Abstract
Rhodanine derivatives are highly valuable heterocycles in drug discovery. Here, we developed aldol reaction of N-substituted rhodanines and aromatic aldehydes on water. The reaction was performed at room temperature affording the products in good to high yield. This synthetic protocol uses simple experimental procedures, catalyst-free, and avoids the use of highly toxic solvents.
Graphical Abstract
SYNOPSIS Aldol reaction of N-substituted rhodanines and aromatic aldehydes on water at room temperature has been described. This protocol is simple, catalyst-free, and avoids the use of highly toxic solvents.
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Acknowledgements
The authors acknowledge the support of this research by the Science and Engineering Research Board (SERB) (SB/FT/CS-170/2013), New Delhi, India. Authors are also thankful to Central Instruments Facility (CIF), IIT Guwahati, for spectral recording.
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Devi, N.S., Devi, N. Catalyst-free aldol reaction of N-substituted rhodanines on aqueous media. J Chem Sci 130, 18 (2018). https://doi.org/10.1007/s12039-018-1419-2
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DOI: https://doi.org/10.1007/s12039-018-1419-2