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Expeditious synthesis of coumarin-pyridone conjugates molecules and their anti-microbial evaluation

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Abstract

An expedient synthesis of coumarin-pyridone conjugate molecules 2a-o is reported via one-pot reaction between (E)-3-(3-arylacryloyl)-2H-chromen-2-ones 1a-o, ethyl 2-nitroacetate and ammonium acetate. The structures of synthesized compounds have been unambiguously confirmed by spectroscopic analyses (NMR, IR and MS). All the compounds were screened for their anti-microbial activities against three Gram-positive bacterial strains, two Gram-negative bacterial strains and four fungal organisms. Compounds 2d, 2i, 2k, 2o exhibited mild anti-bacterial activity and 2d, 2m were found to be moderately active against all the tested fungal organisms. Compound 2k showed good inhibitory potential against the tested yeasts organisms.

Graphical Abstract

Expedient synthesis of coumarin-pyridone conjugate molecules has been reported via one-pot, three-component reaction between (E)-3-(3-arylacryloyl)-2H-chromen-2-ones, ethyl 2-nitroacetate and ammonium acetate. Anti-microbial activity of these compounds was evaluated and the results indicated that some of the compounds exhibited mild anti-bacterial activity and good inhibitory potential against the tested fungal organisms.

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Acknowledgements

The authors are thankful to Department of Chemistry, University of Jammu for providing all necessary facilities, Department of Science and Technology, GOI, New Delhi for funding (Project No. SR/S1/OC-38/2010) and NMR facility under PURSE.

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Authors and Affiliations

  1. Department of Chemistry, University of Jammu, Jammu, Jammu and Kashmir, 180 006, India

    Rajni Khajuria, Sheena Mahajan & Kamal K Kapoor

  2. Department of Chemistry and Chemical Sciences, Central University of Jammu, Jammu, Jammu and Kashmir, India

    Rajni Khajuria

  3. Department of Chemistry, Government Degree College, Kathua, Jammu and Kashmir, 184 101, India

    Ambica

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  1. Rajni Khajuria
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  2. Sheena Mahajan
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  3. Ambica
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  4. Kamal K Kapoor
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Correspondence to Kamal K Kapoor.

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Khajuria, R., Mahajan, S., Ambica et al. Expeditious synthesis of coumarin-pyridone conjugates molecules and their anti-microbial evaluation. J Chem Sci 129, 1549–1557 (2017). https://doi.org/10.1007/s12039-017-1362-7

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  • DOI: https://doi.org/10.1007/s12039-017-1362-7

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