), respectively. The newly prepared compounds have been characterized by different analytical and spectroscopic methods. The antibacterial activities of the ligands, metal salts and complexes have been tested against two selected gram positive bacteria and two gram negative bacteria.

Graphical Abstract

Keywords

Macrocyclic ligands N-pendent derivative cadmium(II) complex spectroscopic studies antibacterial studies 

Notes

Acknowledgements

Authors would like to thank the University Grant Commission, Bangladesh for awarding a Research Grant to TGR.

Supplementary material

12039_2018_1438_MOESM1_ESM.pdf (438 kb)
Supplementary material 1 (pdf 438 KB)

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Copyright information

© Indian Academy of Sciences 2018

Authors and Affiliations

  • Md Shah Alam
    • 1
  • Saswata Rabi
    • 1
  • Md Masudur Rahman
    • 1
    • 2
  • Adrity Baidya
    • 1
  • Manashi Debi
    • 1
  • Tapashi Ghosh Roy
    • 1
  1. 1.Department of ChemistryUniversity of ChittagongChittagongBangladesh
  2. 2.Anti-corruption CommissionDhakaBangladesh

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