Abstract
Twelve novel sulfonamide hybrids were designed by molecular hybridization strategy. The target sulfonamide hybrids were obtained in the click reaction of azide derivatives and commerciallly available alkynes. All sulfonamide hybrids were evaluated for their antiproliferative activity against three selected cancer cell lines (MGC-803, EC-109 and PC-3). Most of the synthesized compounds exhibited moderate to good activity against all the cancer cell lines selected. Particularly, compound 8c showed the potent antiproliferative activity with an \(\hbox {IC}_{50}\) value of \(0.7\,\upmu \hbox {mol}\) against MGC-803 cancer cells. These sulfonamide hybrids might be promising lead compounds to develop antitumor agents in the clinical practice.
Graphical Abstract
SYNOPSIS. Twelve novel sulfonamide hybrids were designed by molecular hybridization strategy. These sulfonamide hybrids were synthesized by click reaction and evaluated for their antiproliferative activity. Among them, compound 8c showed potent antiproliferative activity with an \(\hbox {IC}_{50}\) value of \(0.7\,\upmu \hbox {mol}\) against MGC-803 cells.
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This work was supported by the National Natural Sciences Foundations of China (No. 81673322).
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Complete experimental procedures, spectral data and copies of 1H and 13C NMR of all novel compounds are given in Supplementary Information. Supplementary Information is available at www.ias.ac.in/chemsci. (pdf 827KB)
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Fu, DJ., Hou, YH., Zhang, SY. et al. Efficient click reaction towards novel sulfonamide hybrids by molecular hybridization strategy as antiproliferative agents. J Chem Sci 130, 6 (2018). https://doi.org/10.1007/s12039-017-1415-y
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DOI: https://doi.org/10.1007/s12039-017-1415-y